“modestly significant”

The authors have also found the change in investor sentiment modestly significant (at 10% level), which is not significant in our results either.

After correction for multiple comparisons, we found a modestly significant association between a haplotype in the GABA-β1 receptor subunit with motor limitation scores.

The detection of a single associated pathway, despite an excess of modestly significant p-values, also suggests that (as in GWAS) larger samples are needed.

Finally, although phloretin showed a protective trend, its effect on functional recovery, such as grip strength, did not reach statistical significance in the LLC model and was only modestly significant in the C26 model.

Additionally, both the soil C pool and plant C accumulation also emerged as modestly significant predictors of yield performance ( Figure 7 ). 3.

The group consisting of swd1 Δ , swd2 Δ , swd3 Δ, set1F H3K4me− , and H3K4R mutants included smaller subsets of differentially expressed probes ( Figure 1C , upper panel), with modestly significant GO enrichment for upregulated transcripts related to stress response and carbohydrate metabolism ( Figure 1—source data 1A ).

Only modestly significant differences for just three of the implemented deleteriousness metrics (M-CAP, fathmm-mkl and MutTaster) were observed comparing all IBD against controls in this relatively small sample.

Similarly, for the PA14 Δ pelA + pelA complemented strain, a modestly significant change, in this case, a decrease, in CFU/mL was observed (Fig. 2d ).

While the remaining pairwise tests all failed to demonstrate a significant slope or intercept when not constrained through the origin, each did exhibit at least a modestly significant positive slope when constrained through the origin, suggesting some degree of pleiotropy or causality between each trait ( Fig. 4 ).

In a large population-based cohort study of postmenopausal women with a history of oral bisphosphonate exposure, the use of Dmab was associated with a modestly significant 13% decreased risk of subsequent breast cancer, suggesting a potential protective effect of Dmab use on breast cancer risk in older women previously treated with bisphosphonates [ 34 ].

For instance, a negative correlation of −0.1 may be only modestly significant in one cancer type but highly significant in another cancer type due to different sample sizes, which may to some extent even mislead one to think that the identified interactions were cancer-specific when it in fact ubiquitously occurs among many other cancers.

The two remaining conditions, ethanol and salt, had modestly significant QTL peaks at this locus, but shared a stronger peak on chromosome IV ( Figure 2 and Table S9 ).

We also included 4 additional SNPs (shown in italics in Table 2 ) that although did not reach genome-wide level of significance for HDL-C [7] , [8] , they were either highly significant for HDL-C or modestly significant for HDL-C but genome-wide significant for at least one of the three other lipid traits (TC, LDL-C or TG).

Indeed, since this study included only a small number of samples, with only modestly significant sites, the validation of such significant sites is important.

The modestly significant positive correlation between the change in real-time right insula-dmFC functional connectivity and improvement in motor function scores was observed only in the MI-NF group suggesting training-specific effects.

Thus, having a “neutral” attitude and assuming prior odds for H0 = 1:1, p -values of 0.001 (as reported in a study on tension headache [ 12 ]) would give a modestly significant (0.043) posterior probability.

A modestly significant 58% reduction vs. placebo in sputum elastase was observed with acebilustat treatment.

Limited research has examined the impact of BMI on peripheral enthesis, revealing a modestly significant connection between the Madrid Sonographic Enthesitis Index for ultrasound-assessed enthesitis and BMI [ 15 ].

Correlation between chroAge and PhenoAge was strong for TW (r=0.93) but only modestly significant for TM (r=0.57).

3 b, d ): top AFR hits became only modestly significant in Europeans, whereas top European hits were almost uniformly non-significant in Africans, with most p-values falling orders of magnitude above genome-wide thresholds despite preserved effect directions.

The compositional analysis of PMA-treated and untreated samples revealed modestly significant differences based on the PMA-index metric only for a few, low abundant taxa, only at certain body sites (Fig.

Upon stratification by study center, six of the 32 candidate TLR -associated SNPs were identified as modestly significant determinants of PCA risk after adjusting for age, as shown in Table 3 .

Interestingly, we observed that, in patients with late-stage HCC, the E2F7 gene showed significant differential expression between class I and class II cell populations, while a modestly significant difference of expression was found in stage II patients.

In contrast, a smaller Canadian study drew the opposite conclusion after appropriately adjusting for smoking status 27 and a meta‐analysis of four pathological studies revealed a modestly significant odds ratio that approached a value of 1. 6 The present data on recurrence argue against more severe or frequent strokes underlying this interaction between PD and stroke since it does not fit the observation of decade‐long ongoing synergy.

Both TSPO and SGK1 show steroid/PPAR–lipid/xenobiotic pathway binding tendencies that are clearly consistent and relevant to HP, but statistically, they appear to be modestly significant and more dependent on the biological context.