Excerpts

HRQoL data from the ASCEMBL trial comparing asciminib to bosutinib in patients with CML-CP previously treated with ≥2 TKIs showed a trend of improvement in the MDASI-CML and EQ-5D-5L scores in the asciminib arm, including fatigue, whereas there was a worsening of gastrointestinal symptoms in the bosutinib arm.

Although a numerical trend toward shorter PFS was observed with worsening LIPI categories in our cohort, this difference did not reach statistical significance.

Although CHIP carriers in the placebo arm exhibited only a nonsignificant trend toward increased major adverse cardiovascular events (MACE), patients harboring TET2-mutant CHIP derived substantial benefit from IL-1β inhibition with canakinumab [ 23 ].

Volumetric Reclassification at 3 and 6 Months Many post-PEF lesions classified as stable disease showed a negative trend, and % change in volume has been proposed as a more sensitive metric than Sum of Longest Dimensions [ 9 ].

T cell exhaustion markers, including CTLA4 , TIGIT , and LAG3 , showed a trend toward higher expression ( Figure 6 B).

All results are summarised in Supplementary Table S12 and highlight that some nominally significant findings—particularly in small treatment-defined subgroups—may be imprecise and prone to overestimation. 3.3.7.

As observed previously, the favourable prognostic effect of Regnase-1 in the total cohort and in surgery-only patients was lost—and shifted towards a negative trend—after adjuvant radiotherapy.

Panitumumab (OR = 864.77; 95%-CI: 191.84–3898.23) was the least favorable treatment regimen and was associated with a highly significant increase in the risk of acneiform rash.

Patients with resolved IEC-HS showed a trend toward higher CAR T-cell expansion.

In the multivariate analysis, no variable retained independent statistical significance, although molecular classification and prognostic risk group showed a trend toward association with recurrence ( Table 4 ).

They also identified a weak trend indicating that the relative risk of ovarian cancer increases with the duration and frequency of genital talc use [ 13 ].

Over the past few decades, the widespread expansion of cross-sectional imaging—such as ultrasound and CT—has driven a steady increase in detected cases; as roughly 60% to 67% of RCC cases are diagnosed incidentally, a shift that has led to a notable trend toward the detection of smaller, lower-stage asymptomatic tumors [ 1 , 2 , 3 , 4 ].

In the same context, the reduction in positive surgical margins (from 27% to 22%), combined with the decline in PSA persistence over time, suggests improved tumor localization, further experience with robotic platforms, and increasing operator experience, indicating a positive trend in surgical training and education at a national level.

The tisagenlecleucel vascular cutaneous signal was nominally significant but attenuated after excluding infection-attributable and cytopenia/bleeding-proxy reports.

Pairwise comparisons of biopsy plus 2, 3, or 4 diagnostic modalities revealed a positive trend for the combination of biopsy + PET + MRI + EMG-NCS.

A p -value < 0.05 was considered statistically significant, and a p -value < 0.001 was considered highly significant.

In this context, although several TRBV genes exhibited nominally significant differences between patient subgroups, only a restricted number remained significant after the Benjamini–Hochberg correction for multiple testing.

Comparisons that were nominally significant but did not survive FDR correction.

Other routine baseline variables, including age, diagnostic total hemoglobin concentration, WBC, platelet count, spleen size, liver size, sex, lymphadenopathy, and rash, did not show nominally significant differences between the two single-subtype groups.

The reasons why our results were superior to those in Francis’s report are unclear, but it may be significant that the current study had patients with older age, and medicated for longer periods as compared to Francis’s study.

Furthermore, continuous and dichotomous (+ve versus –ve) data yielded similar results, except for pERK which correlated with lymph node negative status, Ki67 which correlated with triple negative cases, and HER2 which approached significance with recurrence using continuous but not dichotomous scores.

α IIb β 3 expression was stronger in recurrent tumours (40% strongly expressing compared to 20% of non-recurrent tumours), and was identified as marginally significant for recurrence, whereas high expression of α 3 β 1 was highly significant as a prognostic indicator.

Moreover chemotherapy was associated with a shorter OS in “low risk” individuals (p = 3.67, 95% CI = 1.22–11.06, p = 0.0133), producing a highly significant qualitative interaction term.

Conclusions A greater understanding of how cancer cells hijack the OSM produced in the microenvironment near normal, premalignant, and fully transformed epithelial cells and block the initial JAK/STAT3-mediated tumor suppression signaling in favor of transformation and increased tumor heterogeneity is highly significant.

Verifying that a somatic variant does not exist in a heterogeneic tissue with low tumour cellularity poses the problem; what depth of coverage is needed to confirm a true negative result? The potential negative impact to patient and family members if they receive a false negative result for targeted NGS may be significant.