“nominally significant”

Effect estimates for most proteins remained consistent after adjustment for these factors, but standard errors increased such that only Nt-proBNP, CXCL13 and the complement factors remained significant at the Bonferroni-adjusted threshold (Table 2 ) although all proteins except IL-1RA and tPA remained nominally significant at p < 0.05.

Lastly, we summarized available corresponding observational evidence for identified associations between IDPs and pain-related phenotypes. LDSC regression analysis We used LDSC to evaluate the genetic correlations between 587 structural IDPs and 13 pain-related phenotypes, of which 559 IDP–pain pairs displayed nominally significant genetic correlations ( P < 0.05) ( Figure 2 ).

Results Nominally significant evidence for association (p < 0.05) was found for seven markers (D5S0023i, IL9, RH60252, 5Q3133_33, D5S2017, D5S1481, D5S0711i) which were then individually genotyped in the trios.

At the nominally significant threshold ( P < 0.05), it was also associated with an increased risk of six other gene-specific CH subtypes but a decreased risk of DNMT3A -CH (OR = 0.31, 95% CI = [0.18, 0.55], P = 1.44 × 10 −6 ; Fig. 4b and Supplementary Table 15 ).

In childhood blood samples, these differences in blood DNAm of MTNR1B CpGs were nominally significant ( p < 0.05) and retained the same positive direction, suggesting persistence of associations.

Of the nominally significant single‐cell SMR associations ( P <0.05), >75% (Figure 2E ) were not detected in the corresponding GTEx brain tissue SMR analyses.

A logistic distribution was assumed to represent zero inflation and further specification tests were conducted to assess correlates of this component of each analysis model; each covariate was tested separately and all covariates nominally significant (p < 0.05) were included in the inflation equation.

This effect was nominally significant (p < 0.05) for four of the eight fingers tested: left 2 nd finger, left 5 th finger, right 2 nd finger, and right 4 th finger ( Table 2 ).

Patients with LSM ≥16.9 kPa experienced a nominally significant reduction in mean ALP from 220 U/L (95% CI, 170‐285) at initiation to 211 U/L (95% CI, 157‐283) at 12 months ( P < 0.05) compared to patients with an LSM <16.9 kPa (n = 45), who demonstrated a 67‐U/L reduction in mean ALP from 288 U/L (95% CI, 249‐332) to 221 U/L (95% CI, 191‐256) over 12 months ( P < 0.01), although ALP at initiation was lower among those with advanced disease (Supporting Table S2 ).

So it should be kept in mind that each individual p value has a one-in-twenty chance of being nominally significant (p < 0.05) purely from random fluctuations.

Among 15 associations with more than two instrumental variables (9 metabolites, 7 FinnGen outcomes), seven associations (3 metabolites, 6 outcomes) remained nominally significant ( P -value < 0.05) in MRPRESSO outlier test.

To lessen the influence of differential statistical power among the three studies (n = 206, 60, 266), we defined ‘replication’ as having a nominally significant p-value in the independent sample (p-value<0.05) and having a concordant effect direction ( i.e. , is YFG more highly expressed in males or females?). 29.9% and 32.1% of genes significantly affected by sex (UC sex t-test FDR<5%) replicated in the UW and Merck studies, respectively ( Figure 1B ).

Since the primary endpoints in both trials did not reach statistical significance, all other p-values <0.05 for both predefined subgroups and post hoc analyses are considered nominally significant and hypothesis-generating.

However, the ADL scale had a nominally significant ( p ‐value <0.05) association with total cerebellar volume and cervical spinal cord CSA (Table S4 ).

Five of the 19 SNPs demonstrated a nominally significant association with neovascular AMD (P < 0.05), of which two (rs3173798 and rs3211883) withstood Bonferroni correction for multiple testing (rs3173798, nominal P = 9.96 × 10−4, allele-specific odds ratio = 0.55; rs3211883, nominal P = 2.09 × 10−4, allele-specific odds ratio = 0.50).

Epigenome-wide association study of Frailty Index Testing 723,029 lsBINs in 50 FI discordant MZ twin pairs (Gr1) implementing paired t tests revealed overall N D = 27,485 bins that showed nominally significant associations ( P < 0.05), and of these, the top 20 association signals were ranged P = 7.01 −5 to 2.17 −6 .

In the univariate radiomic analysis, 148 of 1,015 features were nominally significant ( p < 0.05), but none remained significant after Benjamini-Hochberg correction (smallest FDR-adjusted p = 0.30).

Step 5: We generate a ranked list of drug repositioning candidates and MOA categories that show enrichment of nominally significant ( p < 0.05) gene-based associations (MAGMA and S-PrediXcan) across compounds within each category.

Longitudinal assessment of circulating levels of 29 immune biomarkers revealed that mean levels of nine molecules (IL-1β, IL-1RA, IFN-γ, eotaxin, MCP1, MDC, MIF, RANTES, and HGF) showed changes across the experimental time points that were nominally significant (p < 0.05, Table 1 ).

To be included as a training feature in the outer loop, we required that a given functional connection exhibit at least one nominally significant behavioral correlation ( p < .05) across all folds of the inner loop.

As an exploratory study, we also indicated associations that are nominally significant with a P-value <0.05.

None of these were nominally significant in the full UKBB dataset ( p -value > 0.05).

Among complete blood count, red cell distribution width, PLT, and PCT showed nominally significant pre–post differences ( P < .05).

As a matter of fact, only 10% of SNPs from the Candidate Set 1 had nominally significant p -values < 0.05, while 42% of SNPs from Set 2 were nominally significant at the same α.

Larger magnitude nominally significant (p<0.05) genetic correlations were also found with depression-related phenotypes (range of r g 0.46–0.52), self-reported osteoarthritis ( r g = 0.63), and ICD-10-defined osteoarthritis ( r g = 0.49) phenotypes.