Among other nutritional assessment methods, the univariate analysis showed a trend toward an increased risk of malnutrition in patients and reduced ADL by CONUT (OR 1.22, CI 0.28–2.56, p = 1.000), while the multivariate analysis showed a decreased risk for reduced ADL, possibly due to confounding variables (OR 0.42, CI 0.04–4.74, p = 0.484).
To do this, each factor was first compared with functional decrease, and those factors that were significant or close to significance ( p < 20), were used in a logistic regression model by steps.
Muribaculum also showed an increasing trend in the H and HB groups, and the abundance of Corynebacterium was slightly lower in the H and HB groups than in the C group.
As mentioned above, higher psychosocial burden and poorer HRQoL were observed in boys and young men; however, in another studygirls showed clinically worse HRQoL than boys (mean difference 0.71), although this difference was only marginally statistically significant.
Similar findings were observed by per-protocol ( Table S1 and Figures S1–S13 ) and LMM ( Table S2 ) analyses; neither dosages of ACNs significantly affected vascular and CVD risk variables, although a relatively low level of RC was observed in the 320 mg group at 3 m change% while an elevated level was observed in the 640 mg group with marginal significance ( P overall = 0.018~0.051).
The primary findings revealed that positive associations were observed only among APOE4 carriers: individuals with higher TC1 scores exhibited a slower rate of cognitive decline, whereas those with higher TC2 scores showed a trend toward accelerated decline.
Similarly, in rectal cancer patients, the KD significantly reduced body weight and fat mass and showed a trend towards improved pathological tumor responses [ 10 ].
In contrast, Model 4 has shown a suggestive trend in the likelihood of abdominal obesity between Tertile 1 and 3 (OR T3 vs.
7.7%, p = 0.052) showing borderline significance ( Supplementary Materials, Table S2 ). 3.3.
Although no significant differences in anemia by age were observed, a decreasing trend with increasing age was noted, consistent with broader evidence [ 63 ]. 4.2.
A 12-week administration of GABA-rich Chlorella significantly reduced systolic blood pressure, while diastolic blood pressure showed a decreasing trend [ 25 ].
Food intake showed a decreasing trend over time (Week 1 vs.
Protein intake showed an increasing trend between 12 and 24 months, possibly reflecting improved dietary adaptation or increased awareness of preserving muscle mass during weight loss.
Results are shown as mean + SD; p < 0.05 was regarded as significant and p < 0.01 as highly significant. 3.
In the CKDB-322 group, triglyceride levels showed a favorable trend, decreasing by −17.48 ± 61.32 mg/dL, while the placebo group experienced an increase of 12.33 ± 53.06 mg/dL.
Age and polypharmacy did not reach statistical significance but showed a trend toward association with the outcome.
Significant group × time interactions were found for cortisol in females and cortisone in males, while amylase showed a trend toward interaction in females.
However, GS4 and GS5 (family acceptance of illness and communication about the disease) showed p -values close to statistical significance ( p = 0.09 and p = 0.06, respectively), suggesting a possible trend toward improvement in these domains.
Near-significant trends in GS4 and GS5 (acceptance and communication within family) may reflect gradual increases in perceived social support.
These findings suggest that, despite an overall trend toward improvement, some patients experienced deterioration in selected QoL domains, highlighting the importance of individualized therapeutic support.
However, given the modest sample size and near-significant between-group differences for HRV and coherence, these findings should be interpreted cautiously as hypothesis-generating rather than definitive.
p < 0.05 indicated significant differences, and p < 0.01 indicated highly significant differences.
Conclusions In conclusion, the findings of this study identified a marginally statistically significant positive correlation between circulating 25(OH)D 3 levels and mtDNA-CN in peripheral blood cells within the elderly population.
Results of this study showed a higher percentage of children born to women with a lower iodine status during pregnancy, including those classified as having a mild-to-moderate deficiency, had suboptimal cognitive outcomes; meanwhile, a significant trend towards a lower risk of suboptimal classification with increasing maternal iodine status was also observed [ 147 ].
While only nominally significant, baseline executive function increased with each A allele, and after 3 years, participants homozygous for G (lowest performance at baseline) saw greater improvement in executive function; no interaction with diet assignment was observed.