“highly significant”

When we test the association of each PC with ER status, PC1 scores have a highly significant association with ER status ( p < 10 −46 , Wilcoxon rank-sum test), whereas PC2 and PC3 are less associated (Fig. 2 b).

With a global average of 52.7% ± 0.12% history-congruent trials, we found a small but highly significant perceptual bias towards preceding experiences ( β = 16.18 ± 1.07, T(1.09×10 3 ) = 15.07, p = 10 −46 ; Fig 2A ) that was largely consistent across studies ( S1B Fig ) and more pronounced in participants who were less sensitive to external sensory information ( S1C Fig ).

The libraries M19 and M25 have 0,985 as correlation coefficient and have a highly significant regression (P = 2,31 × 10 -46 , after Bonferroni correction P = 7,49 × 10 -43 ).

Circulating T cell fraction remained highly significant after adjusting for clinical factors in the pan-cancer cohort (Fig. 5b (HR = 0.76, P = 2.6 × 10 −46 ) and Extended Data Fig. 9a ) and within five individual cancer types after multiple hypothesis correction—head and neck squamous cell carcinoma (HR = 0.70, adjusted P = 4.68 × 10 −2 ), pancreatic adenocarcinoma (HR = 0.74, adjusted P = 4.81 × 10 −2 ), colon adenocarcinoma (HR = 0.85, adjusted P = 1.12 × 10 − 2 ), lung adenocarcinoma (HR = 0.80, adjusted P = 5.4 × 10 −3 ) and sarcoma (HR = 0.68, adjusted P = 1.57 × 10 −4 ).

A highly significant association was observed between BMI and triglyceride levels (Beta = 0.26, p = 3.06E-46), and a positive correlation trend was also seen between BMI and UA.

According to GeneAtlas, FYCO1 variant rs33910087 is a highly significant modifier of monocyte percentage ( p = 3.85 × 10 −46 ), and based on GTEx v8, this variant is also an eQTL for several protein-coding genes previously associated with COVID-19 ( CXCR6 , FYCO1 , SLC6A20 , CCR1 , LZTFL1 ).

These represent 41% and 33% of upregulated phosphoproteins in OCMI91s and OVCAR8 cells, respectively - a highly significant overlap by hypergeometric test (enrichment 3.0-fold; p = 4x10 -46 ).

Paf1 exhibited highly significant enrichment around the TAD boundaries (p = 4.8E-46) but not replication origins (Figs 7C and S6B ).

The ANN achieved an F-statistic value of 432.7, indicating a highly significant model fit with a practically negligible probability of F-statistic ( p < 6.06 × 10 −46 ).

The two conditions shared a highly significant ( P < 10 −45 , hypergeometric test) overlap of 741 genes ( Fig. 5 B ).

5 E) demonstrates highly significant segregation of GBMs and LGGs ( P <10 –45 , odds ratio=28, Fisher exact test) supporting that YAP activation is a hallmark of malignant brain cancer and suggesting that this eight-gene signature might provide sufficient information to distinguish high-grade from low-grade gliomas.

In agreement with this, when restricting the analyses to Trans- CDS, ABO is still highly significant ( p = 1.18 × 10 −45 ), in contrast to OBP2B where the p -value drops dramatically ( p = 2.49 × 10 −13 ).

Of note, a highly significant association (− log 10 P = 44.79) for ‘seed: colouration with phenol’ on chromosome 2A was just 0.37 Mb from the Ppo-A1 gene known to control discolouration in wheat food products.

Three transcription factors were highly significant; MYCN (p-value = 1.71E-45), MYC (p-value = 1.11E-11) and NFE2L2 (p-value = 5.97E-17) during this analysis.

In contrast, within-tumor tests of total K14 were highly significant ( p = 2 × 10 −45 , Fig 9B ).

Analysis using the GEPIA database revealed a highly significant correlation ( p = 2e -45 , R = 0.82) between these markers, providing new insights into the molecular mechanisms underlying PAAD progression and identifying new targets for diagnostic and therapeutic strategies.

briggsae strains revealed a highly significant effect of both strain ( P = 2.2×10 −45 ) and generation ( P = 5.9×10 −9 ) – see Table 2 .

In contrast, polygenic risk scores (PRS) aggregating effects of minor alleles of independent SNPs that were adversely or beneficially associated with disability showed highly significant associations in meta-analysis, p=3.13×10-45 and p=5.60×10-23, respectively, and were replicated in each study.

In contrast, polygenic risk scores (PRS) aggregating effects of minor alleles of independent SNPs that were adversely or beneficially associated with disability showed highly significant associations in meta-analysis, p=3.13×10-45 and p=5.60×10-23, respectively, and were replicated in each study.

The paired change was highly significant (McNemar’s χ 2 (1) = 198.89, p < 3.65 × 10 −45 ) ( Figure 4 ).

MMP14 exhibited a marked increase in expression in tumor tissues, with a highly significant difference between normal and cancer groups ( p = 4.9 × 10 −45 ).

Among 11 prototypical sarcomere genes, 10 displayed highly significant isoform shifts (p = 5.23 × 10 −45 –2.89 × 10 −200 ).

When looking at the genes that overlapped between these two comparisons, we found 99 overlapping up-regulated genes and 84 overlapping down-regulated genes, which represented a highly significant overlap between comparisons ( Fig. 4 A ; P = 6.32 × 10 −45 ).

A chi‐square test confirmed that this enrichment was highly significant ( p = 1.1357 × 10 −44 ), underscoring the prominent role of DNA transposons in gene regulation.

That the three sets of enriched positions contained an overlap of 106 sites was highly significant with a hypergeometric P < 1.47 × 10 −44 .