We were surprised to find that after 8 hours of insulin deprivation, plasma ammonia levels (measured by LC-MS/MS) showed a trend (p = 0.088) toward lower levels in insulin-deprived vs. treated T1D, even though these patients exhibited greater urinary nitrogen loss over the first 6 hours of insulin deprivation [13] .
The observed changes in cytokine levels and the IFN-γ/IL-5 ratio from baseline after treatment with the highest dose (10 μM) of DHEA were significant in all comparisons, except for changes in the IFN-γ/IL-5 ratio in men with AHR, which showed a trend toward increasing ( p =0.088) ( Table 2 ).
In survival analyses, patients in the upper quartile of FGR expression showed a trend toward inferior OS compared with the remainder of the cohort (HR = 1.34, 95% CI 0.96-1.87; P = 0.088), while no association was observed for PFS (HR = 1.12, 95% CI 0.80-1.57; P = 0.510) ( Supplementary Figure 1 ). 3.3.
In contrast, IA treatment with HYADD®4-G showed a trend towards increased quantity of total HA ( P = 0.088, not significant) and a significantly increased HMW-HA ( P = 0.042) synthesis by the ovine synovial cells when compared with cells from the joints of saline-treated sheep.
Furthermore, dietary 200 mg/kg puerarin showed a trend toward increased CAT activity in the serum ( P = 0.088) and liver ( P = 0.085).
1 c), while alpha-bisabolol at 100 μg (s.c.) showed a trend towards reducing scratching time ( p = 0.0882), but without reaching statistical significance (Fig. 1 d).
Intriguingly, the treatment showed a trend to decrease cells viability when compared to vehicle ( p ‐value = 0.0884) and ZIF‐8 0.01 mg mL −1 ( p ‐value = 0.0710), whereas a significant decrease was observed when compared to lidocaine 0.01 mg mL −1 (Figure 6b ).
Stimulation with rmCIRP increased the protein expression of IL-1β in WT pulmonary fibroblasts by 2.5 fold, which showed a trend towards statistical significance (p=0.0884, Figure 1F ).
Pearson’s coefficient analysis in the present study revealed that tearing sensation was not associated with a history of systemic allergy ( p = 0.1653) but showed a trend toward an association with conjunctival papillae ( p = 0.0887).
A further exploratory analysis revealed that non-responders compared with responders showed a trend towards a higher ECOG status ≥1 ( p = 0.0887), albeit not significant, and no differences between non-responders and responders in baseline LDH ( p = 0.6646) and S100 levels ( p = 0.7500) were observed.
Post hoc testing showed a trend toward a decreased microvascular perfusion index at 2 hours hemodialysis compared with baseline in the control group ( P = 0.0889, Figure 4 ).
High VPI showed a trend towards being associated with distant metastasis as first site of recurrence (OR 2.4; 95% CI 0.90–5.59; p = 0.089), compared to recurrence at a local or regional site.
While pre-procedural INR > 1.5 showed a trend towards increased risk (OR 2.78), it did not reach statistical significance in this model ( p = 0.089).
PLAUR and SERPINB2 both showed a trend toward upregulation in SARIFA-positive CRCs ( PLAUR : adjusted p value = 0.089, SERPINB2 : adjusted p value = 0.11).
Similarly, lobar CMBs showed a trend toward increased odds in men with AF in the unadjusted model (OR = 2.4, 95% CI: 0.9–6.3, p = 0.089), but this association was weakened and lost statistical significance in adjusted models (Model 4: OR = 1.2, 95% CI: 0.3–4.2, p = 0.759).
In contrast, SLC27A1 expression was positively correlated with serum creatinine (Pearson r = 0.467, P = 0.038; Figure 10c ) and showed a trend toward correlation with blood urea nitrogen (Pearson r = 0.390, P = 0.089), while no significant association was found with 24-hour proteinuria ( P > 0.05).
The smaller dataset showed a trend of a correlation between F-actin and CADM1 (P = 0.089, Fig.
Age was not a significant predictor (OR = 0.98 per year, p = 0.612), and income ≥ 10,001 SAR showed a trend toward increased access (OR = 1.28, p = 0.089) but did not reach conventional significance.
As predicted, PQ/PTS rats showed a trend toward significance, F (2, 33) = 2.60, p = 0.089, η 2 = 0.136.
Functional outcomes at discharge showed a trend toward better recovery in the FD group than the SAC group (mRS 1.9 vs. 2.9, p = 0.089).
26 months, p = 0.009) resulted in significant differences (Figure 2 ), while pHH3 index ≤0.8 versus >0.8 showed a trend (p = 0.089).
Results: Younger age and higher disease severity showed a trend toward reduced microbial diversity (β = 0.066, p = 0.089, and β = −0.054, p = 0.089).
The ESB group showed a trend ( p = 0.089) toward reduced CRP compared to the ESPB and CB groups at the endpoint.
Among patients who had a KIT exon 11 mutation (n=40), the 5-year group still showed a trend toward a better RFS (p=0.089; 4-year RFS, 83.3% vs. 61.5%, respectively) ( S3 Fig. ).
Weight‐adjusted AAD/6W increased with increasing ERI for roxadustat (ERI <3.3, 0.89 mg/kg; ERI ≥8.4, 1.51 mg/kg) and DA (ERI <3.3, 0.26 μg/kg; ERI ≥8.4, 0.91 μg/kg); the weight‐adjusted AAD/6W relative to within‐arm mean AAD/6W showed a trend toward increased DA doses for the ERI ≥8.4 category ( P = .089).