“narrowly missed statistical significance”

While none of the 1463 Reactome pathways were significantly enriched for DC differential expression (corrected p -value at 0.05), two pathways were significantly enriched for AC (Platelet sensitization by LDL and Response to metal ions), three for TI (Cytoprotection by HMOX1, Haem signalling and Response to metal ions), and one was significant for R (Aflatoxin activation and detoxification), and four narrowly missed statistical significance, including two interferon signalling pathways—gamma and alpha/beta (corrected p -value at 0.059, Supplementary Fig. 7B ).

Heterogeneity was very high (I 2 = 96.0%, P < 0.001), and the result narrowly missed statistical significance.

During the 24-week trial, only the 30 U group separated from the control group, but the numerically superior improvement narrowly missed statistical significance at the primary endpoint [ 21 ].

Potential contributors to this narrowly missed statistical significance on the primary outcome are a higher placebo response than in the phase 2 study and a generally more refractory patient population (median [range] number of prior or baseline ASMs was 8 [3–27]).

The S 2 TOP-BLEED score at baseline was associated with more severe bleeding in both univariate and multivariate analyses, whilst the S 2 TOP-BLEED score on treatment was associated with more severe bleeding in univariate but narrowly missed statistical significance in the multivariate model.

Regarding demographic factors, although the p ‐value for gender ( p = 0.053) narrowly missed statistical significance in our multivariate analysis, we retained it due to its strong clinical relevance.

In contrast, path analyses demonstrated that exposure to thin-ideal images at Time 1 positively affected the internalization of the thin ideal at Time 2 in the model including positive body talk, although this effect narrowly missed statistical significance in the models including negative fat talk and negative muscle talk.

The common effect model narrowly missed statistical significance with a p -value of 0.056.

control comparisons), the t -tests comparing the RTs of OL, TE , and RB position groups to those of controls narrowly missed statistical significance, whereas the RT comparisons between each of the five remaining position groups ( WR, QB, DL, LB, DB ) and controls were statistically significant.

Apabetalone, a bromodomain (BRDU) inhibitor, has recently been tested in a large phase III clinical trial and the results only narrowly missed statistical significance [ 54 ] (updated findings were disclosed in AHA-2019).

Furthermore, our data show lower pyramidal symptom prevalence among the male subjects with the rs1801157 TT genotype when compared with the other genotypes, although the results narrowly missed statistical significance, possibly due to the rarity of this genotype in our sample.

The 50-69-year age group also demonstrated a higher hazard of death, although the association narrowly missed statistical significance.

This patient‐level sex subanalysis further highlights a stronger association between RPs high and CVD in females (229% increased risk) compared to males (119% increased risk), although the latter narrowly missed statistical significance.

Nonetheless, absolute islet mass also rose 30% in both treated groups although the increase narrowly missed statistical significance in shams due in part to variability within the group (4 animals did not have values greater than the mean of controls while 3 were markedly increased).

Although the overall regression model narrowly missed statistical significance, internalized stigma emerged as a significant negative predictor of weekly PA engagement, with confidence intervals sufficiently distant from unity to suggest a stable effect.

Similar trends were observed in interaction analyses, where the interaction term between MRA use and guideline period in predicting 6‐month mortality narrowly missed statistical significance ( P for interaction = 0.052).

For example, the change in NT-proBNP narrowly missed statistical significance and was in the direction of benefit, consistent with other trials of SGLT2i in nondialysis populations.

Female sex was significantly associated with worse survival in the univariate analysis but narrowly missed statistical significance in the multivariate analysis.

In the study from the Pediatrix® database, mortality was almost a third lower in infants with PH and pulmonary hypoplasia exposed to iNO but this difference narrowly missed statistical significance [ 27 ].

Efficacy of iCBIT Compared to f2f CBIT Since our primary endpoint narrowly missed statistical significance, the key secondary analysis was tested in an exploratory instead of a confirmatory way.

This exploratory pilot study also reported a decrease in baseline/interictal saliva CGRP levels for participants receiving BoNT, although this difference was only observed after the third month and narrowly missed statistical significance when compared to placebo-control group.

CAR showed a modest advantage (SMD = 0.20, 95% CI: 0.00–0.40), which narrowly missed statistical significance (Fig. 7 ).

Statistically significant benefits were observed at 2 and 3 weeks, and the largest effect size was observed at 4 weeks, although the result narrowly missed statistical significance, possibly due to the limited sample size and high heterogeneity rather than a lack of therapeutic benefit.

Taken together, while these results indicate a direction of improvement, the fact that the primary pooled effect narrowly missed statistical significance, combined with high heterogeneity, suggests that the evidence for a general beneficial effect on PTSD symptoms remains inconclusive in the overall analysis.

44 , 45 This maybe the reason behind the fact that improvement in pCR by 20% in the case of the Neo-ALLTO trial, narrowly missed statistical significance in the ALLTO trial (HR 0.84, 97.5 % CI 0.70-1.02). 46 , 47 Selected ongoing Cb NACT studies in TNBC There are several studies evaluating various schedules and combinations of Cb in the NACT of TNBC ( Table 2 ).