Barely Significant
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marginal significance

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p=0.07

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

marginal significancep = 0.061.2× alphagold
When adjusted for the same covariates, CD was not associated with neurologic morbidities in the moderate to late (aHR 1.11, 95% CI 0.94–1.32) and very preterm (aHR 1.34, 95% CI 0.74–2.45) groups, while in extremely preterm, CD was found significant (aHR 4.06, 95% CI 1.18–13.9). Infectious morbidities The assessment of the first episode of infection in offspring, including disease subgroups (Table S2 ), showed a higher prevalence of infectious events in the CD group, with 1608 (69%) versus 1051 (62%) in the VD group (OR 1.39, 95%CI 1.22–1.59), although the marginal significance, this was also supported by the Kaplan–Meier survival curve (Fig. 2 c, Log-rank p = 0.06).
marginal significancep = 0.061.2× alphagold
Conversely, TLR4 expression decreased dose-dependently with significantly more TLR4 expression seen in 1 ng/ml (p = 0.004) and with marginal significance at 5 ng/ml HMGB1-stimulation (p = 0.06) ( Figure 2E ). 3.5 HMGB1 induces Pp38 MAPK pathway To better understand the MAPK pathway activation by HMGB1, a semi quantitative assessment of phosphorylated (P) MAPK proteins was carried out.
marginal significancep = 0.0601.2× alphagold
Using Image J software to analyze the fluorescence quantification of 4-HNE immunofluorescence staining, marginal significance was observed for the exercise main effect on the relative fluorescence intensity of 4-HNE [ F (1, 8) = 4.771, p = 0.060, η 2 = 0.374, Figure 5M ] and for the interaction effect on the area of 4-HNE positive staining [ F (1, 8) = 4.746, p = 0.061, η 2 = 0.372, Figure 5N ].
marginal significancep = 0.06091.2× alphagold
While not significantly prognostic, histologic grades still showed a certain level of prognostic value in our study, as evidenced by the marginal significance in univariable analysis in D1 and D2 (D1: p = 0.0609 for high versus intermediate and low grade; D2: p = 0.0599 for high and intermediate versus low grade) and survival analysis for D 1+2+3 in Supplementary Fig. 5 .