“nominally significant”

However, results of the enriched Amerindian or African variants’ interaction with APOE -ɛ4 on MCI analysis, the BinomiRare test identified one nominally significant interaction between an African enriched variant, rs8112679, and APOE -ɛ4 on MCI ( p -value = 0.017) (Table 4 ).

The two variants were not genome-wide significant in our study, but nominally significant into the same direction (p = 0.018 and p = 0.003).

However, schizophrenia was nominally significantly associated with an earlier AgeSmk (OR = 0.99, 95% CI = 0.98–0.998, p = 0.02) using the IVW method.

For the third approach using the correlation between expression and DNA methylation, 4 genes showed a nominally significant correlation between expression and methylation: AES (Spearman rho=-0.54, p =0.02), SAR1A (Spearman rho=0.50, p =0.03), CRYBG2 (Spearman rho=0.47, p =0.04), and S1PR4 (Spearman rho=-0.48, pval=0.04).

The signal in the CR1 locus, chr1q.32.2 (rs679515, P = 2.7 × 10 –08 , β = 0.15, SE = 0.03, MAF = 0.18) was in high LD (R 2 = 0.97) with previously observed signal in the NHW and multi-ethnic meta-analysis (chr1q.32.2), also remained significant in the APOE ɛ4+ strata, but only nominally significant in the APOE ɛ4- (P = 0.02, β = 0.05, SE = 0.02).

In the largest GWAS on nucleus accumbens volume, 7 this variant was nominally significant ( p = 0.02), showing the improved power of our current study to identify novel brain morphometry loci.

We observed nominally significant genetic correlation between BAG and AD that did not survive FDR-correction ( r = 0.23, SE = 0.1, p = 0.02, FDR adjusted p = 0.13) and no significant associations with any other of the four disorders (Fig. 2a ).

Changes in Oscillibacter counts were nominally significantly associated with changes in concentrations of the inflammatory markers hsCRP (ρ=0.433, p=0.02), neutrophils (ρ=0.508, p=0.007), and resistin (ρ=0.554, p=0.003), while correlations with GlycA (ρ=0.370, p=0.057) and WBC (ρ=0.355, p=0.07) trended towards but did not reach nominal statistical significance ( Fig. 5 ).

Moreover, the IVW model showed a nominally significant positive correlation between mood swings (OR: 1.578; 95% CI: 1.062–2.345; P = 0.024) and UFs risk.

The meta-analysis of the replication cohorts, where the variant was present, was nominally significant and showed a consistent direction of effect with the discovery sample (OR 1.18 [95% CI 1.02, 1.36], p =0.025) (Fig. 3 c, ESM Table 5 ).

MR analyses showed a nominally significant causal effect of WHRadjBMI on pancreatic cancer (OR[95%CI] = 1.00095[1.00011–1.0018], P = 0.027) but not for BMI on pancreatic cancer.

There was a nominally significant association between endothelial cell loss and APOE ε4 homozygous genotype ( b = −9.6 × 10 −2 , SE = 4.3 × 10 −2 , P = 2.7 × 10 −2 ), which remained when restricting to only controls ( b = −9.9 × 10 −2 , SE = 4.7 × 10 −2 , P = 4.3 × 10 −2 ; n = 511), adjusting for baseline covariates.

PSC In accordance with the cis-pQTL definition, a nominally significant association was observed between genetically predicted C8G (IVW, OR: 0.832, 95% CI 0.707–0.979; P =0.027) and CFHR5 (IVW, OR: 1.193, 95% CI 1.048–1.357; P =0.007) in relation to the risk of PSC ( Fig. 2 ).

For example, while GDNF and GPR15 expression data did not pass QC filtering, GNG12 expression was successfully measured and displayed a modest and nominally significant inverse correlation with GNG12 cg25189904 (r = −0.143, p = 0.027).

Furthermore, primary lung cancer patients demonstrated a nominally significant increased odds of having made a serious smoking quit attempt compared to both MSC-1 and LSC-1 controls, with odds ratios of 1.44 (p = 0.028) and 1.42 (p = 0.026), respectively.

Age and sex adjusted MaAslin model indicated that Fusobacteria was nominally significant ( p = 0.029 ) with beta 0.685 (se 0.33) but multiple testing corrections turned to null ( q = 0.309 ) (Supplementary Table 5 ).

However, MVMR was suggestive of a nominally significant causal association between genetically susceptible CHB and severe COVID-19 (OR = 1.12, 95% CI 1.01–1.23, P = 0.029) (Table 3 ).

There was a nominally significant excess of heart failure (HR 1.34, 95% CI:1.03 to 1.75, p=0.03) but no associations with other studied cardiac outcomes.

Of the seven individual mutations observed in more than 2% of tumors, we observed nominally significant higher frequency of the E545K hotspot mutation in PIK3CA (13.7% vs. 7.5%, Fisher exact test P value = 0.03) and a nonsignificant trend toward higher frequency of the splice variant in GATA3 (4.8% vs. 1.9%, Fisher exact test P value = 0.07) in H/L compared with TCGA Whites (Supplementary Table S5).

The treatment effect for 360 mg, every 2 weeks vs placebo was nominally significant (−16.3%; nominal P = .03); however, significance could not be claimed because the hierarchical testing sequence was interrupted.

Although 2-component systems did not reach the FDR 0.1 threshold in DINE-CD, it was nominally significant at P = .03.

A nominally significant similar relationship was observed for the right amygdala, though this did not survive multiple comparison correction (Figure 4b ; Table 2 ; t = −2.2; p = .03, q = 0.06).

Type 1 diabetes was nominally significant in IVW analysis in relation to POAG ( p = 0.03) but no statistically significant signals were obtained for this trait by the other MR methods used in this study (weighted median p = 0.07, weighted mode p = 0.10, MR Egger p = 0.19).

There was a nominally significant relationship between TL and preeclampsia (PE) in the IVW model (OR: 0.799; 95% CI: 0.651-0.979; P = 0.031).

Supplementary data thorax-2023-220856supp002.xlsx Causal estimate for seropositive RA on IPF The primary IVW-FE analysis gave a nominally significant result for a protective causal effect of seropositive RA on IPF (OR 0.93; 95% CI 0.87 to 0.99; p=0.032) ( figure 2A and online supplemental table 6A ).