The X‐based group also showed a trend toward improved OS compared to the other mCHT group, although this was not statistically significant ( p = 0.136, Figure 4C ).
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Although no statistically significant differences were observed in dose to organs at risk (OARs) or NTCP, higher‐frequency schedules showed a trend toward reduced variability.
Notably, compared with the model group, the intestinal microbiota structure of the OEH group showed a trend towards convergence with that of the control group.
Our beta diversity analysis showed a trend towards statistical significance, demonstrating that CC/UWL-AHF status explained ~1.6% of the variance in microbiome structure when compared to patients without ( p = 0.071).
Quantitative analysis of CoQ partitioning demonstrated that inhibition of the SCAP–SREBP pathway led to a significant decrease in non-mitochondrial CoQ, while the levels of mitochondrial CoQ showed a trend toward an increase ( Fig. 3, j and k ).
Notably, unlike the VAE, the MCVAE showed a trend toward enrichment ( , one-sided hypergeometric test) of FMRP targets in the mouse-only consensus set and the combined mouse–human dataset (Fig. 4B and Supplementary Table S6 ).
The presence of cirrhosis showed a trend toward increased risk but did not reach statistical significance in the adjusted model (adjusted OR = 2.82, 95% CI 0.99–8.05; P = 0.053).
Patients with DANE had higher risk of DTA growth ≥5 mm/y (odds ratio, 5.78 [1.58-24.0]) and showed a trend toward more reinterventions within 6 or 12 months (odds ratio, 4.62 [0.91-34.9] and 3.69 [0.85-19.8]; Figure 3 ).
In in vivo experiment, A485 showed a trend toward inhibiting BBN-induced bladder cancer invasion in mice.
[ 13 ] NHANES data analysis also showed a trend association between BPA and adult high-frequency hearing loss, but existing evidence is mostly limited to epidemiological relevance and lacks in-depth exploration of causal mechanisms.
Finally, consistent with other studies, 28 , 29 Asian and Native American patients showed a trend toward lower rates of morphine administration, although small sample sizes limit definitive conclusions.
Overall image quality showed a trend toward improvement with DL-denoising; conversely, DL-denoising was associated with a modest increase in perceived aliasing severity across most acquisition protocols; however, after correction for multiple comparisons, none of these differences reached statistical significance (Holm-corrected p>0.05 for all protocols).
Nevertheless, Widening a ER groups showed a trend toward a worse functional outcome.
In a clinical trial involving patients with SLE, metformin showed a trend toward reducing disease relapse, however, the difference relative to placebo was not statistically significant ( 73 ).
At the experimental endpoint, ex vivo BLI analysis of lung tissues showed a trend toward reduced metastatic seeding in TRMT112 KD mice (Fig. 7 G, H).
lactis V9 combined with αPD-1 therapy showed a trend of slowing tumor growth in both tumor models, suggesting that it may enhance the anti-tumor effects of immune checkpoint inhibitors.
Neoadjuvant therapy showed a trend toward increased LARS but did not reach statistical significance ( p = 0.30) (Table 6 ).
When comparing the two models, although Polg mut/mut mice showed a trend toward a more pronounced reduction in CSA than Mito-mice∆, the difference did not reach statistical significance (Fig. 2 F).
Clusters 3 and 4 showed a trend towards lower prevalence, possibly due to a higher incidence of coma and persistent coma, limiting delirium assessment.
Patients with positive PD-L1 expression (CPS ≥ 1) showed a trend toward better clinical outcomes than PD-L1 negativity, as evidenced by a higher ORR (64.5% vs. 40.0%) and longer median PFS (10.4 months vs. 4.0 months) as assessed by IRC, as well as improved survival (median OS: 15.4 months vs. 13.3 months; 12-month OS rate: 61.3% vs. 50.0%) (Table 4 ).
Overall, the combination of acupuncture stimulation therapy with standard treatment showed a trend toward positive improvement to varying degrees across all outcome measures.
As a result, infusion rates showed a trend toward lower values in the old age group compared to the young age group, although the between-group difference was not statistically significant.
In our cohort, peroneal CMAP amplitudes showed a trend toward negative correlation with NfL that did not remain significant after age adjustment.
The inflammatory markers IL6, IL8, and IL1β showed a trend of upregulation in the cytokine group and downregulation in the enzyme group, while the combination group remained close to the control (Figure 6e ).
Although hopelessness showed a trend toward improvement, this change was not statistically significant.