Barely Significant

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marginally significantP = 0.05748921.1× alphagold
Hence, using two-factor repeated-measures ANOVA across time, the lower Mtb load in co-cultured macrophages as well as macrophages co-cultured with LAG-3 silenced blood-derived T-cells, was marginally significant ( P = 0.0574892) relative to infected macrophages ( P <0.01) at 96h ( Fig 3A ).
The majority of study participants who progressed to this combined endpoint met the CD4 criterion (15 versus 17 for prednisolone and placebo, respectively), whereas only a much smaller fraction of study participants reached the clinical endpoint “onset of AIDS-defining condition” (4 versus 11), and differences in this purely clinical endpoint did not quite reach statistical significance (p = 0.0575).
partially significantp = 0.0581.2× alphaqualifiedgold
After further exclusion of patients who used a PRL-raising AP from the analyses only the patient-control comparison in femoral BMD changes remained partially significant (total BMD: B = 0.032, 95% CI -0.001 to 0.066, p = 0.058; Z-score: B = 0.269, 95% CI 0.012 to 0.526, p = 0.040; and T-score: B = 0.254, 95% CI 0.001 to 0.508, p = 0.049).