Excerpts

Although not statistically significant, elevated post-induction CA 19,9 levels showed a trend toward association with shorter post-recurrence survival.

However, there may be significant differences in the management and treatment of lung cancer in its early stages that contribute to disparities in rates of mortality and incidence among rural vs. urban communities, as will be explained in the next section. 4.2.

There was a significant trend towards an improved response at 3–6 months if the DSM-TACE was administered in a selective vs. non-selective manner: at 3–6 months, complete response (CR) was 26.9% (7/26) vs. 7.3% (8/110); while partial response (PR) was 26.9% (7/26) vs. 19.1% (21/110), with p = 0.026.

Significant prognostic predictors were identified, including PG-SGA symptom assessment (HR = 1.068, 95% CI: 1.001–1.131), disease status (HR = 2.054, 95% CI: 1.551–2.721), and GLIM handgrip strength (HGS, HR = 1.424, 95% CI: 1.175–1.725), while food intake showed borderline significance (HR = 1.124, 95% CI: 0.999–1.264).

In the Cox regression model, HPV16 positivity showed a trend toward an increased hazard of progression to CIN3, although the estimate was imprecise and did not reach statistical significance ( p = 0.146) ( Table 2 ).

19.7 months; HR 0.80; p = 0.018) and a favorable trend in OS (54.3 vs. 48.3 months) compared to those receiving the NACT-first sequence [ 17 ].

Patients with a Sister Mary Joseph nodule showed a trend toward better survival outcomes.

Compared with MTAP wild-type tumors (median 63 years, IQR 55–69), patients with MTAP deletion showed a trend toward older age; however, this difference did not reach statistical significance (Wilcoxon rank-sum test, p = 0.069).

However, as shown in Figure 8 , although an increasing trend in the fibrosis index was observed in ECE-positive cases, these differences did not reach statistical significance.

Statistical significance was defined as p < 0.05 and p < 0.01 was considered highly significant. 3.

The wide confidence intervals reflect the small number of events in the G1 category (only one death among 11 G1 patients, resulting in 9% mortality); this limits statistical power but nevertheless demonstrates a clear trend.

Tumor-related factors: Tumor ulceration and necrosis showed a trend toward worse survival but did not reach statistical significance (HR = 0.52 for absence vs. presence; 95% CI: 0.23–1.16 and p = 0.112).

Associations of the density of cells positive for neuropilin-1 (NRP1) with patient survival in the authors’ own cohort failed to reach statistical significance, likely because of the small sample size (39 patients), although there was a clear trend towards an association between high NRP1+ cell content and poorer survival in the sonic hedgehog (SHH) and non-Wingless (WNT)/SHH MB subgroups.

Over the years, there has been an increasing trend in the use of ICG in surgery [ 27 ].

Although the majority of patients in the IOM cohort have an age of menarche at or below twelve, the risk class sub-analysis within the two categories (≤12 and >12) does not reveal a clear trend ( Figure 3 B).

In our study, stratification by FIGO stage showed a trend toward worse prognosis for G-EAC compared with usual-type endocervical adenocarcinoma, though not statistically significant, likely due to limited follow-up and sample size.

Among the remaining predictors, age showed a limited and element-specific effect, reaching borderline significance only for Mg (B = 0.77, 95% CI: 0.00 to 1.54), while confidence intervals for most other elements crossed zero.

Higher-grade tumors were associated with increased levels of Ca, P, Mg, and Mn, while Na and K showed a decreasing trend with tumor progression.

Pb showed an increasing trend after menopause, with higher values in postmenopausal patients, reaching significance in some comparisons (notably in A and C).

HRQoL data from the ASCEMBL trial comparing asciminib to bosutinib in patients with CML-CP previously treated with ≥2 TKIs showed a trend of improvement in the MDASI-CML and EQ-5D-5L scores in the asciminib arm, including fatigue, whereas there was a worsening of gastrointestinal symptoms in the bosutinib arm.

Although a numerical trend toward shorter PFS was observed with worsening LIPI categories in our cohort, this difference did not reach statistical significance.

Although no significant association was found between the response criteria and progression ( p > 0.05), functional imaging showed a trend toward better correlation with longer progression-free survival.

For some of the highly significant pathways, they were presented in a concentrated manner.

Although CHIP carriers in the placebo arm exhibited only a nonsignificant trend toward increased major adverse cardiovascular events (MACE), patients harboring TET2-mutant CHIP derived substantial benefit from IL-1β inhibition with canakinumab [ 23 ].

Volumetric Reclassification at 3 and 6 Months Many post-PEF lesions classified as stable disease showed a negative trend, and % change in volume has been proposed as a more sensitive metric than Sum of Longest Dimensions [ 9 ].