“nominally significant”

These loci remained at least nominally significant (p < 0.05) in all five iterations (online Supporting Information Table S14 ).

Mendelian randomization analysis For sex hormones, the MR IVW estimates for total T [-0.09 (-0.16, -0.01)] in men and bioavailable T [0.13 (0.03, 0.23)] in women were nominally significant ( p <0.05), but they did not pass the significance level of p < 0.0071 after Bonferroni correction.

In the primary MR analysis, 24 lipid metabolites showed nominally significant associations ( p < 0.05) with the risk of ER+ breast cancer ( Table S3 , Figure 2(a) ), while 23 metabolites were similarly associated with ER− breast cancer ( Table S4 , Figure 2(b) ).

Additional post hoc analyses show that these SNVs remain suggestively significant ( p < 5 × 10 −5 ) when not covarying for APOE and the HRs remain in the same direction and nominally significant ( p < 0.05) when using models that include APOE ε2 and ε4 separately in dominant and additive models (Table S4 in supporting information). 3.2.2 APOE analyses Next, in Cox proportional hazard (PH) models, carriers of ε2/ε4, ε3/ε4, ε4/ε4 had an elevated HR (Cox PH HR > 1) for earlier conversion to amyloid positivity compared to ε3/ε3 homozygotes. ε2/ε3 carriers demonstrated a lower risk ratio (Cox PH HR < 1; Table 3 ).

To further explore these regions, we applied more relaxed criteria and detected two nominally significant eQTLs ( P < 0.05) in the NJMU lung eQTL database: MTAP at 9p21.3 and TCF7L2 at 10q25.2 (Additional file 2: Fig.

Despite limited overlap at the single-metabolite level between the two overall OC outcomes, we observed greater concordance at the pathway level: among nominally significant pathways (raw p < 0.05), arginine and proline metabolism and beta-alanine metabolism overlapped across the two outcomes ( Figure 1 E; Supplementary Table S4 ).

Index SNPs in 19 of the 21 loci exhibited interactions with alcohol as evidenced by either a suggestive 1 df interaction test or a significant/suggestive joint 2 df test in conjunction with a nominally significant ( p < 0.05) 1 df interaction test; two PP loci (represented by rs4953404 and rs12292796) appeared to be driven by main effects only (1 df interaction tests have p -values > 0.3 as shown in Table 3 ) and will be excluded from further discussion (see Figures S8 – S14 for the regional association plots for all the significant and suggestive loci).

All discovery SNP-CpG associations ( n = 497,689) were nominally significant at baseline ( P < 0.05), and 99.5% ( n = 497,443) were nominally significant during the course of the disease ( P < 0.05).

In total, 67 associations were identified to be associated with IBD at the nominally significant level (P < 0.05) ( Table S8 ).

Moreover, a nominally significant association threshold ( p < .05) was set in the replication stage to ensure that the overall significant association is robust across populations.

Three previously reported sites mapping into the genes MCM2 , EXOC3 , and JARID2 were significantly associated with one or more traits after correction for multiple testing ( P < 1.6e-03, Supplementary Data 12 ), and another seven showed nominally significant associations ( P < 0.05).

Those genes that yielded at least nominally significant interaction terms (raw p < 0.05 ) and FDR-significant associations within male or female strata were determined to have sex-specific associations with Cd.

Nominally significant associations ( p < 0.05) were observed between higher maternal levels of IL-8 during early pregnancy with lower gross motor (β: −0.902, 95%CI: −1.697, −0.107, p = 0.026) and fine motor (β: −0.880, 95%CI: −1.500, −0.259, p = 0.006) skills score at age one.

Regardless of the Bonferroni correction, the term “nominally significant” refers to genes with Fisher’s exact test P values ≤ 0.05.

Pathway analysis for candidate genes arising from the family‐based association analysis with nominally significant association ( p ‐value < 0.05).

It is worth noting that for MD phenotypes and childhood body fatness, the associations with V remained nominally significant ( P < 0.05) if we further adjust for BMI and PD in the SNP-set test.

However, there are over 200 nominally significant between-breed genetic correlations but less than 50 phenotypic correlations compared with an expected error of 20 at p < 0.05.

3.4 Multivariate regression to maximize the association with subjective cognitive decline scores All variables which were nominally significant (p < 0.05) in the competitive model analysis, in addition to covariates, were then selected as input variables in a backwards stepwise multiple regression analysis to maximize the R adj 2 value ( Fig. 3 A ).

Given the known prior association with AAA, we used a nominally significant P <0.05 to declare significance.

Of the 279 gene–trait associations for which we attempted replication, 193 (69%; 28 with a binary trait, 165 with a quantitative trait) were nominally significant ( P ≤ 0.05) and directionally consistent (Supplementary Table 6 ), versus around 7 expected by chance (279 × 0.05 × 0.5).

In unadjusted analyses, 26 SNPs from nine loci were associated with TC, 22 SNPs from 10 loci with LDL, 58 SNPs from 13 loci with HDL, and 40 SNPs from 14 loci with logTG at the nominally significant level ( P < 0.05).

Separately, an excess significance test was conducted using the χ 2 test to investigate whether the observed number of studies with nominally significant results (O;”positive” studies, P < 0.05) differed from the expected number of significant results (E).

Survival analysis incorporating low KDM5D as a prognostic indicator yielded nominally significant P -values ( P ≤ 0.05) in seven cancers types, most significantly in head-neck squamous cell carcinoma (n 366, HR 1.79 [95% CI 1.3, 2.5], P = 0.0003) and liver hepatocellular carcinoma (n 249, HR 1.85 [95% CI 1.16, 2.94], P = 0.008).

Many of our networks had nominally significant (p < 0.05) overlaps with the cell-type-specific DEGs in neuronal cell types, which include both upper and deep layer excitatory neurons and inhibitory interneurons ( Figure 3 C and Table S12 ).

There were 26602 nominally significant ( P -value < 0.05) CpG sites ( Figure 1 ).