Barely Significant
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“showed a trend”

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In the literature

Patients with a larger tumor burden—defined as a primary tumor size ≥ 2.5 cm, the presence of multiple pancreatic tumors, or tumor metastases—showed a trend toward higher serum LEAP2 levels compared with those with a lower tumor burden (median 30.9 ng/mL, range 2.02-79.1 ng/mL vs . 20.2 ng/mL, range 14.28-70.66 ng/mL; P = 0.118; Supplementary Figure 6 ).
Although Asian studies showed a trend toward greater improvement in imaging outcomes, this difference did not reach statistical significance when formally tested for interaction ( p for interaction = 0.9201 for MACE and 0.0581 for LLL), suggesting that the overall treatment effect of DCB was largely consistent across populations despite baseline risk factor disparities.