“narrowly missed statistical significance”

GT + TT) the risk narrowly missed statistical significance.

Although this effect narrowly missed statistical significance and must not be overstated, its direction is coherent with the architectural findings.

Most recently, the PARAGON‐HF trial, which compared sacubitril/valsartan to valsartan, narrowly missed statistical significance for the primary endpoint of total heart failure hospitalizations and cardiovascular death. 17 However, the data from PARAGON‐HF suggested that patients with LVEF at or below the pre‐specified median of 57% had a greater treatment benefit than those with higher LVEF, and this finding was confirmed when LVEF was assessed continuously.

Although the dominance × group interaction narrowly missed statistical significance, the medium effect size indicates a trend toward sport-specific modulation that warrants verification in larger cohorts.

These results indicate a potential trend toward greater improvements in the intervention group, although the interaction effect at EVA 5 narrowly missed statistical significance. 2.

Consequently, the total hospital costs were lower in the hybrid group, though the difference narrowly missed statistical significance (EUR 18,170.6 ± 737.1 vs.

All other subscales showed moderate correlations but narrowly missed statistical significance.

In the event, Neo-ALLTO showed an absolute improvement of 20 % in pCR rates, and ALLTO narrowly missed statistical significance with an HR of 0.84 (97.5 %, CI 0.70–1.02), which was predicted to be HR 0.83 (Fig. 4 ), potentially owing to too few patients in the relevant comparisons.

Notably a third trial, KEYNOTE-604, assessing the addition of pembrolizumab to first line carboplatin and etoposide, demonstrated a similar improvement in PFS to the studies of the PD-L1 inhibitors above, but narrowly missed statistical significance for an OS benefit; detailed results of this study have not yet been presented or published.

Although the Log-Rank test was significant for both endpoints, the p-value from the Cox regression narrowly missed statistical significance in both analyses.

Although the latter result narrowly missed statistical significance, the consistency between analyses suggests that CTP was associated with a higher detection rate of peri‐ictal abnormalities compared to MRI.

The trial narrowly missed statistical significance for its primary endpoint of a composite of total hospitalizations for HF and death from cardiovascular causes ( Solomon et al., 2019 ).

As a sensitivity analysis, we also fit a model containing all candidate predictors without prior selection (Supplementary Table S2); effect estimates were consistent with the main analysis in direction and magnitude, although frailty narrowly missed statistical significance in the full model (aOR: 0.72, 95% CI: 0.51 to 1.02).

Yet, the larger phase III KEYNOTE-240 trial narrowly missed statistical significance for overall and progression-free survival, even though numerical improvements were observed [ 84 ].

Although β-alanine narrowly missed statistical significance after multiple testing correction ( q = 0.056; Table S8 ), the trend was reproducible across all experiments ( Fig.

Although the primary endpoint narrowly missed statistical significance immediately after treatment, iCBIT showed a clear trend toward greater tic reduction measured with YGTSS-TTS compared with the placebo condition.

93 In a subsample of the National Health and Nutrition Examination Survey III, the prevalence of sarcopenic obesity was 42.9% in men and 18.1% in women, but only women had an increased risk of all-cause mortality with sarcopenic obesity (although this narrowly missed statistical significance if mobility limitations were added to the regression analysis). 94 Possibly associated with the risk of morbidity (but having an inconsistent effect on mortality), sarcopenic obesity has been associated with increased risk of adverse cardiovascular events.

Although the intraoperative complication rate was numerically lower in the RC group, the difference narrowly missed statistical significance.

Although the modulation of the ALS effect by the order of transition narrowly missed statistical significance, asymmetric list shifting was observed only for the MC-MI first-order, not for the MI-MC first-order.

However, in the Phase 3 LEAP-002 trial ( NCT03713593 ), the combination narrowly missed statistical significance compared to lenvatinib alone, likely due to unexpectedly strong outcomes in the control arm [ 59 ].

While this narrowly missed statistical significance, it is a striking observation that should be further explored in a larger cohort.

At week 16 of treatment, there was a trend for insulin resistance to improve in the Jiangtang Xiaozhi group compared to the placebo group, but the change narrowly missed statistical significance.

The primary analysis showed a mortality of 35% in the ECMO group versus 46% in the conventional management group ( P = 0.09), which narrowly missed statistical significance.

More recently, the CREDENCE study, in which the majority of patients had reduced renal function, showed that canagliflozin narrowly missed statistical significance for reducing CV death even in this at-risk group of patients [ 23 ].

However, the primary composite endpoint narrowly missed statistical significance [ 97 ].