Excerpts

Noteworthy, the phosphorylation of Ser 555 results as a specific process, since the pUIk1(Ser757)/Ulk1 ratio was unaltered under all different experimental conditions; only in Dexa-2d and Dexa-6d cells a barely significant increase of this ratio was observed.

Thus, rapamycin-injected mice were smaller and weighed less than DMSO-injected mice—an effect that was highly significant ( Figure 4 D).

CMC2.23 at 20 μM showed a trend for reduced TYR and MITF but the levels did not reach statistical significance ( Figure 3 F).

The IFX t1⁄2 substantially decreased with increased platelet count in HR and RR individuals, so the contribution of platelet-mediated elimination became highly significant at high platelet counts in these individuals.

Besides gyrA and parC , which passed our p -value cut off (5.21 × 10 −7 ), we could find mutations in less-studied genes involved in modifying target enzymes, such as gyrB and parE , as well as in the genes involved in alterations of permeation, such as acrB , ompC , mdtK ( norE ), and mdfA , which did not pass our p -value cutoff but were mildly significant ( p -value around 5 × 10 −3 ).

Then, we applied association analysis between variants and antibiotic resistance phenotypes to reduce high-quality to highly significant variants.

Highly significant increases in plant biomass were observed under drought stress.

In an analysis of patients with febrile seizure, patients with prolonged seizures showed a trend for higher IL-1β and lower IL-1RA levels in blood samples than in controls [ 63 ].

Butanoic acid propyl ester showed a trend towards an increase and (z)-2-butene and acetoacetate methyl ester towards a decrease in mice gavage fed with (S)-reutericyclin.

Indeed, the subfraction HbA1c, glycated at the amino-terminal valine residue of the β chain, may be significant with increased level of blood glucose over prolonged periods of time and, for this reason, is considered an important biomolecular marker for evaluating long term control of diabetes.

A highly significant positive association was observed between TRS with FOLRN (r = 0.50), SOLRN (r = 0.65), LRS (r = 0.42), RLD (r = 0.99), RV (r = 0.77), SRN (r = 0.42), SDW (r = 0.52), RDW (r = 0.70) and RL (r = 0.71).

In that study, serum PCT level showed an increasing trend along with the worsening residual renal function (indicated by the decreasing estimated glomerular filtration rate (eGFR)) irrespective of the existence of infection ( Figure 2 A) and AKI ( Figure 2 B).

Different from the cell membrane TLRs, the expression of intracellular TLR genes, including Tlr3 , Tlr7 , Tlr8 , and Tlr9 , showed an increasing trend during heart development ( Figure 1 D).

Additionally, GM-MDM(LPS/IFNγ) showed a trend toward higher IL-12p70 production relative to M-MDM(LPS/IFNγ) and Mob-MDM(LPS/IFNγ); however, this difference did not achieve statistical significance ( Figure 1 ).

This study only showed an overall trend, but with no statistical significance, toward increased secretion of both cytokines by GM-MDM(LPS/IFNγ) relative to M-MDM(LPS/IFNγ).

[ 2 ] in a systematic review reported that the annual incidence of severe burns was 0.2 to 2.9/10.000 inhabitants with a decreasing trend in time.

In the OT2 Rag Tx, OT2 Tx, and WT Tx mice, we found a similar highly significant correlation of the percentage of PD1+ CD4+ T cells with the amount of endogenous Vb5neg T cells (Vb5neg fraction: OT2 Rag mean 56.6%, SD 16.8%, n = 4; OT2 mean 35%, SD 17.3%, n = 12; WT mean 91.5%, SD 1.8%, n = 12) ( Figure 3 G).

Raw concentrations and creatinine adjusted values of the two urinary markers however showed highly significant correlations.

We in addition observed a negative trend of urinary EGF values with age in the ADPKD cohort (Spearman rho = −0.36) as well as a positive trend of serum VIM levels with age in the CKD cohort (Spearman rho = 0.44). 2.5.

The expression of Col1a2 , which is known to be increased by VC, was significantly increased by day 3 after calcification induction in αMEM (-) and showed an increasing trend in cells cultured in αMEM (+).

In this case, the analysis of concordant SNPs revealed highly significant overlaps, especially for the 1% most significant SNPs together present in Endometriosis and Migraine (85) compared to those that were discordant (43), revealing a 3.61 Odds Ratio compared to the null hypothesis ( p = 7.2 × 10 −4 ).

It is nevertheless important to notice that except for specific population where strong bottlenecks occurred, the relative risk provided by each risk allele is always less than 1.4, with p -values that are clearly significant due to the quite large number of patients analyzed in each of the studies, this number being even increased by gathering of samples in subsequent meta-analyses.

Also, catalase activity showed a trend to increase in both examined brain areas after chronic stress and this may be in response to the intensification of oxidative stress.

Although statistically significant results were observed only with HDR, a slight trend of positive association of radiation dose and inflammatory cells was noted for the 100 mGy dose as well.

Notably, an increasing trend in the proportion of various subpopulations of immune cells involved in inflammation was observed.