“nominally significant”

Moreover, the IVW model showed a nominally significant positive correlation between mood swings (OR: 1.578; 95% CI: 1.062–2.345; P = 0.024) and UFs risk.

The meta-analysis of the replication cohorts, where the variant was present, was nominally significant and showed a consistent direction of effect with the discovery sample (OR 1.18 [95% CI 1.02, 1.36], p =0.025) (Fig. 3 c, ESM Table 5 ).

In the secondary analysis, we found a nominally significant causal association between zinc and osteomyelitis (OR = 1.13, 95%CI = 1.02 to 1.27; p = 0.0252) and a strong causal association between vitamin B6 and osteomyelitis in the secondary analysis (OR = 2.78, OR 95%CI = 1.34 to 5.76; p = 0.0060).

There was a nominally significant association between endothelial cell loss and APOE ε4 homozygous genotype ( b = −9.6 × 10 −2 , SE = 4.3 × 10 −2 , P = 2.7 × 10 −2 ), which remained when restricting to only controls ( b = −9.9 × 10 −2 , SE = 4.7 × 10 −2 , P = 4.3 × 10 −2 ; n = 511), adjusting for baseline covariates.

For example, while GDNF and GPR15 expression data did not pass QC filtering, GNG12 expression was successfully measured and displayed a modest and nominally significant inverse correlation with GNG12 cg25189904 (r = −0.143, p = 0.027).

MR analyses showed a nominally significant causal effect of WHRadjBMI on pancreatic cancer (OR[95%CI] = 1.00095[1.00011–1.0018], P = 0.027) but not for BMI on pancreatic cancer.

In PSP, we observed a nominally significant enrichment in oligodendrocyte enhancer sequences ( P = 0.027) (Fig. 1b ).

PSC In accordance with the cis-pQTL definition, a nominally significant association was observed between genetically predicted C8G (IVW, OR: 0.832, 95% CI 0.707–0.979; P =0.027) and CFHR5 (IVW, OR: 1.193, 95% CI 1.048–1.357; P =0.007) in relation to the risk of PSC ( Fig. 2 ).

Furthermore, primary lung cancer patients demonstrated a nominally significant increased odds of having made a serious smoking quit attempt compared to both MSC-1 and LSC-1 controls, with odds ratios of 1.44 (p = 0.028) and 1.42 (p = 0.026), respectively.

Age and sex adjusted MaAslin model indicated that Fusobacteria was nominally significant ( p = 0.029 ) with beta 0.685 (se 0.33) but multiple testing corrections turned to null ( q = 0.309 ) (Supplementary Table 5 ).

However, MVMR was suggestive of a nominally significant causal association between genetically susceptible CHB and severe COVID-19 (OR = 1.12, 95% CI 1.01–1.23, P = 0.029) (Table 3 ).

There was a nominally significant excess of heart failure (HR 1.34, 95% CI:1.03 to 1.75, p=0.03) but no associations with other studied cardiac outcomes.

Of the seven individual mutations observed in more than 2% of tumors, we observed nominally significant higher frequency of the E545K hotspot mutation in PIK3CA (13.7% vs. 7.5%, Fisher exact test P value = 0.03) and a nonsignificant trend toward higher frequency of the splice variant in GATA3 (4.8% vs. 1.9%, Fisher exact test P value = 0.07) in H/L compared with TCGA Whites (Supplementary Table S5).

A nominally significant similar relationship was observed for the right amygdala, though this did not survive multiple comparison correction (Figure 4b ; Table 2 ; t = −2.2; p = .03, q = 0.06).

Type 1 diabetes was nominally significant in IVW analysis in relation to POAG ( p = 0.03) but no statistically significant signals were obtained for this trait by the other MR methods used in this study (weighted median p = 0.07, weighted mode p = 0.10, MR Egger p = 0.19).

The treatment effect for 360 mg, every 2 weeks vs placebo was nominally significant (−16.3%; nominal P = .03); however, significance could not be claimed because the hierarchical testing sequence was interrupted.

Although 2-component systems did not reach the FDR 0.1 threshold in DINE-CD, it was nominally significant at P = .03.

There was a nominally significant relationship between TL and preeclampsia (PE) in the IVW model (OR: 0.799; 95% CI: 0.651-0.979; P = 0.031).

Supplementary data thorax-2023-220856supp002.xlsx Causal estimate for seropositive RA on IPF The primary IVW-FE analysis gave a nominally significant result for a protective causal effect of seropositive RA on IPF (OR 0.93; 95% CI 0.87 to 0.99; p=0.032) ( figure 2A and online supplemental table 6A ).

GlycanAge was significantly lower in the active group compared to the inactive group (β = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (β = 7.546, p = 3.20E-02).

RGS4 was significantly expressed in the coronary artery tissue according to GTEx data (median transcripts per million =18.23), although rs10799925, an intergenic lead variant, and RGS4 expression showed only nominally significant eQTL association (normalized effect size =−0.150; p =0.032).

meta-analysis ( 29 ), only ARRDC3 passed a Bonferroni-corrected P value threshold ( P = 0.00035), while WSCD1 was nominally significant ( P = 0.032); one of the Falconnier et al. genes had been filtered out during quality control processing in Carter et al.

When women with early menopause were added, breast cancer risk remained increased and ovarian cancer was also nominally significant (3.38 [1.15, 8.65]; p=0.032).

The association with previous VTE for one SD increase in CFHR5 level in VEBIOS Coagulation was still nominally significant when adjusting for C3 levels (OR 1.36 [CI 1.03-1.82], p = 0.032), although weaker compared to adjusting only for age and sex (OR 1.55 [CI 1.2-2.01], p = 8.85E-04, Table 3 and Supplementary data 1 [Tab_8] ).

11 We only found a nominally significant association of rs10191329 with the yearly change rate of the lateral ventricles ( p = 0.032), but not with any of the other 14 investigated metrics, including yearly change rates of the total brain volume ( p = 0.690), thalamus ( p = 0.953), or putamen ( p = 0.613).