Excerpts

This difference was highly significant and the methylation status was able to predict the presence of cancer.

Radiomic features can also identify distinct GBM phenotypes associated with highly significant survival differences and specific molecular pathways [ 36 ].

A lower expression of the MLH1 gene, which is also located on chromosome 3p, was significantly related to prognosis in one cohort and showed a near-significant effect in the other cohorts.

Despite this considerable variation between strains, as an overall trend we detected stronger EPIYA-C signal intensities compared to the other two variants, independent of their phosphorylation state.

However, this observation seems time dependent, because at 20 weeks there was a strong trend towards more WT mice with moderate inflammation throughout the colon compared to Gsdme KO mice, while at timepoint 22 weeks and 24 weeks there was an inverse trend towards more Gsdme KO mice with moderate inflammation compared to WT mice.

If we look specifically at inflammation associated with adenocarcinomas, we were able to find a clear trend showing a more severe grade of mononuclear cell infiltration in the Gsdme WT adenocarcinomas when compared to the Gsdme KO adenocarcinomas in the chemical experiment.

Moreover, nuclear-specific localization of the ARV7 protein within the CTCs might be significant in terms of guiding treatment selection in mCRPC patients [ 20 , 21 ].

Slightly significant reduction in pure-tone average (PTA) and in the speech discrimination score (SDS) was measured, which, however, were functionally not relevant ( Table 1 ).

We have recently identified SF3B1 on chromosome 2 as a Copy-number alterations Yielding Cancer Liabilities Owing to Partial losS (CYCLOPS) gene with a highly significant positive correlation to hypoxia-inducible factor-1α (HIF1α) [ 26 ].

Although a slight increase of marginal significance in the total number of tumor GFP + cells was detected for co-cultures with TGF-β treated NIH3T3 in the microscale platform ( Figure 4 A.2), the overall effect on tumor growth was of similar magnitude regardless of the culture modality for both WT and TGF-β co-cultures.

In contrast, CRT ( n = 241) seemed to provide only a slight trend towards an OS advantage in R1-resected pts, emerging as a positive difference in median values of 3.5 months, as well as non-significant HR of 0.72 and 2-y and 5-y rates (30% vs. 19% with observation, and 18% vs. 8%, respectively).

In addition, an increasing trend was present between doxorubicin intensity and injected dose similar to that observed in the whole tumor slices ( Figure 3 B).

Based on high (H) or low (L) BAP1 gene expression levels, we investigated the survival difference within these two groups and found that in LGG, HNSC and PRAD, the survival difference between BAP1 high- and low- expression patients was slightly significant (–log­ 10 ( p -value) >1.2) ( Figure 4 A, B).

Regarding apoptosis (caspase-dependent PCDI) we were able to demonstrate a clear dose-dependent increase in CaSki cells following treatment with CX-5461, which was also apparent at highly significant levels following combinations of drug and X-rays.

While this narrowly missed statistical significance, it is a striking observation that should be further explored in a larger cohort.

Somewhat encouragingly, the extended survival times of animals, that tolerated the combination treatment in vivo, approached significance when compared with vehicle cohort.

The knockdown of Rab9 suppressed Zta expression in HA cells ( p = 0.0448) at a barely significant level ( Figure 2 d).

The results show a highly significant and positive correlation between MAGI2-AS3 and the four mRNAs.

In addition, PARP-1 cleavage fraction, which thought to be a marker of apoptosis, also showed an increasing trend with a higher concentration of TFP treatment and rescued by the pan-caspases inhibitor Z-VAD-FMK ( Figure 1 E).

In pancreatic cancer, systemic levels of IL-1β and IL-6 showed a trend towards the development of future thrombosis [ 44 ].

Indeed, in our review of the literature we found a robust association between proliferation, assayed by Ki-67, and presence of invasiveness with 62% of revised reports suggesting a positive correlation [ 145 , 146 , 147 ] and 38% indicating an unclear association, albeit with a positive trend [ 13 , 148 , 149 ].

NIPS using S1 plus palitaxel or docetaxel showed a trend toward improvement in overall survival [ 24 , 25 , 26 ].

IHC analysis of AM404 treated explants showed a trend of decreasing cell proliferation and stemness with increasing differentiation marker ( Figure 4 ).

All statistical tests were two-sided, and p values ≤ 0.05 and ≤ 0.01 were considered to be significant and highly significant, respectively.

Kaplan–Meier survival analysis revealed a highly significant association between the tumor content of IF1 and disease free survival (DFS) of the patients ( Figure 1 C).