Excerpts

Many top-ranked features showed absolute Pearson and Spearman correlation coefficients exceeding 0.65, with highly significant p -values even after Bonferroni correction ( Table 11 and Table 12 ).

Despite a clear trend indicating higher VEGF levels in the tumor group, the statistical analysis did not find these differences to be statistically significant.

Among the other covariates included in the model, pathologic tumor stage ≥ pT3a showed a trend toward association with tertiary Gleason pattern 5 but did not reach statistical significance (aOR, 2.14; 95% CI, 0.98–4.86; p = 0.061).

Conversely, the lower occurrence of such paroxysmal EEG patterns in the CMV-seropositive cohort, alongside the lack of differences in the SCoRS global rating or total score, might tentatively reflect a subtle, chronic viral-induced exhaustion of these plastic compensatory mechanisms—a pattern potentially consistent with frontally mediated network mechanisms [ 62 , 63 ] that manifests nominally as a slight trend toward disorganization.

Following strict multiple comparisons correction, these findings were attenuated to strong, near-significant nominal trends ( p BH = 0.067 and p BH = 0.060, respectively).

While this difference achieved high nominal significance prior to multiple comparisons correction (Yates-corrected p = 0.003), it retained only a marginal significance after Benjamini–Hochberg adjustment ( p BH = 0.087).

Within background rhythm morphology, alpha activity with sharply contoured morphology demonstrated a strong trend toward an association with CMV serological status, being observed more frequently among CMV-seronegative patients (20.00%) compared with CMV-seropositive patients (2.94%).

Measurements showed an increasing trend.

In this study, the borderline significant association between dyslipidemia and disease duration suggests that the cumulative impact of SLE over time may increase cardiovascular risk factors.

Accordingly, the findings of this limited size cohort should be interpreted as an associative trend that require validation in future prospective studies.

17.0%), while pneumothorax rates were similar, with a nonsignificant trend toward higher incidence in the smaller-probe group.

In contrast, psychiatric prescription drugs were the main poisoning substances in the 12–14 years age group, showing an increasing trend from 14 cases in 2019 to 120 cases in 2024 ( Figure 5 ).

In the IDEAL-LM study that included 818 patients undergoing LM PCI, a biodegradable-polymer everolimus-eluting stent followed by 4-month DAPT demonstrated noninferiority compared with a durable-polymer everolimus-eluting stent followed by 12 months of DAPT, although a numerical trend toward higher ischemic event rates was observed in the biodegradable polymer stent with the 4-month DAPT group [ 73 ].

Regarding the 3-month mortality, near-significant differences between groups may reflect baseline differences in disease severity.

An additional limitation relates to the relatively small sample size of the thermochemotherapy group, which may have reduced statistical power and contributed to the borderline significance observed in multivariable analyses.

Similarly, OCT-NFCT showed a decreasing trend with increasing myopia.

Vascularization We observed a highly significant reduction in most hemodynamic parameters.

It is important to be precise about what this evidence does and does not show: a documented decline in open operative exposure is an established trend, whereas a resulting decline in open competence is a reasonable concern that the available data do not directly demonstrate.

Increasing age demonstrated a trend toward significance ( Table 3 ).

Backed by confirmed efficacy and safety by randomized controlled trials (RCTs) in different patient cohorts [ 1 , 2 , 3 , 4 , 5 , 6 ], there was already a clear trend across the world to adopt TAVR in AS patients <75 years, even in patients <65 years who are potential candidates for mechanical surgical valves, which is outside of current guideline recommendations [ 11 , 12 ].

All tests were two-sided, and p -values < 0.05 were considered nominally significant.

The model showed a strong and highly significant association between baseline and follow-up risk classification, with each unit increase in baseline H 2 FPEF score associated with substantially higher odds of a worse risk category at follow-up (odds ratio [OR]: 21.01; 95% confidence interval [CI]: 8.81–50.10; p < 0.001).

Although these relationships are weaker to moderate in magnitude, they remain highly significant, indicating that prolonged sleep onset, frequent nocturnal awakenings, shorter sleep duration, reliance on pharmacotherapy, and lower sleep efficiency are all significantly linked to higher levels of depressive symptoms. 3.7.

UST and MRK showed a positive trend toward maintaining clinical response; however, the 95% CIs were wide and crossed the null value, indicating limited certainty of evidence ( Table 3 ). 200 mg GUS (RR: 3.34, 95% CI: 1.95–5.72, SUCRA = 96.8) and 100 mg GUS (RR: 3.05, 95% CI: 1.77–5.25, SUCRA = 83.2) ranked first and second, respectively ( Figure 6 b).

13.0%) in the EV (+) group (both p = 0.051), suggesting a possible trend toward increased systemic complications.