Barely Significant
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“showed a trend”

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At this timepoint, there was no statistically significant increase in TGF‐β1 or TGF‐β2 in the fractionated treatment F‐sEVs group relative to the Vehicle group (Figure 4 g, h ), although TGF‐β levels showed a trend towards an increase at this time.
Results of GSEA are as follows: monogenic obesity genes were significantly enriched in the arcuate nucleus of the hypothalamus and showed a trend of enrichment in the embryonic hypothalamus ( Supplemental Figure 6, A and B ); rare coding variants were significantly enriched in embryonic hypothalamus and hindbrain ( Supplemental Figure 6, A and C ); low-frequency coding variants were enriched in hypothalamic regions, significantly in the dors