“highly significant”

The correlation between total viral genome copies and sub-genomic E gene copies was highly significant ( p = 3.81 × 10 −127 ), but a high level of variance was observed between live viral titres measured by focus forming assay and both total and sub-genomic RNA titres ( Figure 4 a).

Compared to size-matched random genomic regions, K122Q-bound enhancers showed highly significant enrichment of the canonical CRE motif (Fold Enrichment=13.7, P =1.0 × 10 -125 ), with 42.5% of enhancers containing the motif versus 3.1% of background regions ( Supplementary Fig. 2 ).

[ 19 ], 244 were significantly positively correlated to YAP1 expression in the GSE45547 expression dataset, demonstrating a highly significant enrichment ( Figure 6 B; Hypergeometric test, p = 1.961398 × 10 −122 ).

Though no single pPGS reached the same degree of significance as the gwPGS, interactions were highly significant for multiple pathways, including glycerolipid metabolism ( p = 2.0 × 10 −122 ) and focal adhesion ( p = 2.9 × 10 −60 ) ( Figure 2 A).

This enrichment was highly significant ( P = 2.35 × 10 −121 ) with an odds ratio of 12.90, indicating that outlier SVs were nearly 13 times more likely to occur within regions of elevated genetic differentiation based on SNPs.

1c and 1d ) is highly significant ( χ 2 test-statistic = 548.68; d.f. = 2; N = 1,913; P = 7.2 × 10 −120 ).

Statistical analysis showed that there was a strong and highly significant negative correlation between the rate of change in expression and chimeric frequency (Pearson: r = −0.556, p = 4.69 × 10 −119 ; Spearman: r = −0.601, p = 7.34 × 10 −144 ).

The CytoTRACE score showed a weak but highly significant negative correlation with latent time (Spearman ρ = −0.25, p = 1.9 × 10 −118 ), indicating that, although capturing distinct facets of the transcriptome, the two orthogonal approaches suggested on a common developmental trajectory from mesophyll precursors toward terminally differentiated guard cells ( Tables S1 and S2 ). 3.2.

Although we cannot rule out the possibility that widespread shallow oscillations persisted, a comparison between the same genes in Ctrl and SCNx groups showed a dramatic and highly significant (Wilcoxon signed-rank test, P = 8 × 10 − 114 ) decrease in amplitude after SCN lesion (Fig. 1 L, left).

What the reviewer fails to mention is that because 32% of genes do change orientation and given a sample size that will make expectations highly significant, the null hypothesis of no change will be rejected by a more significant P value (P = 10 -113 ) by Fisher test, therefore rejecting the WGD model .

The coefficient of linear correlation between the input and output signals was r = 0.9421, and it was highly significant ( p = 1.46 × 10 –111 ).

Meta-analyses of cis -eQTLs for brain-related traits show at least one variant in the ANKDD1B gene to be highly significant in the cortex ( P = 3.18×10 -110 ; Table F in S1 Table ) and nominally significant in the hippocampus ( P =.003; Table G in S1 Table ) [ 26 ].

As anticipated, lipid ratios capturing PUFA synthesis, namely PE(P-16:0_18:2)/PE(P-16:0_20:4), PE(P-18:0_18:2)/PE(P-18:0_20:4), PE(P-16:0_18:3)/PE(P-16:0_20:5) and PE(P-18:0_18:3)/PE(P-18:0_20:5), exhibited highly significant associations with FADS1/FADS2/FADS3 loci [575 SNPs; top hit: rs174564 for the PE(P-18:0/18:2)/PE(P-18:0/20:4); imputation r 2 = 0.999; beta = 0.49; p-value = 8.07 × 10 −107 ; p-gain = 2.60 × 10 +83 ].

Bioinformatics analysis of training cohorts identified a 61-gene signature that was highly significantly associated with RFS (HR = 37.08, P = 2.68*10 −106 , sensitivity = 89.29%, specificity = 89.61%, and AUC = 0.937).

Using these analytic approaches, we found that each of the eight groups of sex-specific genes listed in SM- Table 3 a-3b are jointly and significantly associated with longevity in one sex ( P = 8.7 × 10 −165 ∼1.5 × 10 −37 ), but not jointly significant in the other sex ( P > 0.05), while PRS-sex interaction effects are highly significant ( P = 5.2 × 10 −106 ∼4.4 × 10 −15 ) (SM- Table 5 ).

Next, based on the z score in the latent factor mixed models (LFMMs), we detected 155 CNVs with |z| scores ≥ 10 ( Supplementary Table S11 ) that were highly significant (3.63 × 10 −6 ≥ p values ≥ 1.34 × 10 −103 ), associated with environmental parameters in 47 old sheep populations.

Among these, MTND2 had highly significant associations across HDL cholesterol, Apolipoprotein A1, LDL and Triglycerides (lowest P = 3.2 × 10 –103 ).

Other highly significant proteins for AD included GFAP ( β = 0.676; FDR-adjusted p = 5.02 × 10 −102 ), p-tau231 ( β = 0.700; FDR-adjusted p = 4.42 × 10 −94 ), NEFL ( β = 0.417; FDR-adjusted p = 1.52 × 10 −48 ) and p-tau181 ( β = 0.483; FDR-adjusted p = 9.25 × 10 −46 ; Supplementary Table 1 ).

All these variables have a statistically highly significant correlation (P~10 −100 ).

Likelihood ratio tests indicated a highly significant genetic effect (LRT = 197.9, df = 1, P < 10 -100 ), suggesting that approximately 70% of the phenotypic variation is attributable to genetic factors.

The likelihood ratio test further indicated that the genetic effect was highly significant (LRT = 1,655.76, df = 1, P < 10 −100 ) ( Kang et al., 2008 ; Yang et al., 2011 ; Visscher et al., 2008 ).

Similarly, when surveying combined protein expression and SV data across 328 cell lines 38 , 54 , 55 , we observed a highly significant overlap ( p < 1E−100 chi-square test) of events involving CRISPR knockout effect in genes with events involving SV-associated protein over-expression (Fig. 8b ), involving 2682 genes, 178 with combined breakpoint and protein over-expression involving at least 5% of cell lines examined (Supplementary Dataset 10 ).

A more detailed analysis reveals that a clear and highly significant ( p < 10 -100 , Wilcoxon rank sum test) difference is seen between the mean of the CP M sc ( M ̄ s c = 0.19 ± 0.30) and the mean of the negative sequence M sc ( M ̄ s c = 0.02 ± 0.09).

This comparison yielded a highly significant overlap ( P < 1e−100) in 2419 of 3802 DEGs, validating our adopted strategy ( supplemental Figure 1 D).

The SNP-based heritability estimated on the observed scale was 0.78% (SE = 0.04%), which was highly significant (Z = 21.09, P-value = 9.41 × 10−99), further supporting a polygenic basis for ovarian cancer.