Excerpts

Highly significant expression changes in 17 known cancer genes such as ERBB2, KRAS and SMAD4 were observed by analyzing the RNA sequencing data of 116 EACs, showing a correlation with a high degree of chromosomal instability [ 13 ].

In advanced NSCLC patients, neither the tumor stage nor the grading were able to accurately identify cases at higher risk of early disease recurrence, although a slight trend toward statistical significance was obtained when grouping according to the tumor stage ( Supplementary Table S4 ).

Combined therapy with crizotinib+decitabine or crizotinib+trametinib resulted in a significantly higher inhibition of tumor growth compared to single treatments, while tumors treated with crizotinib+CHO showed a trend toward better inhibition compared to single drugs ( Figure 3 E). 3.4.

While many of the inflammatory cytokines assayed did not exhibit statistically significant differences, there was a notable trend for cytokine levels to be higher in the plasma of immunized mice.

Given the highly significant correlation between SLFN11 mRNA expression and SLFN11 protein expression [ 118 , 119 , 121 , 128 ], RNA sequencing of patient tumor cells can be readily applied to determine the levels of SLFN11 expression.

Macrophages express hormone receptors [ 13 ] and because of the systemic nature of these metabolic hormones and the significant role that macrophages play in tumour development, the potential of dysregulated hormone levels to modulate tumour microenvironments and hence macrophage inflammatory responses may be significant. 2.

In their single institution retrospective study, they showed a favorable trend for neoadjuvant chemotherapy (versus a surgery-first approach) among patients of 75 years old and over.

Female CCSs who had received alkylating agents showed a decreasing trend in AMH levels.

A p -value of > 0.05 but lower of < 0.10 was considered of marginal significance.

Increased tumor size ( p = 0.01), presence of metastasis ( p < 0.001), presence of epithelioid cell morphology ( p = 0.008), involvement of iris ( p = 0.02), ciliary body involvement ( p = 0.02), absence of intrascleral location ( p = 0.02) and presence of extrascleral location ( p = 0.09) adversely affected OS, the latter association of borderline significance.

Furthermore, in the study of 24 CC patients, ctDNA variant allele frequency values at baseline showed a trend for a shorter PFS but this correlation was significant when focusing on the IHCC group [ 92 ].

This large-scale nationwide population-based cohort study revealed an increasing trend of the risk of all hematologic malignancies and NHL according to the progression of the glycemic status toward diabetes with a longer disease duration, without a significant interaction with obesity.

In EAC, a strong trend of earlier recurrence could be observed in the high S-DKK1 group with a median of 13 months (95% CI 6.96–19.04 ± S.E. 3.08) compared to patients with low S-DKK1 with a median of 17 months (95% CI 9.95–24.05 ± S.E. 3.60) ( p = 0.064) ( Figure 3 A).

The microcalcifications content for healthy MRT-treated samples show an increasing trend with the peak dose ( Figure 7 a), but no visible trend for their crystalline domain values or XRF Fe intensity signal is retrievable.

Visual disorder scores showed a trend to improve over time, although this was not significant.

Although its mortality rate is on a decreasing trend, prognostication and treatment selection is complicated, largely due to its high genetic and morphological heterogeneity [ 2 ].

76.8%) and reported a strong trend towards longer OS (HR 0.72; 95% CI 0.51–1.02).

In all patients, baseline BCL2 (unfavorable), baseline and Cycle 2 CD8/CNT (favorable), Cycle 2 CD8/INV (favorable; limited sample size), and increases in either CD8/CNT or CD8/INV (favorable; limited sample size) all had significant or nearly significant impacts on pCR.

The shRNAs #1 and #2 against ZRF1 showed an increase in the percentage of cells in the G1 phase, whereas shRNA #3 showed a trend towards G2/M arrest ( Figure 5 d).

Consistently, differential gene expression among TCGA showed a trend for both TSP-1 and CD47-encoding genes (i.e., THBS1 and CD47 , respectively) to be upregulated in ovarian carcinoma patients ( Figure 2 d), especially with elevated THBS1 mRNA expression in case of vascular and lymphovascular invasion ( Figure 2 e).

However, for these three sites, the effect of EDI at the beginning of the follow-up was borderline significant, with the lower bound of the 95% CI close to 1.00.

However, a trend towards such a difference was apparent, and with only 29 patients in group II (versus 120 in group I), this could potentially also be caused by a lack of statistical power.

Correlation analyses implied DC infiltration was somewhat linked to homing of T cells to MSI-H tumors but, overall, the association between APC and T cell frequencies displayed a negative trend regardless of MSI status.

CRC, a highly preventable disease, continues to remain the second most lethal cancer in the US with an increasing trend globally [ 1 ].

Patients with CD8 T RM -high, CD39+ CD8 T RM -high, and PD-L1+ CD8 T RM -high tumors showed a trend of better survival; however, the finding was not statistically significant ( Figure 4 ).