Excerpts

CCL3 also appears to be downregulated in a similar fashion, to the extent that it approaches statistical significance ( Figure 2 ).

In the present study we characterized the DNA methylation pattern in diagnostic pediatric T-ALL samples using genome-wide promoter focused methylation arrays identifying two subgroups with highly significant differences in clinical outcome.

There was a significant outcome by streak interaction (F(1,17) = 4.85, p = .04), indicating that subjects showed a trend toward win-stay-lose-shift after short streaks, but no such pattern after long streaks.

There was a slight trend of decreases in bet size after a series of wins, but this was not significant.

Unlike GWASs, P-values for SNPs associated with genes were generally moderately significant and only a few of them would qualify at the so called genome-wide significance level.

(3) Although there were positive interactions between WMH pathology and Aβ deposition on FA in the internal capsule and parahippocampal white matter, accounting for apoE genotype rendered these interactions only marginally significant.

Our findings of a positive trend between TV-viewing at 45 y and subsequent BMI and, less consistently, for work sitting, are specific to mid-adulthood.

Implications and conclusions In summary, we found an increasing trend of higher 45–50 y BMI gain with higher TV-viewing at 45 y and although no trend was seen for work sitting, there was a detrimental effect on BMI gain for those sitting for 2–3 h/d.

There was no linear trend between time spent sitting at work and 45 y and 50 y BMI (Model 1, Table 2 ), but a negative trend with BMI change 45–50 y, i.e.

The M-ratio test, however, produced highly significant results for both these populations, as well as for Sobrado, Queixa, Courel-L9B and Vegarada.

In Table 4 we show that in different historic moments, a highly significant correlation between high RCA in science and fast economic growth in the following year can be demonstrated.

There has been a positive trend toward increased use of experimental designs and methods, particularly in the past three years.

Similar patterns were observed in the analyses by HDI, with stronger, significant associations seen in lower resource settings for nutrition counseling (RR = 5.11, 95% CI: 2.95–8.87) and a trend towards significance for vaccinations (RR = 1.27, 95% CI: 0.98–1.63).

For an overall trend, mean performance levels were calculated.

A network analysis identified numerous highly significant networks with a score ≥3 that were down- or up-regulated in HepG2 and Huh7 cells upon combined SOR+CLX treatment.

A significant negative correlation with borderline symptom severity was observed within the ROI-analyses of the dorsal ACC (r = –.56), and a statistical trend for the bilateral amygdala (r = –.49) (see Table 1 and Figure 1b ).

Each of these two suppressors resulted in a highly significant improvement in the transient transformation efficiency, as shown by up to a 4.6-fold and 3.6-fold increase in the EYFP expression level at 192 h after bombardment, respectively, when compared to the control (absence of a suppressor) (expression level: 0.70×10 5 ±0.10×10 5 ) ( Figure 2b ).

P values equal to 0.001 were considered as marginally significant.

Of particular note is that the body weight difference is highly significant even at 4 weeks of age (WT = 74.2±2.4 grams; KO = 86.4±3.0 grams).

Interestingly, only the allelic model, which was not consistent with the HWE, yielded a marginally significant risk of hypertension (OR = 1.18, 95% CI = 1.06–1.33), but no evidence of an association was found in the source of the control studies (controls were population-based or hospital-based).

Further, since many studies were underpowered, some results were not statistically significant (and therefore not reported here) but showed a trend towards significance.

Additionally, H460 IID10 had an increased mean cell volume and showed a trend towards decreased plating efficiency as well as decreased colony radius, possibly due to the detachment of cells from the colonies.

Notably, both HK2 siRNA transfected ADPGK -null cell lines showed an additional highly significant ∼4-fold loss of clonogenicity ( Figure 5D ), with no further change in colony size, compared to WT also treated with HK2 siRNA.

Two days after transfection with control siRNA, cell numbers of knockout clones were not significantly different from WT, although a small trend towards reduced proliferation was noted for H460 IID10 as above ( Figure 5B ).

Two-tailed levels of significance less than or equal to 0.01, 0.05 and 0.1 were considered as “highly significant”, “significant” and “suggestive”, respectively.