“nominally significant”

This association was nominally significant ( p = 0.04) in the Spanish cohort ( Mancama et al., 2007 ).

For example, in LiAc, GxE was seen for all reporters in that BY showed no significant change in UPS activity compared with SC for any reporter, while RM showed at least nominally significant reductions for all reporters ( t -test for effect of environment per strain, P ≤ 0.04).

ANN NEUROL 2025;98:1027–1043 Although WMH volume showed a nominally significant association with hippocampal volume ( p = 0.04) in the P‐tau181‐based BM‐CTL group, this did not remain significant after correction for multiple comparisons.

Regarding neural correlates, only the left temporal pole and anterior parahippocampal gyrus activation during failed inhibition—go contrast was nominally significantly ( p = 0.04) associated with symptoms of hyperactivity-impulsivity, so there was only one mediation model involving neural correlates and therefore no additional multiple testing correction could be applied here (see also under Methods).

Phyla-level phylogenetic binning of 16S rRNA data revealed a nominally significant correlation between the Bacteroidetes:Firmicutes ratio and age- and sex- adjusted BMI (r = 0.116; p = 0.04), but no significant correlation with metabolic syndrome traits [fasting glucose (r = 0.075; p = 0.19), systolic or diastolic blood pressure (r = 0.016; p = 0.78 and (r = 0.043; p = 0.45), respectively), fasting triglycerides (r = 0.078; p = 0.17), HDL-cholesterol (r = −0.052; p = 0.36); all adjusted for age and sex) Results from unweighted UniFrac analysis [16] also did not distinguish among the subjects based on BMI ( Figure S5 ).

In a meta-analysis of the two cohorts, the ACE polymorphism remained nominally significant ( P = 0.04).

At rs1477798 in 15q22.31 which showed evidence of linkage in clinic-based, larger families, a nominally significant case-control association was observed (OR 1.16, p = 0.04) which was modestly strengthened for cases with CRC family history (OR 1.24, p = 0.03); however, no significant difference in risk by family history was observed and associations were far from genome-wide significant.

When analyzing the time to gastrostomy based on the initial randomization group, the survival curves differed ( Figure 3 ) and Cox regression indicated a nominally significant difference (Likelihood Ratio Test, p = 0.040).

We did not find a significant association between severity of endometriosis and self-reported coeliac disease, neither did we find an association with self-reported lactose intolerance. The endometriosis PGS was not associated with defaecation pattern regularity ( P FDR = 1.00), though it did associate (nominally significant) with some of the gastrointestinal symptoms, i.e. abdominal pain (OR = 1.22, 95% CI = 1.01–1.47, p = 0.04, P FDR = 0.55) and pain during food intake (OR = 2.60, 95% CI = 1.28–5.29, p = 0.01, P FDR = 0.09).

Similarly, epistasis of olfactory behaviour was not significantly correlated with epistasis for day sleep and night sleep for Crc , and the correlation with waking activity in males was only nominally significant ( P= 0·04; Fig. 6 ).

Correlation of MS admissions with smoking prevalence There was a nominally significant inverse correlation with smoking but this was lost in the weighted regression ( figure 2a ; overall – r = −0.55, p = 0.04, r sw = −0.49, p = 0.08; r pw = −0.25, p = 0.39; figure 2b ; males – r = −0.52, p = 0.06, r sw = −0.47, p = 0.09; r pw = −0.21, p = 0.47; females – r = −0.56, p = 0.04; r sw = −0.49, p = 0.08; r pw = −0.25, p = 0.38).

In addition, we observed a nominally significant association (p = 0.04) with rs11209026, which is in agreement with the previously described effect on AS of the IL23R locus (Supporting Table S1 ) [4] .

COMT Val158Met was also nominally significant in this model (F (2,109) =3.4, p =0.04) (but see below for other model results).

SNP rs2630488 within GNRHR showed a nominally significant association (p = 0.04) with estradiol levels in post-menopausal women.

Longitudinal change in total recall performance was nominally significant ( p = 0.04) between the PiB + and PiB − groups, and total recall at baseline was also significantly different between groups ( p < 0.01) indicating, as expected, a more overt cognitive decline was present in the individuals with positive PiB scans.

When examining all subjects, nominally significant associations between carrier-status and remission (p = 0.04) and PSS-14 scores (p = 0.04) were observed after correcting for treatment arm.

Although PCSK1 rs6235 was not significantly associated with diabetes in the age- and sex-adjusted models ( P = 0.21), additional adjustment for BMI rendered a nominally significant protective effect for this variant ( P = 0.04).

For LOX1.3, the minor allele showed a nominally significant association with clinical CHD but in the opposite direction than that seen in the ADVANCE study (HRR 0.92, P = 0.04 for the additive model).

Four carriers of codon 60R had decreased insulinogenic index (β = −83% [−152 to −13], P = 0.02) ( Table 5 ), which remained nominally significant when analyses were adjusted for the difference in BMI (β = −72% [−140 to −5], P = 0.04). 243R was nominally associated with decreased FPG (β = −0.08 mmol/l [−0.16 to −0.01], P = 0.04) ( Table 5 ).

In exploratory subgroup analyses, ulcerative ileocolitis showed a nominally significant genetic association with perianal disease ( p = 0.04).

At the subcortical level, a nominally significant uncorrected effect was observed for HC versus ET in the left thalamus ( p = 0.04, uncorrected, t = −2.07), with sub-threshold trend-level uncorrected effects in HC versus LTG ( p = 0.12, uncorrected, t = −1.58) and HC versus HTG ( p = 0.06, uncorrected, t = −1.91).

Among the more common ( n ≥ 5) movement disorders, only a higher proportion of dyskinesia in antipsychotic‐naïve individuals was nominally significant (antipsychotic‐naïve vs. ever‐exposed, 4/9 (44%) vs. 2/22 (9%), p = 0.04) (Table 4 ).

That being said, there was a nominally significant association (OR = 1.26, p -value = 0.04) of the PRS-CRP constructed using a limited number of genome-wide significant SNPs, mimicking the one used by Huang et al. 8 , with moderate-to-severe OSA with EDS, compared with no OSA.

CAV1, PDPN, and ZFPM2 also demonstrated nominally significant differences across specific age group comparisons (p ≤ 0.040), though their patterns were comparatively less consistent.

We find that the two depressive symptoms lead-SNPs have the predicted sign for subjective well-being, and one is nominally significant ( p = 0.04).