We found that 12 of these genes were significantly upregulated (fold-change >15%, FDR < 0.05) following chronic DBS in the Het samples ( Figure 6C ; genes with a significant increase in expression are indicated by asterisks) and that many of the other genes showed a trend toward increased expression following chronic DBS.
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Additionally, a direct correlation was also found between expression of DRD5 and the Knosp score, which also showed a trend to associate with the expression of sst3 (Fig. 4D ).
The mice that received the APS1 intervention also showed a trend of increasing expression of PGC1 and decreasing expression of FAS and FABP4 in liver tissue.
Specifically, from the acute stage to the early chronic stage, the temporal variability in the ipsilesional PreCG and the contralesional hippocampus was increased first and then decreased, while the temporal variability of the other regions showed a trend of gradual increase.
We assessed the following features for associations with an increased risk of fracture: female gender, HCV co-infection, and previous corticosteroid use showed a trend toward association with an increased risk of vertebral fracture, but this association was not statistically significant.
As shown in Figure S8 , ACE CD19.CAR-T cells showed a trend for a lower frequency of Annexin V + cells within the CAR + T cells as compared to CD19.CAR-T cells stimulated with anti-CD3/CD28 mAbs.
All Teff subsets still showed a trend of reducing peak parasitemia within 14 days, though this was only significant for Teff Int ( S2E Fig ).
Conversely, 4,313 of 4,986 regions (86.5%) of the genome that lost DNA methylation in early-passage Dnmt3a KO HSCs (hypo-DMRs) showed a trend toward continued loss of methylation in later stage transplant Dnmt3a KO HSCs.
Some of the inflammatory mediators that were found elevated in the lungs of tumor-free Ikkβ Δmye animals (Figure 4A ) also showed a trend towards slightly increased expression in the mammary glands of tumor-free Ikkβ Δmye animals and Il1b expression was significantly higher ( Supplementary Figure 2 ).
As the experiments showed a trend for different fluid behaviour at the beginning phases of the experiments (electronic supplementary material, S2 and figure S2), it was decided to also compare the mean velocities between the first five seconds of a measurement and the mean velocities (again of five seconds) after one-third of the experiment had passed.
Results : Although NOD.Zbtb32 -/- male NOD mice showed a trend towards increased diabetes incidence compared to littermate controls, the difference was not significant.
The GPC again showed a trend of increasing with ⟨ V bias ⟩, but at a slower rate than the 10 s bias condition reaching a comparatively lower value at −254 V ( Figure 3 a).
The rough morphotype neutrophil medium showed a trend toward more effective killing of both individual morphotypes ( Fig 8E and 8F ).
7 a, b), LC3B-II levels showed a trend to increase in presence of leupeptin, which, however, did not reach statistical significance, when compared to control (Fig. 7 a, c).
AS6 showed a trend toward being impactful, but it did not meet the threshold for statistical significance.
However, analysis of the solanezumab data in people with mild AD showed a trend toward improved cognition moving the field of immunotherapy in AD from established AD towards the prodromal or mild AD with the aim to halt the cognitive decline as early as possible.
We found that ICT followed by 5-fluorouracil (5FU)-based CCRT showed a trend of better survival compared to chemotherapy alone.
The mean power of ictal and synchronized interictal-like activity showed a trend to decrease from 14 DIV in the treated slices; however, the difference was not significant (Fig. 7 D).
The adjusted mean HDL levels in patients with a combination of periodontitis (−) and bacterial burden (low, moderate, and high) and periodontitis (+) with the presence of bacterial species (low, moderate, and high) were decreased ( p for trend < 0.5), while TG levels in those groups showed a trend to increase ( p for trend < 0.5) as shown in Fig. 3 .
Moreover, the eligible population showed a trend to be younger than 50 years and to have fewer ductal carcinomas.
Although none of the biomarkers tested predicted response to sorafenib, patients with high s-c-KIT or low baseline hepatocyte growth factor concentration in the sorafenib cohort showed a trend towards enhanced benefit. 69 , 70 The ALICE-1 study looked at VEGF and VEGFR genotyping to predict outcomes with sorafenib and identified several polymorphisms (single nucleotide polymorphism [SNPs]) of VEGF that influenced PFS and OS. 71 The ALICE-2 study also showed SNPs of hypoxia-inducible factor-1α (HIF-1α) to be significant for PFS and OS.
Subgroup analyses showed a trend toward a significant reduction in SSB intake in participants in school-based interventions compared with control groups.
When compared to control, low concentration treatment (PS-NP-10) tends to gradually increase MBC with significant increase at day 28. Basal respiration and metabolic quotient (qCO 2 ) showed a trend of increase with increasing PS-NP application compared to control (Fig. 2 B).
Although we did not detect significant associations, the results showed a trend toward reduced mean BMI in heterozygous overweight/obese children than in homozygous wild type.
Finally, sense of agency showed a trend toward a negative correlation with the strength of the illusion as subjectively perceived by participants with PTSD and PTSD+DS.