Barely Significant
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“showed a trend”

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Finally, within a limited sample size with both fecal butyrate and weight outcome data available ( n = 623), butyrate showed a trend to mediate the association between maternal prenatal smoking and certain childhood weight outcomes (proportion mediated in unadjusted models: year-1 BMI z-scores, 6.7%, p = .066; year-3 AROW or OWOB, 6.4%, p = .054; proportion mediated in adjusted models: year-1 BMI z-scores, 6.4%, p = .182; year-3 AROW or OWOB, 5.1%, p = .198).
14 , 15 , 49 , 74 Interestingly, one candidate modifier that showed a trend of association 66 , 75 and was replicated by GWAS is TCERG1, which harbours a complex coding hexamer repeat that appears to be the source of the influence on HD age-at-onset. 76 Unfortunately, the hexamer repeat with potential association was not imputed in our data because this repeat was not present in the imputation reference panel that we used.