“nominally significant”

There was nominally significant evidence overall that the male ORs differed from those for ER-positive female disease (p = 0.05).

Of the 1,291 adult BMI variants compared, 395 variants (31%) were nominally significant ( p < 0.05) and 949 (74%) displayed directionally consistent associations with childhood BMI, which was far greater than would be expected by chance ( p < 0.001) ( Table S6 ).

A nominally significant association was observed for females with %AFR of ≥ 95% compared with those who had %AFR of 55.0–64.9% (OR: 1.42, 95% CI: 1.00–2.03, P = 0.05).

In patients with moderate or severe DED ( n = 53), PL9643 treatment demonstrated either nominally significant ( P < 0.05) or trending ( P < 0.1) improvement over placebo in mean change from baseline at week 12/day 85 in several sign endpoints, including fluorescein staining in inferior, superior, corneal sum, and total sum regions; Lissamine Green staining in temporal, nasal, conjunctival sum, and total sum regions; and tear film breakup time.

Among all the allele contrast meta-analysis, 21 (30%) polymorphisms in 19 genes showed nominally significant associations with HCC risk ( P-value < 0.05).

In SMR analyses of gene expression and migraine within the Finnish cohort, six genes—EP300, HDAC3, SIRT1, AARS2, SLC16A1, and SMARCA4—showed nominally significant associations ( P < 0.05).

In all volcano plots and figure captions, metabolites surviving FDR correction (q < 0.05) are visually distinguished from those that are nominally significant only ( p < 0.05, uncorrected).

330 CpG sites annotated to candidate genes were retrieved and screened for nominally significant longitudinal effects ( p < 0.05).

Of the 13 assayed proteins, only 3 showed nominally significant difference (p<0.05) after the swimming experiment (CCL11, and CXCL10 lower and IL-1ra, higher).

In addition, rs713998 showed a nominally significant ( P < 0.05) association with verbal memory, and this association did not remain after Bonferroni correction (verbal memory subtest score: A/A and A/G = −1.74 ± 1.28, G/G = −2.19 ± 1.31, β = 0.210, t = 2.704, permutation P value = 0.029).

Nonetheless, several ICs showed nominally significant associations (uncorrected p < 0.05).

Only the volumes of the caudate, corpus callosum and third ventricle achieved a heritability that was nominally significant in our sample (uncorrected P <0.05).

Tier 1 findings included putative causal associations from the main analysis, which were directionally consistent, at least nominally significant in all analyses and showed no evidence of pleiotropy, that is, the Egger intercept P value >0.05, whereas tier 2 included the remainder of putative causal associations from the main analysis.

To identify metabolomic biomarkers independent of conventional risk factors including DKD, metabolites remaining nominally significant ( p <0.05) after further adjusting for CKD and severely increased albuminuria were assessed for the prognostic value.

Some nominally significant effects were observed (i.e., covariate-adjusted differences between genotype groups at p < 0.05).

Eight of the 13 ALFRED genes with a nominally significant association between RDGVs and AI in at least one cancer type in the ALFRED analysis ( P < 0.05; Fig. 2d and Supplementary Data 5 ) also had an enrichment of RDGVs in a matched cancer type compared to in controls ( P < 0.05, Fig. 3d ; Supplementary Data 6 ): ATM in colon and rectum adenocarcinoma (COADREAD), lung adenocarcinoma (LUAD) and in PRAD, NSD1 in OV, and TPCN2 in uterine corpus endometrial carcinoma (UCEC).

RESULTS: Six BMI loci ( TMEM18, NUDT3/HMGA1, FAIM2, FTO, MC4R and KCTD15 ) and two WC/WHR loci ( VEGFA and ITPR2-SSPN ) were nominally significant (P< 0.05) at the index or proxy SNP in the corresponding BMI and WC/WHR models.

This analysis initially identified 216 KO genes with nominally significant differential abundance (nominal p < 0.05) between healthy and diseased rhizosphere samples.

Finally, the excess statistical significance test was used to evaluate whether the observed number of studies ( O ) with nominally significant results ( p < 0.05) exceeded the expected number ( E ) ( 26 ).

We then applied sensitivity analyses for nominally significant results ( P -value < 0.05), namely: heterogeneity test (Cochran’s Q), horizontal pleiotropy (MR Egger intercept), detection of outliers with MR Pleiotropy Residual Sum and Outlier test (MR-PRESSO v1.0) 46 and directionality validation.

While these results were nominally significant (p < 0.05), they did not maintain statistical significance after Hochberg correction.

Moreover, 113 blood metabolites and six inflammatory factors showed nominally significant causal associations with LC risk ( P < 0.05).

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.

We note that although APOE has previously been identified as a AD TWAS gene in microglia 83 , we did not highlight it in our scTWAS results because it did not pass Stage 1 screening, despite nominally significant Stage 2 associations in proliferate, surveilling, and reacting microglia (nominal p -values < 0.05).

As shown in Supplementary Table 1 , group-wise DE genes cover only a small fraction of the asthma-related pathways: only 7 out of 35 pathways show nominally significant enrichment (uncorrected p -value < 0.05, Fisher’s exact test); after Bonferroni correction, only two pathways remain.