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“showed a trend”

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Indeed, although a phase II trial investigating carboplatin, paclitaxel, and vorinostat in advanced NSCLC patients showed a trend toward improved ORR with the addition of vorinostat ( NCT 00481078 ) [ 21 ], the subsequent phase III trial in the same population failed to meet the primary endpoint of overall survival (OS) in a pre-specified interim analysis, revealing a negative impact of vorinostat on clinical outcomes ( NCT00473889 ) [ 22 ].
The results of this comparison showed that the patients with worse CAT but better ACT scores (n = 28, 71.8% of discordant) had significantly higher body mass indexes (BMIs), lower COTE comorbidity indexes and better FEV1/FVC ratios and also showed a trend towards younger age and better FEV1 scores (mL) compared with those with good CAT but poor ACT scores ( Table 5 ). 4.
We measured the MDA content and CAT, SOD and GPx activities in the intestinal contents of the larval midgut tissue, and found that the MDA content showed a trend of decreasing–increasing–decreasing, which decreased at 6 h and 24 h after infection, respectively, and was significantly different from that at Bt 0h, but the MDA content at Bt 6h, Bt 12h and Bt 24h was lower than that at Bt 0h.
However, the placebo effect has not been studied in vaginismus, 23 and a meta-analysis of a few randomized controlled trials showed a trend toward higher efficacy of active treatment versus controls in vaginismus. 24 Conclusion Intravaginal BoNTA injection is a safe and effective treatment option in patients with vaginismus who have failed conventional therapies.
Similarly, Suox showed a trend towards lower levels in female animals (Figure 2d , FDR <0.1). 6.4 NAD + biosynthesis‐related genes Among the genes associated with NAD + biosynthesis, 4 of them showed differential expression (Figure 2e–h ).
Weight Our pooled studies at endpoints showed a trend towards higher weight with lifestyle interventions plus metformin; however, this did not reach statistical significance (SMD = 0.12, 95% CI [-0.03, 0.27], P = 0.11).