“nominally significant”

Causal estimates produced by the different methods had consistent direction of effect compared to the IVW estimate and all save MR-Egger were nominally significant (i.e. p < 0.05).

However, we registered nominally significant (at an unadjusted p < 0.05) interethnic variability in the abundance of seven metabolic pathways, ten species, and four microbial families: Peptostreptococcaceae , Aerococcaceae , Bifidobacteriaceae , and Leptotrichiaceae ( Table S5 ).

Although 129 associations were nominally significant based on raw p values ( p < 0.05; Fig.

In summary, sex was nominally significant ( p -value < 0.05) for most bins and scores, except for the anxiety-depression scores of the 13 and 14-year age group ( p -values = 0.78 and 0.91).

Three sites (hand, head, shoulder) showed nominally significant associations ( p < 0.05) between baseline PA patterns and subsequent pain outcomes (Supplementary Tables 17 – 23 ).

Only one of these SNPs showed a nominally significant association ( P < .05) in our data (rs909253, proxy for rs1041981, r 2 = 0.93; OR = 1.12; P = .005).

Differential gene expression analyses of CD11b + cells in VAT and SAT from individuals with obesity revealed nominally significant differences in the gene expression profile (FDR p < 0.05, absolute fold change > 1.5; Figure 1A,B ).

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.

If such interaction was nominally significant ( P < 0.05), the analysis was conducted separately in cases and control subjects (eg, after stratifying by asthma).

Depending on the model type selected, between 8% and 19% of protein pairs exhibited a nominally significant correlation ( P < 0.05) between predicted and observed expression/co-expression in all three models, but this percentage rose to over 99% in well-imputed pairs.

When the Saline Solution group was compared with the remaining groups, the mean difference was 0.96667 versus SP Gel ( p = 0.474) and 3.17333 versus SP Macerate (standard error = 1.39615; p = 0.031), with the latter representing the only nominally significant difference ( p < 0.05).

Of the 21 loci, 13 were nominally significant (p<0.05) in UKBB, including one variant (rs4388642 in CFH, p=1.82×10 -17 ) reaching Bonferroni-corrected significance (Supplementary file Table S3).

However, within specific strata, exploratory observations showed nominally significant negative correlations ( P < 0.05) in participants with/without health insurance, among Other Hispanic individuals, and in those with low neutrophil counts, low SII/AISI scores, or pre-frailty/frailty status, both before and after adjusting for age, household education, and PIR (Table S4).

Seven genera showed nominally significant IVW associations with endometriosis ( P <0.05): Lactococcus , Olsenella , Senegalimassilia , Ruminococcaceae UCG-002, Holdemania , Eubacterium ruminantium group and Anaerotruncus .

We note that although APOE has previously been identified as a AD TWAS gene in microglia 83 , we did not highlight it in our scTWAS results because it did not pass Stage 1 screening, despite nominally significant Stage 2 associations in proliferate, surveilling, and reacting microglia (nominal p -values < 0.05).

Genes nominally significant in the MAGMA analyses ( P Bonf < P < 0.05) were meta-analysed using Stouffer’s method.

For the most part, gene expression profiles were quite similar with only 329 genes showing differential expression at a nominally significant p-value (p<0.05), of which 63 remained significant after correcting for genome-wide analysis (FDR <0.05).

In a per-protein analysis, replacing values below the limit of detection with protein specific LOD-values, five proteins (CSF-1, NTRK3, ICOSLG, SCF and PECAM-1) were found to have nominally significant differences between the two time-points (p < 0.05, Wilcox test).

Interestingly, SCZ showed a nominally significant proportion of caQTL-mediated heritability in LCLs (p<0.05, MESC), consistent with the hypothesis that B cells may play some role in SCZ pathogenesis ( Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014 ; van Mierlo et al., 2019 ).

Six of the 23 clinical symptom categories showed nominally significant differences between the carrier and control groups ( p < 0.05, chi-squared test).

3 ), with similar but only nominally significant ( p < 0.05) findings observed for the separate autologous ( p = 0.018) and allogeneic ( p = 0.015) subgroups.

Two variants were nominally significant ( p < 0.05) with a consistent direction of effect for at least one decline phenotype (Table 3 ).

Three out of 11 HbA 1c -associated SNPs had nominally significant ( p < 0.05) associations with HbA 1c levels in at least one of the three race-ethnic groups, but altogether only four of the 33 possible associations (11 SNPs x three race-ethnic groups) were significant ( p < 0.05).

Lead and nominally significant SNPs ( p ≤ 0.05) for PCIF1 were examined.

Markers with nominally significant p-values in one or more cell populations ( P ≤ 0.05; e.g CD39, CD38, Ki-67, PD-1) were visualized in boxplots; statistical significance computed using the linear mixed model were further confirmed using non-parametric Wilcoxon rank sum test.