“nominally significant”

Lead and nominally significant SNPs ( p ≤ 0.05) for PCIF1 were examined.

For instance, while only the association between brain network connectivity and AF survived Bonferroni correction ( P < 2.62 × 10−4), several other phenotypes showed nominally significant associations ( P < .05) with CVDs, and also, to more flexibly balance the Type I and Type II errors, We applied a false discovery rate control to the results of all IVW methods (Table S4, Supplementary Digital content, https://links.lww.com/MD/P315 ).

For one haplotype combination, Haplo 1 (rs17700028 and rs12970134), the haplotype TDT was nominally significant (p≤0.05) in the detection as well as in the replication sample.

For each AD–cancer pair, we prioritized genes that were nominally significant in both traits ( p < 0.05) and exhibited inverse TWAS Z scores.

Of the 512, 142 (27.7%) had been tested by the IMPC and 64 (12.5% of the 512 prioritized genes, 45% of the 142 IMPC-tested genes) had a nominally significant (p ≤ 0.05) alteration of whole-body BMD in knockout/knockdown mice, compared to controls.

Three CpGs were nominally significant (p<0.05) in the Raine Study; none of the effect estimate confidence intervals contained zero and all had the same direction as ALSPAC.

We find that all 36 were at least nominally significant and 32 codes have a p -value < 0.05 and, after multiple testing correction, 25 of 36 ICD10 codes are significant in both cohorts, thereby indicating the consistency of our findings.

The mediating effects of three body fat indexes ( BMI, WHR and body fat percentage ), which were nominally significant in both models ( P < 0.05), were further evaluated for nature indirect effects ( NIE ) and nature direct effects ( NDE ) on the impact of age on diabetes oncome by VanderWeele's mediation approach 25 , 26 , 27 as follows: M B o d y _ f a t _ i n d e x e s = β 0 + β A g e ⋅ A g e + B ⋅ C o v a r i a

Most of the association information derives from the main effect test, but the intervention interaction tests have rather different P -values across these SNPs, with rs7705343 having nominally significant ( P < 0.05) interactions with each of E-alone, DMQ, and CaD, while interactions in relation to rs4415084 are not significant for any of the interventions.

The distribution of nominally significant ( P <0.05) associations between cancer-specific PRS and cognitive outcomes included inverse and positive associations, roughly as expected by chance.

The strongest haplotype effects were observed on HDL-C, followed by ApoB, comprising 19 and 18 nominally significant ( P <0.05) global P -values, respectively ( Supplementary Table 11 ).

In addition, we identified 61 genes that were nominally significant association ( P < 0.05) with both tau and amyloid deposition including APOE , TOMM40 , and COL5A2 ( P < 0.005) with both tau and amyloid pathologies (Supplementary Fig. 4 and Supplementary Table 13 ).

As none of the results were significant after this correction at FDR < 0.20 and given the exploratory nature of this study, all results nominally significant at p < 0.05 were deemed of interest and discussed accordingly.

However, the effects reported in Bäumler’s study [ 3 ] were small and nominally significant (two-tailed p < .05) only for bulkiness.

A nominally significant ( P < 0.05) positive correlation was also found with PTSD, whilst the estimate with GAD was a non-significant trend ( P = 0.052).

Two-sided p -values were considered significant for p < 0.001 to account for multiple testing, and nominally significant for p < 0.05.

We next mapped the nominally significant genes ( P < 0.05) calculated by VEGAS to the reference network.

Of the 21 variants, 6 were nominally significant (p < 0.05).

Leave-one-out Analyses To identify gene-based results driven by one or more variants, we applied the following leave-one-out strategy: 1- among the variants seen more than twice in our stage 1 sample (cases and controls together), we identified the variant with the lowest single-variant analysis p value whenever it is nominally significant (p < 0.05); 2- we removed this variant and performed the stage 1 gene-based test again.

Notably, the SNPs at 11q12.1 also are nominally significant (P<0.05) in the NFD subgroup, which is different from the observation for the SNPs at 6p21.32.

We identified a fully connected cluster of diseases where all pairwise genetic correlations were nominally significant (p ≤ 0.05).

Meta-analysis suggested that genetically proxied statin use was negatively associated with the order Actinomycetales, the family Actinomycetaceae, and the genera Actinomyces , Ruminococcus gnavus group , Eisenbergiella , and Erysipelatoclostridium at a nominally significant level ( P < 0.05) ( Figure 3 A ; Table S4 ).

16 , 18 , 88 We observed a further 30 nominally significant associations (p < 0.05), confirming previous MR findings of an increased risk of CAD, within the UK Biobank population ( Figure 3 , Table S16 ).

The associations remained nominally significant ( P <0.05) following an adjustment for intakes of other foods ( Table 2 ).

We had 80% power to detect nominally significant associations (p = 0.05) with SNPs that account for at least 0.8% of a trait's variance (full sample) or at least 1.0% of variance (individuals with MRIs).