Barely Significant
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“did not reach statistical significance”

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In the literature

Lastly, in the smaller subset of patients with GS 3 + 4 = 7 carcinoma [Subset: GS = 3 + 4 = 7 (i.e., Grade Group 2), N = 341 patients], patients with cribriform glands >0.25 mm showed a trend toward lower RFS that was not seen in patients with cribriform glands of any size; however, this finding did not reach statistical significance (univariable p = 0.1).
In cELS of distended preparations incubated with both AZ10606120 and BzATP, the eATP decrease showed a trend to be lower than observed for distended preparations incubated with BzATP alone, but this difference did not reach statistical significance ( Figure 5 b).
Regarding the laterality effect of noise trauma, the PAC was significant only on the contralateral side ((contralateral noise-exposed (N) = 4157, control (C) = 3297, p = 0.02), (ipsilateral N = 4563, C = 3941, p = 0.34)); changes in contralateral MGB showed a trend, but did not reach statistical significance ((contralateral N = 4405, C = 3829, p = 0.07), (ipsilateral N = 4600, C = 3965, p = 0.14)); and the CA1 was significant bilaterally ((contralateral N = 6325, C = 5252, p = 0.03), (ipsilateral N = 6727, C = 5690, p = 0.04)).
When samples were divided according to the extent of SerpinB3 expression, tumors expressing a high level of SerpinB3 (>median value) showed a trend toward higher amounts of Wnt-1 and Wnt-7a compared to the corresponding figures observed in tumors with low SB3 level (<median value), although the difference did not reach statistical significance, probably due to the small sample size ( Supplementary Figure S1 ).
An overall trend toward an increase in BMI was observed at the long-term follow-up that however did not reach statistical significance due the small sample size, but in the majority of participants BMI changes were stable or improving over time [ 80 , 81 ].
The medium effect sizes indicate that although the study may have been underpowered due to a small sample and therefore did not reach statistical significance, there is an effect of medium importance in the cognitive areas of selective attention and language that may be significant in larger, more heterogeneous samples.
Conversely, the PD-risk factor T408M (also known as T369M, rs75548401) showed a trend toward a faster rate of cognitive decline that did not reach statistical significance, in keeping with a previous study. 43 The mild GD-causing variant N409S (also known as N370S, rs76763715) has shown inconsistent association with cognitive decline in PD.