“nominally significant”

BNC2 rs10756819 was not genome-wide significant but showed a consistent and nominally significant effect in all studied cohorts ( p value <0.05); this therefore replicated our previous finding from a candidate gene study (Jacobs et al. 2012 ) suggesting that BNC2 influences subtle variation in skin color.

In total, we found 227 nominally significant ( P < 0.05) differentially expressed genes (DEGs) between the treated and control groups, with 23 DEGs significant after adjustment for multiple correction ( Fig. 2c , Table S2).

All the nominally significant genes ( P < .05) of differential expression with BMD in Chinese are summarized in Table 2 .

HMOX1 induction is nominally significant in HNSC (Wilcoxon p-value <0.05), and is not significant in UCEC or BLCA.

Regardless of the Bonferroni correction, the term “nominally significant” refers to genes with Fisher’s exact test P values ≤ 0.05.

Only the sociability and rs-fMRI trait pairs showing at least nominally significant ( p < 0.05) global, bivariate genetic correlations were further explored at the local genomic level.

To further explore these regions, we applied more relaxed criteria and detected two nominally significant eQTLs ( P < 0.05) in the NJMU lung eQTL database: MTAP at 9p21.3 and TCF7L2 at 10q25.2 (Additional file 2: Fig.

In the primary MR analysis, 24 lipid metabolites showed nominally significant associations ( p < 0.05) with the risk of ER+ breast cancer ( Table S3 , Figure 2(a) ), while 23 metabolites were similarly associated with ER− breast cancer ( Table S4 , Figure 2(b) ).

Using TDT, we identified eight nominally significant associated SNPs ( p =<0.05).

Additional post hoc analyses show that these SNVs remain suggestively significant ( p < 5 × 10 −5 ) when not covarying for APOE and the HRs remain in the same direction and nominally significant ( p < 0.05) when using models that include APOE ε2 and ε4 separately in dominant and additive models (Table S4 in supporting information). 3.2.2 APOE analyses Next, in Cox proportional hazard (PH) models, carriers of ε2/ε4, ε3/ε4, ε4/ε4 had an elevated HR (Cox PH HR > 1) for earlier conversion to amyloid positivity compared to ε3/ε3 homozygotes. ε2/ε3 carriers demonstrated a lower risk ratio (Cox PH HR < 1; Table 3 ).

We observed a nominally significant (p<0.05) gene–gene interaction between the SEC14L2/TAP and SLC23A2 polymorphisms in determining POAG risk, increasing POAG risk in those subjects who had both risk genotypes at the same time (p<0.01).

These loci remained at least nominally significant (p < 0.05) in all five iterations (online Supporting Information Table S14 ).

The nominally significant p -value was defined as 0.006 ≤ p < 0.050, indicating suggestive evidence for potential causality.

A significant association was determined if (1) the p -value for the cross-trait meta-analysis reached genome-wide significance ( p < 5 × 10 −8 ) and (2) the univariate GWAS effects were at least nominally significant ( p < 0.05).

Of the 246 main meta-analyses, 56 variants within 45 different genes showed nominally significant genetic associations with lung cancer ( p -value < 0.05) (Table 1 , Supplementary Table S2 ).

Index SNPs in 19 of the 21 loci exhibited interactions with alcohol as evidenced by either a suggestive 1 df interaction test or a significant/suggestive joint 2 df test in conjunction with a nominally significant ( p < 0.05) 1 df interaction test; two PP loci (represented by rs4953404 and rs12292796) appeared to be driven by main effects only (1 df interaction tests have p -values > 0.3 as shown in Table 3 ) and will be excluded from further discussion (see Figures S8 – S14 for the regional association plots for all the significant and suggestive loci).

Mendelian randomization analysis For sex hormones, the MR IVW estimates for total T [-0.09 (-0.16, -0.01)] in men and bioavailable T [0.13 (0.03, 0.23)] in women were nominally significant ( p <0.05), but they did not pass the significance level of p < 0.0071 after Bonferroni correction.

Nominally significant associations ( p < 0.05) were observed between higher maternal levels of IL-8 during early pregnancy with lower gross motor (β: −0.902, 95%CI: −1.697, −0.107, p = 0.026) and fine motor (β: −0.880, 95%CI: −1.500, −0.259, p = 0.006) skills score at age one.

Moreover, a nominally significant association threshold ( p < .05) was set in the replication stage to ensure that the overall significant association is robust across populations.

Three previously reported sites mapping into the genes MCM2 , EXOC3 , and JARID2 were significantly associated with one or more traits after correction for multiple testing ( P < 1.6e-03, Supplementary Data 12 ), and another seven showed nominally significant associations ( P < 0.05).

All discovery SNP-CpG associations ( n = 497,689) were nominally significant at baseline ( P < 0.05), and 99.5% ( n = 497,443) were nominally significant during the course of the disease ( P < 0.05).

Of the 279 gene–trait associations for which we attempted replication, 193 (69%; 28 with a binary trait, 165 with a quantitative trait) were nominally significant ( P ≤ 0.05) and directionally consistent (Supplementary Table 6 ), versus around 7 expected by chance (279 × 0.05 × 0.5).

Through Model 1, there was a tendency towards a positive association between birth weight PGS and plasma levels of 5 proteins FABP2 (fatty acid-binding protein, intestinal), LPL, TNF (tumour necrosis factor), TNFB (TNF beta), GIF (gastric intrinsic factor) and a negative association with 3 proteins PRSS8 (prostasin), KIM1 (hepatitis A virus cellular receptor 1), and AMBP (protein AMBP), which were nominally significant ( P < 0.05) ( Fig. 3 b; Supplementary Table S10 ).

Nominally significant differences (uncorrected p < 0.05) were observed at Cz, T4, and O2 electrodes in a narrow time range between 449 and 487 ms; however, we observed more positive values in CTLs, compared to NMS, whereas the opposite pattern was observed in the original study ( Fig. 1 /C ). 3.3 HEP during REM in nightmare and control participants: Study 2 The comparison of HEP during REM sleep did not yield significant differences across NMs and CTLs in Study 2 ( Fig. 1 /B ).

Those genes that yielded at least nominally significant interaction terms (raw p < 0.05 ) and FDR-significant associations within male or female strata were determined to have sex-specific associations with Cd.