“nominally significant”

A nominally significant ( P < 0.05) positive correlation was also found with PTSD, whilst the estimate with GAD was a non-significant trend ( P = 0.052).

We next mapped the nominally significant genes ( P < 0.05) calculated by VEGAS to the reference network.

Notably, the SNPs at 11q12.1 also are nominally significant (P<0.05) in the NFD subgroup, which is different from the observation for the SNPs at 6p21.32.

We had 80% power to detect nominally significant associations (p = 0.05) with SNPs that account for at least 0.8% of a trait's variance (full sample) or at least 1.0% of variance (individuals with MRIs).

We find that all 36 were at least nominally significant and 32 codes have a p -value < 0.05 and, after multiple testing correction, 25 of 36 ICD10 codes are significant in both cohorts, thereby indicating the consistency of our findings.

Leave-one-out Analyses To identify gene-based results driven by one or more variants, we applied the following leave-one-out strategy: 1- among the variants seen more than twice in our stage 1 sample (cases and controls together), we identified the variant with the lowest single-variant analysis p value whenever it is nominally significant (p < 0.05); 2- we removed this variant and performed the stage 1 gene-based test again.

In addition, we identified 61 genes that were nominally significant association ( P < 0.05) with both tau and amyloid deposition including APOE , TOMM40 , and COL5A2 ( P < 0.005) with both tau and amyloid pathologies (Supplementary Fig. 4 and Supplementary Table 13 ).

The mediating effects of three body fat indexes ( BMI, WHR and body fat percentage ), which were nominally significant in both models ( P < 0.05), were further evaluated for nature indirect effects ( NIE ) and nature direct effects ( NDE ) on the impact of age on diabetes oncome by VanderWeele's mediation approach 25 , 26 , 27 as follows: M B o d y _ f a t _ i n d e x e s = β 0 + β A g e ⋅ A g e + B ⋅ C o v a r i a

However, the effects reported in Bäumler’s study [ 3 ] were small and nominally significant (two-tailed p < .05) only for bulkiness.

Of the 21 variants, 6 were nominally significant (p < 0.05).

16 , 18 , 88 We observed a further 30 nominally significant associations (p < 0.05), confirming previous MR findings of an increased risk of CAD, within the UK Biobank population ( Figure 3 , Table S16 ).

For region-level analyses, considering the 136 MR estimates, a Bonferroni-corrected P -value of 0.05/136 (3.676 × 10 − 4 ) was applied, while nominally significant findings were defined as p < 0.05.

None of these variants were genome-wide significant in either the sporadic or multiple consecutive miscarriage analysis, and only 14 (4.2%) and 11 (3%) were nominally significant ( P < 0.05) in the respective analyses (Supplementary Data 4 ), which is less than expected by chance (5%).

The associations remained nominally significant ( P <0.05) following an adjustment for intakes of other foods ( Table 2 ).

Genes were selected for correlation and PCA analysis if they displayed nominally significant changes in the QuantiGene Plex assay (p ≤ 0.05) as well as nominally-significant changes in either human lymphoblasts exposed to ethanol, mouse NS-5 cells exposed to ethanol, or PBLs from binge-drinking adolescent rats.

We identified a fully connected cluster of diseases where all pairwise genetic correlations were nominally significant (p ≤ 0.05).

The remaining nominally significant associations (P <0.05) were considered as having weak evidence .

Overall, we found nominally significant associations ( P -value < 0.05) with exons common to the intermediate and short transcripts (Table 2 ).

At one of the 13 CpGs reported by Kallak et al., we found nominally significant ( p < 0.05) differential DNAme associated with SSRI exposure status in the placenta in the same direction as the original cord blood association: higher DNAme in SSRI-exposed cases.

Meta-analysis suggested that genetically proxied statin use was negatively associated with the order Actinomycetales, the family Actinomycetaceae, and the genera Actinomyces , Ruminococcus gnavus group , Eisenbergiella , and Erysipelatoclostridium at a nominally significant level ( P < 0.05) ( Figure 3 A ; Table S4 ).

There were only a handful of nominally significant associations (i.e., uncorrected p < 0.05; Fig. 1 ; Table 2 ) .

Although this analysis did not yield any significant genes after multiple testing correction, 15 genes were nominally significant ( p < 0.05), corresponding to a 2-fold enrichment with respect to the null hypothesis (Supplementary Fig. 7c ).

Out of the 131 metabolites that passed quality control, 27 showed at least nominally significant correlation ( p-value < 0.05) with LTL when adjusting for age and sex in model 1 (Table 2 ).

Results From the 52 CpGs identified in blood and selected for replication, 15 CpGs showed nominally significant associations with type 2 diabetes in the Lifelines sample ( p < 0.05).

In the combined three cohorts, four single nucleotide polymorphisms in or near FTO, GNPDA2, NEGR1, and SEC16B loci showed nominally significant interactions with total fried food consumption on BMI (all P<0.05 for interaction).