These findings are extremely significant, since they suggest that higher blood glucose levels, which may be related to the need for more energy expenditure to express high pancreatic cancer lesions, promote the elevated expression of RBM15 in pancreatic cancer.
Although our analysis by periods showed—through an internal and external comparison—a decreasing trend in the incidence of all cancers combined among KT recipients, we found no significant changes in the incidence over time for the major cancer types, with the exception of Kaposi’s sarcoma.
Unexpectedly, ADH5 was significantly upregulated in primary melanoma samples of one dataset and showed an increasing trend in melanoma in the other two datasets ( Figure 3 e, left).
A recent trial showed a trend of females receiving osimertinib (a third-generation epidermal growth factor receptor tyrosine kinase inhibitor) having improved survival over males; however, this result was not statistically significant [ 135 ].
PSMA-TLQ measurement differences gave a borderline significance with a p -value of exactly 0.05.
A highly significant difference of this group of patients compared to PDGFRA and PDGFRB rearrangements is their lack of response to first- and second-generation tyrosine kinase inhibitors.
In some instances, concerns with dose may be significant enough that PMRs or PMCs will not be sufficient recourse to address them.
Although lower, PBDEs emissions in soil and water may be significant for human exposure as well [ 11 ].
Although upregulation of FASN, GLUD1, and G6PD in the high-risk group barely missed statistical significance, these enzymes deserve attention given their biological significance in cancer and metabolism ( Figure 3 , Table S3 ).
Planning studies have identified reduced doses to the bladder, femoral heads, and bowel bag as possibly significant advantages of PT over xRT [ 23 , 24 , 25 ] for rectal cancer.
The reduction in ID for PT may be significant for younger patients with a longer life expectancy, as there is evidence of a reduced risk of secondary cancer induction when using PT as compared to xRT [ 22 , 46 ].
This may explain, in part, why so many nominally significant medical research results are not borne out by subsequent studies.
This may be highly significant, as BPH has been shown to be a strong predictor for developing PCa [ 52 ].
The length of hospital stay was shorter in the EUS-BD group, and there was a significant trend toward shorter procedure time with EUS-BD compared to ERCP.
GNAI2 demonstrated a gradual increase in expression levels among the IDH WTs and was highly significant for WHO grade IV types.
Although the initial AI-assisted accuracy was significantly higher in expert (91.9%) versus non-expert (82.3%) endoscopists, there was a significant trend over time in non-experts, such that, for the final 50 polyps, there was no difference in NPV for non-experts (95.2%) versus experts (93.9%).
However, there was a significant trend in etiology between these three groups.
Therefore, precision RT has emerged as a significant trend in the advancement of RT technology to reduce damage to normal tissues.
However, an overall trend for decreased PFS was noted in MMR-deficient gliomas [ 98 ].
In a French nationwide healthcare database sample of 3853 breast cancer patients, radiotherapy-treated patients had 28 permanent pacemaker implantations compared with 13 expected cases, corresponding to a standardized incidence ratio of 2.18, although the direct comparison with non-irradiated breast cancer patients was only borderline significant [ 193 ].
While no significant association between PIK3CA mutations and recurrence-free interval was observed overall, a strong trend for impaired recurrence-free interval was noted in hormone receptor-positive breast cancers with PIK3CA mutations (adjusted HR 1.64), and a significantly detrimental prognostic impact was observed in hormone receptor-positive, HER2-negative patients treated with aromatase inhibitors alone (adjusted HR 4.44) but not in tamoxifen-treated patients, suggesting that estrogen deprivation may be ineffective in the presence of PIK3CA mutations [ 57 ].
The authors in these two independent studies found that there is a highly significant correlation between the level of Wnt signaling, the position of the tumor in the colon and the promotion of tumorigenesis.
High waist circumference (HR: 1.12, 95% CI: 1.04, 1.20), elevated cholesterol (HR: 1.07, 95% CI: 1.01, 1.13), and high blood pressure (HR: 1.11, 95% CI: 1.05, 1.17) were each significantly associated with higher risk of breast cancer among postmenopausal women, and there was a clear trend in increased risk with increased number of MetS components among postmenopausal women.
The result of another meta-analysis of observational studies [ 36 ], two of which overlap with the previous meta-analysis [ 30 ], indicated a borderline non-significant 11% increased risk of breast cancer in postmenopausal women with MetS in cohort studies, a two-fold increased risk in studies with other study designs, and a 52% increased risk overall.
MCPyV seroprevalence studies performed in China (61% overall) and the Czech Republic (63%) yielded similar results with an increasing trend with age [ 41 , 42 ].