“highly significant”

There was a highly significant trend in increased risk associated with BMI categories of ≥25 to <30 and ≥30 ( P = 1.4 × 10 −39 ).

A highly significant reduction ( p = 2.3 × 10 –39 ) in the number of Candida colonies was observed in the treatment arm when comparing pre- and post-study results.

The total GRS based on 80 known index SNPs showed a highly significant association with T2D (OR 1.07 [95% CI 1.06–1.08] per risk allele; P = 2.31 × 10 −39 ) ( Table 2 ).

There was a highly significant correlation between relative amounts estimated based on OTU counts and on raw reads data (Pearson c = 0.9947; p = 3∙10 −39 ; Supplementary Figure 3 ).

falciparum ’s large proteins displayed unique and parasite-specific annotations, with a highly significant presence of host cell binding functions ( P = 3.21e−39) compared to the rest of the proteome.

The results of the test were highly significant ( P = 3.41 × 10 −39 ; Fig. 4c, d ), proving that there is a strong relationship between the data-driven GGM and the known IgG glycosylation pathway.

S4b ), we found a highly significant peak on chromosome 17 (Fig. 6a , Supplementary Data 5 and 6 ) where the lead variant was an intergenic SNP upstream of the BMP2 gene (chr17:15643342:C>T, P = 3.45 × 10 − 39 ).

IPA upstream analysis estimated module-specific upstream regulators, including transcription factors (Table S2 ), and suggested that the transcription factor MITF was activated in co-module #12, which was highly significant among co-modules (IPA overlap p-value = 6.91E-39, Fig.

Remarkably, 35 insertions are located at common insertion sites (CISs), a highly significant result (Fisher's exact test p = 7.4×10 −39 ) ( Table 1 ).

These results were corroborated by the analysis of functional pathways using the ConsensusPathDB 25 (Methods); gene sets showed highly significant overlaps ( P <7.66 × 10 −39 –2.38 × 10 −05 ) with pathways involving OR and GPCR-related signalling and signal transduction, (extra-cellular matrix related) processes of inter-cellular communication, immunoregulatory processes and membrane-linked drug transport.

4c ) show that the TE and ICM nuclei in blastocyst embryos have highly significant differences in the mean nuclear dry mass density ( p -value = 8.11e−39), while the differences for cleavage state embryos are nonsignificant ( p -value = 0.0105).

To further investigate the significance of these directional findings we estimated the differences in the slopes using z-scores and demonstrated that for 31 of the 35 genes the differences were highly significant (Bonferroni corrected p<1×10 −38 ) ( Supplementary Table 4 ), thus strongly suggesting these were not chance observations.

Using a logistic regression model, we found that several factors had a highly significant influence on whether a proximal eQTL was detected as an aiQTL; namely, the distance of the eQTL from the TSS (P = 1 × 10 − 38 ), the number of samples with more than one allele-specifically mapped read (P = 1 × 10 − 88 ), the log P value of the eQTL (P = 3 × 10 − 174 ), the minor allele frequency of the eQTL (P = 2 × 10 − 44 ) and the median number of allele-specifically mapped reads (among samples with more than one allele-specifically mapped read; P = 0.008).

Interestingly, in a joint model where both rs970740 and rs6025 were used as covariates for predicting cg16548605 variability, the effect of rs970740 was highly significant (p = 1.05×10 −38 ) but that of rs6025 was not (p = 0.90).

Similarly, Table 4 reveals a highly significant effect of elevation height on PV efficiency (F = 134.21, p = 1.31 × 10– 38 .

GO enrichments for the lightgreen module are highly significant for “secretory granule” (p=2.14E-38), “secretory vesicle” (p=1.96E-36), and different specific neutrophils-associated terms such as “neutrophil activation involved in immune response” (p=1.04E-35), “neutrophil degranulation” (p=1.04E-35), “neutrophil activation” (p=2.00E-35), and “neutrophil mediated immunity” (p=2.64E-35).

We measured the relative abundance of the total ether-linked lipids and observed a highly significant elevation ( p -value = 2.94E-38) of total ether-linked lipids at 48 h post virus infection ( Figure 5C ).

While the small (∼5 nm) difference between the early and late S-phase distributions is statistically highly significant (Kolmogorov–Smirnov test, P = 3e-38), it is unlikely that, given the ∼30-nm standard deviation of the individual distributions, this difference has biological significance.

The ISR total change included 7259 patients and showed a highly significant trend in an F statistic versus constant model with F = 169, p = 3.13 e − 38.

Module detection followed by a meta-analysis on chronological age identified fifteen consistently coexpressed PPI modules associated with chronological age, including a highly significant module ( P = 3.5 × 10 −38 ) enriched for ‘ T-cell activation ’ marking age-associated shifts in lymphocyte blood cell counts ( R 2 = 0.603; P = 1.9 × 10 −10 ).

The most highly significant variant at 5q33.1 (rs17728338) shows opposing effects on AD and psoriasis (MNM p = 3.96 × 10 −38 ; Table S5 ) and lies 2 kb upstream of ANXA6 (MIM 114070 ) and 8 kb downstream of TNIP1 (MIM 607714 ).

In addition, a highly significant number of these genes have a SMARCB1 ChIP-seq peak ( p -value = 5.43e −38 , Fig. 5b ), confirming that genes regulated by SWINGN share their regulation with SWI/SNF.

A highly significant S-PrediXcan signal ( p = 6.10e–38) was also obtained for this WDR19 intron cluster in testis, however the evidence for colocalization with the GWAS peak was low (PP.H4.abf = 0.39).

The QPHSg.wsu-2D locus was highly significant in this GWAS (7.64 < –log 10 ( p ) < 37.13), and had strong effects (0.02 to 0.72).

We observed a highly significant correlation ( R 2 = 0.5086, p = 8.5e−38; data not shown).