“near-significant”

Constant peaks enriched for constant genes with a higher but near-significant p-value (P cons = 0.195) likely due to the low power arising from the small total number of genes and peaks within this trajectory.

Despite common claims in practice, core training did not demonstrate significant improvements in maximal strength, and showed only near-significant effects on vertical jump performance while demonstrating limited or non-significant effects on speed, flexibility, change of direction, technical skills, and throwing performance.

Only adjusted p -values are reported and an adjusted p -value cutoff of 0.05 was used for determining statistical significance while adjusted p -values between 0.05 and 0.10 were considered “near-significant.” General data processing was performed using Python version 3.9.10 ( Van Rossum and Drake Jr, 1995 ), Numpy version 1.23.4 ( Harris et al., 2020 ), and Pandas version 1.5.1 ( McKinney, 2010 ; The pandas development team, 2022 ).

Analyses used to examine the benefit of including variables such as anxiety that were consistent and showed near-significant results across models did not provide results that were statistically significant in the reduced model, so they were not incorporated into the final predictive model.

The near-significant contribution of Normalized y-Jerk in WS3 further suggests that reduced movement smoothness may compromise writing efficiency under higher cognitive load.

Whereas, the L allele in rs1421811 LD block drove a near-significant increase of NPR3 expression and elevated cell proliferation, but not migration ( Supplementary Material, Fig.

This near-significant trend likely reflects limited statistical power in the restricted glaucoma cohort rather than an absence of association, as supported by the consistent direction and effect size observed in the full-cohort sensitivity analysis ( Supplementary Table S2 , Supplementary Fig.

To facilitate interpretation and transparent reporting of the results, the following graphical outputs are pre-specified as part of the analytical plan: (a) Receiver Operating Characteristic (ROC) curves displaying sensitivity versus 1-specificity for each individual biomarker showing significant or near-significant bivariate associations with treatment response, as well as for the combined multivariable models (Elastic Net and Random Forest), enabling visual comparison of univariate versus multivariate discriminative performance; (b) a dot plot or bar chart of variable importance scores derived from the Elast

Table 4 and Figure 1 summarize the inferential parameters for the ROI where significant or near-significant differences were observed in women. 3.4.

Finally, in all statistical analyses, significant differences were declared at P ≤ 0.05, while 0.05 < P ≤ 0.15 were considered near-significant trends.

In addition, a greedy approach was taken, in which the fold-change of near-significant DEGs (fold-change >4), meeting the aforementioned quality criteria, were also included to more closely examine the expression behavior of genes annotated to specific canonical signaling pathways of interest, identified in Figure 2a (see Figure 2b ).

Age was found to be a near-significant predictive variable, while smoking and WTW were not found to be significant predictors of IOP change after CEIOL.

Discussion Our study demonstrates that periodontal inflammation (measured as BOP) and severity (measured as PIRIM) are associated with a higher cardiovascular risk, measured by LDLC, HDLC, CRI-1, CRI-2 and a near-significant association between PIRIM and AIP.

In particular, our (near-significant) results regarding the analysis of adjuvant systemic treatment, as well as those of the separate analysis of subcohorts with different counts of treated metastases, could both benefit from larger sample sizes, in order to clearly define the potential influence of these factors on PFS and OS.

Multivariable regression analysis further confirmed that longer diabetes duration, higher LDL levels, and elevated baseline HbA1c were significant predictors of HbA1c change, while the treatment group showed a near-significant independent effect.

There was a significant interaction ( P < 0.001) between distractor number and pattern in 1b ( Figure 2 , right panel), noteworthy given the near-significant interaction in 1a.

Additionally, we performed a multivariate logistic regression analysis; the results indicated that while there was no significant effect of sex on the BA profiles, age may have an influence, as suggested by a near-significant difference(Table S4 ).

Drugs that caused significant increases in dRnh1-GFP focus-positive cells (aphidicolin, HU, and idarubicin) also caused near-significant increases in the Pearson's coefficient for dRnh1-GFP/S9.6 overlap ( Supplementary Fig. 6e ).

This near-significant difference supports the reliability of RAS as a practical screening tool in resource-limited clinical settings. 4.1 Comparison with previous studies in Central Asia Our findings fill an essential gap in the existing literature for this region.

A near-significant opposite trend was observed in the complementary group, high core/low non-core (aFMT – high core/low non-core = 2.4 ± 1.5 kg, placebo – high core/low non-core = 0.87 ± 1.4 kg, P = .052).

Variables demonstrating theoretical relevance and significant or near-significant bivariate associations were entered into the model.

These increased development rates, and associated near-significant improvements of survival rates, occurred despite the on average 15% higher C/N ratios (i.e. presumed lower nutritional quality) of field margin nettles.

No significant differences were found in AVLT measures of short-term memory span (the first trial), learning process (sum of tests 1–5), or general index of encoding and retrieval (correct answers in delayed free recall trial), which suggests that the 2 groups do not differ in episodic memory, although some near-significant subtle differences were observed.

An additional near-significant component was found (p corrected = 0.055) which described activity in the premotor areas.

A lower expression of the MLH1 gene, which is also located on chromosome 3p, was significantly related to prognosis in one cohort and showed a near-significant effect in the other cohorts.