Excerpts

However, we observe only a slight trend towards more generations in individuals with younger C 14 dates (Fig. 3a ), which suggests that the process of admixture with steppe-related ancestry occurred over several hundred years rather than as a single pulse.

Importantly, all ROIs displayed a numerical trend of higher context-trial pattern similarity on congruent than incongruent trials in the Same CTD condition, with right dlPFC/frontopolar cortex and left inferior frontal junction reaching statistical significance (Fig. 4c–f , dot graphs; Table 1 ).

Blocking mPTP with CsA showed a trend towards decreasing the number of neurons with caspase 3/7 activation (Supplementary Fig. 8 ).

Therefore, mutations resulting in ΔΔ G (SPR) > | 0.2 kcal mol −1 | are likely to be significant.

The data points appear to be quite scattered and we do not observe a clear trend in this plot.

Two other neuroimaging phenotypes showed nominally significant effects on depression, including higher MD in the ATR for MR-Egger (tMD-ATR; β = 0.107, p for MR-Egger = 0.028, p FDR = 0.166; however, the Egger intercept was not significant, p FDR = 0.432, Supplementary Fig. 11 , Supplementary Data 6 and Supplementary Table 3 ) and ICVF in SLF (tICVF-SLF; β = −0.025, p = 0.030, p FDR = 0.179 for IVW).

Numerous highly significant interactions were inferred between mo-Macs and aggressive/metastatic tumor cells involving the activation of TNF, TGF-β, and EGFR signaling pathways in tumor cells; these interactions may induce ERK-MAPK signaling, invasive mesenchymal phenotypes, and tumor growth.

Confirming this, we found a highly significant interaction between group polarization and arrival order in the time taken to reach the stimulus (LMM: estimate = −0.026 ± 0.0032, Kenward–Roger F-test: F 1,1998 = 67.9, P = 3.1 × 10 −16 , Supplementary Table 6 ); in other words, the effect of polarization was dependent on the arrival order.

There was a marginal trend that compensation was overall larger for dichotically presented perturbations applied to vowel compared to consonant acoustics ( F (1, 31) VowelvsConsonant = 3.18, p = 0.08, estimate vowel = 0.39, SE = 0.012, t (36) = 3.33, p = 0.002; estimate fricative = 0.013, SE = 0.012, t (36) = 1.03, p = 0.31).

We tested these genes on an independent dataset of 4,877 cases and 6,203 controls, HIST1H1E showed nominally significant (Supplementary Table 3 ).

Although viral load is influenced by many factors, we nevertheless observed a clear trend for patients with high viral load to have frameshifting rates close to “wild type” (the lab strain HXB2).

At least in the case of TNFα treatment, exclusion of ABCC1 from the LAMP1-LysoTracker compartment was highly significant, whereas IFNγ or MK571 treatment showed only marginal decline (Fig. 2m ) leaving an impression that ABCC1 is probably directly involved in bacterial killing.

Therefore, both these analyses suggested an overall trend toward increasing precipitation variability along with decreasing evaporation variability, reinforcing our main conclusions.

Pathway-level methods were also more robust against batch effects, thus enabling the aggregation of data from various cohorts, resulting in highly significant biomarkers 18 – 22 .

However, using the PathOlogist activity scores, we identified 9 significant ( q ≤ 0.05) and 31 near-significant (0.05 < q ≤ 0.25) pathways in both microarray and RNA-seq datasets.

TF13 asks by what time two differently forced simulations of annual mean surface temperature differ by more than the internal variability, and quantify emergence as the time when a significant trend can be found in the difference between two simulations.

Besides, we observed a highly significant correlation and concordance between the identity of the rearranged IGHV gene sequences obtained by IgCaller and SSeq/NGS.

In addition, areas AM and RL were trending toward significance, but areas AL, LI, and S1 did not show significant retinotopic anisotropy in coherent motion correlation (Fig. 5j ; V1: −0.81 ± 0.05, t 9 = 5.3, −10.3, p = 1.4 × 10 −6 ; LM: −0.44 ± 0.08, t 9 = −3.3, p = 4.3 × 10 −3 ; AL: 0.03 ± 0.14 , t 9 = −1.1, p = 0.85; PM: −0.78 ± 0.06, t 9 = −8.9, p = 4.5 × 10 −6 ; LI: −0.04 ± 0.11, t 9 = −0.6, p = 0.73; RL: −0.27 ± 0.10, t 9 = −2.1, p = 0.035; AM: −0.36 ± 0.14, t 9 = −2.0, p = 0.036; S1: −0.14 ± 0.09, t 9 = −1.3, p = 0.11; Bonferroni-corrected threshold p < 0.006, mean ± s.e.m., single-sample t test).

A clear trend can be seen from the following optical images (Fig. 2a, d; Supplementary Fig. 2a–c ).

Of note, the assistance of other proteins, in burying the long alkyl moieties when expelled from FasR and other lipid-sensing TFRs should not be ruled out, as they might be significant components of the thermodynamic equations.

However, these putative elusive cancer genes did often displayed a tendency towards significance in the MutSig2CV analysis, likely reflecting a limitation of the cohort size (Supplementary Fig. 16 ).

Principal component analysis (PCA) showed a trend to separate both the metaproteome and the lysine acetylome for CD versus control (Fig. 4a , b).

The composite TM δ 18 O record, constructed by averaging the three speleothem isotope profiles for the periods of overlap, displays an increasing trend through much of the Holocene (Fig. 2a ), with values increasing by ≈2‰ between the early and late Holocene.

While the higher resolution δ 13 C and Mg/Ca records show more structural features, the increasing trend in these proxies from ≈5 ka is matched by a decreasing trend in DCP approaching 4 ka, after which the trends are amplified until ≈3.7 ka.

Metabolite identification using structural ontologies showed a trend towards regulation of sulfur metabolism pathways (Supplementary Fig. 5a , Supplementary Data 1 ), however enrichment analysis did not reach statistical significance.