Barely Significant
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“showed a trend”

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In the literature

Importantly, the only notable change in this RCT-only analysis was observed for minor bleeding events (BARC type 1).Whereas de-escalation was associated with a significantly lower risk of BARC 1 bleeding in the overall analysis (previously RR: 0.52, 95% CI: 0.32–0.86), the RCT-restricted analysis still showed a trend toward reduced minor bleeding with de-escalation but this difference was no longer statistically significant (RR: 0.65, 95% CI: 0.28–1.50, p = 0.311).This attenuation of significance is most likely due to the reduced sample size and statistical power after excluding the observational cohorts, rather than a true reversal of effect.Overall, the RCT-only sensitivity analysis confirms the robustness of our primary findings.
Using SubtlePET® software showed a trend toward improvement, with a reduction in background variability for images acquired with 75% and 50% of the normal acquisition time processed by AI, compared to standard reconstructions.