“did not reach statistical significance”

Efficacy results did not reach statistical significance, but there was a positive trend [ 122 ].

While the group with low CLR (< 50%) showed a trend toward worse prognosis than those with high CLR (≥ 50%), this difference did not reach statistical significance (pRFS = 0.073, pOS = 0.075; Fig. 6 A-C).

The expression of M3R showed a decreasing trend, but it did not reach statistical significance, and the co-localization of ChAT and M3R showed no significant decrease (Fig. 4 A&B).

Microhardness showed an increasing trend with higher BA concentrations but did not reach statistical significance ( p > 0.05).

At month 1, the PPM 1 group showed a trend toward better visual acuity; however, this difference did not reach statistical significance (p = 0.054 ).

However, while AAE [−0.88, 95% CI [−2.05 to 0.29]], LSE [−0.04, 95% CI [−0.54 to 0.45]], and ME [−0.77, 95% CI [−1.66 to 0.11]] showed a trend toward improvement, their effects did not reach statistical significance.

In AEG patients with cT4 stage, an increasing trend of survival benefit was observed with a higher ELN count, although the association did not reach statistical significance (Fig. 5 F).

While RCME showed a slight trend toward higher lymph node yield, the difference did not reach statistical significance, indicating that both approaches achieve adequate oncological resection when performed by experienced teams.

Consistently, caspase-3 protein levels showed a trend toward elevation at both 1 week and 1 month, although the changes did not reach statistical significance ( Figure 4D ).

An analysis based on the Korean National Health and Nutrition Examination Survey (KNHANES) showed a negative trend between green tea intake and COPD risk among smokers, but the association did not reach statistical significance and detailed stratification by tea type or consumption pattern was lacking ( 26 ).

When the effect of orthodontic treatment duration on changes in bone loss was evaluated, an increasing trend in bone loss with longer treatment duration was noted, although this difference did not reach statistical significance ( p = 0.071).

SRS-22 scores showed a trend toward improvement but did not reach statistical significance.

Stratified analyses according to antiplatelet regimen In the SAPT subgroup, G4 showed a trend toward a higher 1-year risk of MACE compared with G1, although the association did not reach statistical significance (adjusted OR = 2.42, 95% CI 0.69–8.35, P = 0.154).

The M-HDAC3 −/− retinas showed a trend toward a decrease in Iba-1 count after crush; however, this did not reach statistical significance (Fig. 1C ).

The expression of Prdm16 showed an increasing trend but did not reach statistical significance.

Within the population with T2DM (N = 180), contrary to our initial hypothesis, metformin treatment showed a numerical trend towards shorter PFS, though this did not reach statistical significance (HR = 1.41, 95% CI [0.97–2.05], p = 0.069).

On that day, differences between groups did not reach statistical significance ( p > 0.05), although a numerical trend was observed in IL-6, CRP, the PaO 2 /FiO 2 ratio, WBC count, and temperature.

The urinary catheter removal time was significantly longer in the SLND group (β = + 1.24, 95% CI: 0.90–1.59, P < 0.001), while the time to first flatus showed a trend toward delay but did not reach statistical significance (β = + 0.35, 95% CI: − 0.01 to 0.70, P = 0.058).

No significant difference emerged in illness duration ( p = 0.383), while years of education showed a trend toward lower levels in the apathy group, though this did not reach statistical significance ( p = 0.057).

Input data modality showed a trend toward improved performance with multimodal approaches (94.1% sensitivity) versus OCT-only methods (84.5% sensitivity), though this difference did not reach statistical significance ( p -value = 0.224).

A higher LMR (≥ 3.0) showed a positive trend but did not reach statistical significance in adjusted models.

Importantly, even though the difference in OS did not reach statistical significance in the total population, a clear trend favouring the MDTc group was observed, and statistical significance was achieved in subgroup analyses suggesting a clinically relevant benefit that warrants further investigation.

Similarly, JJA sIgE levels showed a trend to be higher in subjects with LLR but did not reach statistical significance ( p = 0.14).

Age 3–17 years, tumor volume >8 cm3, and KPS 70–90 showed a trend toward association, but the differences did not reach statistical significance (HR = 2.01, p = 0.095; HR = 2.46, p = 0.087; HR = 0.50, p = 0.111) ( Figure 4 , Table 6 ).

IMP4 was significantly upregulated in GSE66407 , whereas it showed a decreasing trend in GSE179285 and GSE11223 , although the differences did not reach statistical significance ( Figure 4C ).