“nominally significant”

Some nominally significant correlations (uncorrected p < 0.05) were also observed in AN and BN groups (details in the Online Supplementary Material, Tables S1-S3).

In eyes with serous PED at baseline, faricimab resulted in a greater decrease in maximum PED thickness throughout head-to-head dosing compared with aflibercept ( Fig 1 B), with nominally significant differences (nominal P < 0.05) at weeks 4 and 12.

To identify metabolomic biomarkers independent of conventional risk factors including DKD, metabolites remaining nominally significant ( p <0.05) after further adjusting for CKD and severely increased albuminuria were assessed for the prognostic value.

Consequently, selected mediators were also required to have at least nominally significant ( p < 0.05) causal effects from the exposure and to the outcome.

Fourteen out of twenty-eight selected SNPs showed nominally significant associations at p <0.05 with different dimension-specific quantitative assessments of psychotic experiences but each failed to meet statistical significance post correction for multiple testing ( p <0.0008; one-tailed).

Whenever applicable, a gene should show nominal significance (unadjusted p -value ≤ 0.05) and a concordant directionality for the effect estimate in sensitivity analyses, including the weighted median, MR-Egger, and MR-PRESSO, while the MR-Egger intercept should not be nominally significant ( p -value ≥ 0.05).

For the loci that explained a significant proportion (nominally significant SNP heritability estimate, P < 0.05) of the total SNP heritability of F gRI-D and white matter tracts, we proceeded to perform bivariate local genetic correlation.

To avoid complex causality relationships, we excluded the results that showed a nominally significant MR estimate in the other direction ( P < 0.05).

In addition, we performed a variety of sensitivity analyses for significant or nominally significant results.We used Cochran’s Q test and MR multivariate residual sums and outliers (MR-PRESSO) test to calculate the potential heterogeneity, where p < 0.05 indicated the presence of heterogeneity [ 31 ].

Studies) below Metabolome Wide Significance Level (MWASL) threshold (p = 2.4 * 10E–9 to 1.1 * 10E–5) with Ln[CACs + 1] mannose, alanine and acetaminophen-glucuronide strongly associated yet glutamate and histidine had strong inverse associations besides other significant metabolites also remained nominally significant (p < 0.05) but by 50% weaker association; furthermore, lipoprotein subcategories of total plasma cholesterol, total plasma apolipoprotein B and apolipoprotein B within total plasma LDL significantly associated with Ln[CACs + 1] in model-3 (further adjusted for model-1 + nonlipid CVD risk factors of SBP, DM, Smoking status, and use of medication for hypercholesterolemia, BP or DM).”.

Polygenic scores for behavioural traits None of the associations between PGSs for behavioural traits and SUD-related phenotypes surpassed multiple testing corrections, however, nominally significant associations ( p < 0.05) are detailed bellow.

Potential causal traits were required to (1) pass heterogeneity/pleiotropy checks, (2) lack bidirectional effects, and (3) be nominally significant ( P < 0.05) with consistent effect direction across all MR sensitivities.

Pearson correlation and group-based comparisons identified ten compounds with nominally significant associations associated with CDH2 expression ( p < 0.05) ( Figure 10 ).

None of these were nominally significant in the full UKBB dataset ( p -value > 0.05).

Among the pAIDs examined where the SNP- h 2 estimates were at least nominally significant ( P <0.05), T1D and juvenile idiopathic arthritis (JIA) were the most highly heritable ( Fig. 1b ).

Tier 1 findings included putative causal associations from the main analysis, which were directionally consistent, at least nominally significant in all analyses and showed no evidence of pleiotropy, that is, the Egger intercept P value >0.05, whereas tier 2 included the remainder of putative causal associations from the main analysis.

For 2 variables (pre-BD FVC, lower in mild asthmatics from Canada; and PC20, trend for lower values in Romania), there were nominally significant interactions ( p < 0.05) between region and asthma severity cohort that did not pass multiple testing corrections with FDR < 0.05.

For each refitted model, the fixed-effect estimate of the group-by-time interaction was extracted, and summary metrics were computed, including the range and mean of the estimated effects (β), the mean p -value, and the number of iterations in which the effect remained nominally significant ( p < .05).

In contrast, the mean intensity of PC was inversely associated with TNFR2 and VCAM-1, whereas Cer(d) was positively associated with fibrinogen, and PE(O) was negatively associated with TNFR2; however, these correlations were only nominally significant ( P < 0.05).

Among the top 10 features associated with schizophrenia, we identified three instances of feature-to-schizophrenia risk causal flow with nominally significant p-values (p < 0.05), and six instances in the opposite direction.

Discussion In a population with chronic mental illness, various SNPs in 10 candidate genes ( PPP1R1B , BDNF , DRD3 , DRD2 , HTR2A , HTR2C , COMT , MnSOD , CYP1A2 , and RGS2 ) reached nominally significant (p≤0.05) associations with drug-induced movement disorder.

Three MR models (IVW, weighted median, and GSMR) demonstrated nominally significant ( p < 0.05) causal effect of IPF on CAD, with the estimated liability-scale odds ratios (ORs) ranging from 1.08 to 1.38 (Table 2 ).

Of the nominally significant single‐cell SMR associations ( P <0.05), >75% (Figure 2E ) were not detected in the corresponding GTEx brain tissue SMR analyses.

Nevertheless, the sign and estimates of the effect sizes were all consistent, and most of the relevant associations were found nominally significant (P < 0.05).

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.