“nominally significant”

A nominally significant interaction effect was observed in patients with hypertension ( P = 0.037) and in those with wide QRS ( P = 0.003) ( Table 6 ).

Perhaps in line with this idea, we did see a nominally significant benefit of vitamin D on biological age ( p = 0.037) before correcting for multiple testing.

An initial synthesis of the volume data from the left and right habenula using a paired samples t ‐test also supported this point: no significant interhemispheric differences for either the healthy samples ( t (24) = 1.443, p = .162, Cohen d = 0.289), or the patients with SCZ ( t (4) = −0.550, p = .612, d = −0.246); there appeared to be a nominally significant difference in MDD subgroup ( t (10) = 2.403, p = .037, d = 0.725), but it did not survive correction of multiple testing.

In contrast, the probabilities of transitioning from other PL states to PL state 3 were all increased, with the transition from PL state 4 to PL state 3 also showing a nominally significant difference (uncorrected p = 0.0376, Cohen’s d = 0.5201).

Longitudinal stratification of the CIPN phenotypes to examine links for neuropathy, identified nominally significant protective associations with the GSTM* null allele ( p -value = 0.038, OR = 0.55) and the presence of pain at month 2 of treatment, as well as a risk factor for pain related month 2 of treatment for individuals with the GSTT1* null allele ( p -value = 0.030, OR = 1.64).

When tested individually, both di- and tetranucleotides showed at least nominally significant signals (two-sided z -proportion test P = 0.038 and P = 3.7 × 10 –38 , respectively), but trinucleotides did not ( P = 0.95).

Among diabetic patients, a nominally significant difference in unadjusted event rates was observed (12% vs. 35%, p = 0.038), though this exploratory subgroup analysis requires cautious interpretation given the small sample and absence of adjustment for confounders. 4.1.

Additional sensitivity analyses showed that the cML-MA-BIC-DP method (OR 0.60, 95% CI 0.53–0.69, p = 3.85 × 10 −11 ) yielded a similar result to IVW and weighted median methods ( Table 5 ), while the association from MR-APSS method was nominally significant (OR 0.20, 95% CI 0.05–0.92, p = 0.038) ( Table 5 ; Supplementary Figure S2 ).

MR pleiotropy residual sum and outlier (MR-PRESSO) test identified 5 outliers for IBD, 1 for RA and 2 outliers for vitiligo ( Table S10 ), whereas exclusion resulted in a nominally significant association for vitiligo (OR, 95% CI: 0.827, 0.691–0.989), p -value = 0.038; Figure 4 a).

For the OR, FA showed a nominally significant negative association at the uncorrected level (β = − 0.187, t (110) = −2.084, p =.039), but this did not survive FDR correction (FDR adjusted q = 0.118).

Nominally significant positive associations were observed between the weighted PGS and maternal alcohol consumption at week 30 (ST17; beta = 0.067, se = 0.032, p = 0.039).

At a threshold of FIS ≥0.7, SERPING1 variant carriers had a nominally significant increased risk of NCEIS (HR, 3.29; 95% CI, 1.06-10.19; P = .039) and PAD (HR, 3.10; 95% CI, 1.29-7.45; P = .011), with the association for PAD remaining significant after Bonferroni correction ( Figure 2 C; supplemental Table 4 ).

0.25), corresponding to a nominally significant association (OR = 1.68; 95% CI: 1.05–2.67; p = 0.039).

The difference in lymph node reduction between groups had nominally significant association in this exploratory analysis (p = 0.039, independent-samples t -test), with a moderate-to-large effect size (Cohen’s d = 0.71) ( Figure 2 ).

Assessment for significance of an SOD2 (# Ala16 alleles)-by-deployment interaction term (adjusted for both components of the interaction) to evaluate for effect modification by deployment was nominally significant, p = 0.039.

We further note that rs73404538 is nominally significant in the Sierra Leone susceptibility GWAS ( P = 0.039, OR = 0.71) and in a meta-analysis of the Nigeria and Sierra Leone susceptibility GWASs ( P = 0.021) with a concordant direction of effect (Extended Data Table 4 ).

69 In the phase 3 CUPID B trial that investigated patients with CSU who were refractory to 3 months of omalizumab therapy, a nominally significant reduction in UAS7 from baseline compared with placebo (−14.4 vs −8.5; P =0.0390) was observed at week 24.

For those who identified as Southeast or South (SE/S) Asian, there was a nominally significant interaction ( p = 0.039; β = 0.358) with religious attendance ( Fig. 3 ).

Progression-free survival (PFS) was also significant ( p = 6.730 × 10 −3 ; q = 0.0143), disease-specific survival (DSS) was nominally significant but borderline after FDR correction ( p = 0.0399; q = 0.0532), and disease-free survival (DFS) was not significant ( p = 0.0903; q = 0.0903) ( Figure 4 , Table S3 ).

Results: Among the examined variants, only GDF5 rs143384 showed a nominally significant association with DDH ( p = 0.040), with the A allele more common in affected individuals.

In the GAMs analysis, two variables showed nominally significant effects: baseline PNS index ( P = 0.040, b splin e 1 = − 0.942 ) and gender ( P = 0.028, coefficient = − 0.1332 ), with partial effects illustrated in Figure 5 and full results reported in the Supplementary Materials ( Supplementary data online , Table S5 , Supplementary data online , Figure S10 ).

When examining all subjects, nominally significant associations between carrier-status and remission (p = 0.04) and PSS-14 scores (p = 0.04) were observed after correcting for treatment arm.

Longitudinal change in total recall performance was nominally significant ( p = 0.04) between the PiB + and PiB − groups, and total recall at baseline was also significantly different between groups ( p < 0.01) indicating, as expected, a more overt cognitive decline was present in the individuals with positive PiB scans.

PFDEA, PFNA and PFUA concentrations were found to be nominally significantly associated with a higher number of gestational weeks at delivery (PFDEA: β 0.36, 95% CI 0.03–0.69, p = 0.04; PFNA: β 0.34, 95%CI 0.01–0.66, p = 0.04; PFUA: β 0.34, 95% CI 0.05–0.63, p = 0.04) but were not robust to multiple testing correction ( Table 4 ).

8 In the multivariable Cox model reported by Ruhwedel et al., the overall effect of primary tumor location was not statistically significant ( p = .11), but there was a nominally significant association for shorter OS in patients with pancreatic versus gastrointestinal NETs during [ 177 Lu]Lu‐edotreotide therapy ( p = .04). 33 However, there are prognostic differences between NETs of different origin, depending on the aggressiveness of disease. 44 , 45 Overall, our findin