Accordingly, although there were overlapping CIs for hazard rate ratios, the difference in risk of CV death between ACEI-treated patients with ischemic versus non-ischemic CHF, showed a trend for increased risk of CV death with increasing score A in patients with ischemic CHF (P = 0.332 [ Fig 4 ]).
These associations were non-linear, but with a significant trend in odds of diabetes with increasing bilirubin among men (men: p-trend = 0.003, women: p = 0.34).
bevacizumab group, pemetrexed did not exhibit an obvious change in PFS (HR = 0.96, p = 0.752; I 2 = 35.8%, p = 0.212) or OS (HR = 0.98, p = 0.744, I 2 = 0.0%) but exhibited a slight trend to reduce grade 3–4 AEs (HR = 0.79, p = 0.343, I 2 = 65.7, p = 0.088).
However,decreased BMI(median OS 8.9 vs 9.3 months; HR 1.218, 95% CI 0.936–1.585; P = 0.142; Fig 4B ) showed a trend to worse prognosisand BMI at diagnosis did not influence on OS ( P = 0.357).
However, when the same comparison was performed after separating major (intracranial, gastrointestinal or any other type of bleedings requiring blood transfusion) from minor bleedings, we found a significantly lower incidence in minor bleedings in favor of the NOACs (RR = 0.69 95% CI 0.56–0.85; p = 0.0003) ( Fig 5A ), while no statistically significant difference in the incidence of major bleedings was evident, despite a clear trend in favor of the NOACs-treated arm (RR = 0.82 95% CI 0.53–1.25; p = 0.36) ( Fig 6 ).
Minimal regulation of pleiotropic immunomodulatory cytokines Regarding the pleiotropic cytokines, a slight trend towards an IL-13 (control: 3.12±0.19 pg/ml, DR: 2.85±0.14 pg/ml; p = 0.36; Fig 2C ) down-regulation was observed in DR samples.
After controlling for other variables, there were no differences when comparing odds of ideation among females to males in the depression cohorts (OR = 2.3, 95% CI: 0.75–6.98; p = 0.14), nor was there a significant trend among age categories (p = 0.37).
When looking at the linear frequency domain, for LF/HF, only a slight trend with small effect size towards a decreasing ratio value after yoga intervention could be identified (p = 0.383, g* = -0.263).
patagonica did not differ between the two locations (La Hormiga and El Hormigón; two-way ANOVA comparing abundance of open spaces associated to coral colonies among locations, main effect location: F 1,3,1501 = 0.0152, p = 0.9093) or over time, despite showing an increasing trend (2005, 2006, 2007, 2010; main effect time: F 3,- = 1.4271, p = 0.3886).
There was no evidence of a decreasing trend in catch at 10 m (estimate = 0.085, ± SE = 0.098, p = 0.39) or 25 m (estimate = 0.096, ± SE = 0.082, p = 0.24).
When edaravone was added to tPA-treatment at 1 h (E + tPA 1 h), the mortality rate was similar to those received tPA alone (27.7%), but the infarct size showed a trend of further reduction (15.5%, p = 0.40 compared to the tPA-treatment alone).
This lower performance in ALT in the immediate test was due to a (marginally significant) performance drop of performance in ALT from the last 5 trials at the end of training (at which time there was no difference (two tailed t -test, P = 0.40) between ALT and LONG-ITI) to the first immediate test ( P = 0.05) Dissociation of time and interference-induced between-trial forgetting Between-trial forgetting due to either time or interferences or both during training was assessed by taking the difference in performance between conditions (see Methods ).
However, young women had a reduction in their experiences of physical IPV at the hands of their husbands in the past year (10% - 4.4%, β = -0.08, p-value = 0.077) also approaching conventional statistical significance, while older women reported a slight increase in experiences of physical IPV (6% - 9.6%, β = 0.03, p-value = 0.404).
Although, there is an increasing trend, no significant correlation (Spearman’s rho = 0.108, p = .410) is found between expression level and tumor stages.
For the context test, while we did not find any main effects there was a strong trend for an effect of the demonstrator’s sex ( Fig 2B ; two-way ANOVA, OBSERVER’S SEX: F 1,27 = 0.6907, p = 0.4132; DEMONSTRATOR’S SEX: F 1,27 = 3.914, p = 0.0582; OBSERVER’S SEX x DEMONSTRATOR’S SEX: F 1,27 = 3.600, p = 0.0685; N = 7–8 per group).
However, at 15 U/kg/wk doses, the Vela-injected mice showed a trend toward greater (∼66%) reductions of GC levels compared to ∼55% in Imig injected mice (p = 0.42).
Although there was a decreasing trend of mean water content from the W1 to W4 treatment, no significant difference was found ( P = 0.43).
Analyses revealed a small but significant overall effect of distributing practice on acquisition performance ( η 2 = .127, p <.001) and a marginally significant effect on retention performance ( η 2 = .108, p = 0.44).
A weak trend of sBAT-R 2 * normalization was observed after reheating (0.15±0.70 s -1 , P = 0.441 compared to the Baseline MRI and -0.50±1.33 s -1 , P = 0.173 compared to the Cold MRI ) ( Table 1 , Fig 3B ) whereas SAT-R 2 * remained increased (0.47±0.55 s -1 , P = 0.028 compared to the Baseline MRI and 0.07±0.49 s -1 , P = 0.767 compared to the Cold MRI ) ( Table 1 , Fig 3B ).
The intermediate risk group showed a trend to reduction in mortality (17.8% to 10.3%, aHR 0.82, p = 0.46) which was not observed in the low risk group (7.8% to 9.2%, aHR 1.4, p = 0.31).
Among the total study population, RICI showed a decreasing trend (y = –0.6571x + 89.571, p = 0.462), whereas UAO and Tumor showed an increasing trend (y = 2.2044x + 23.824, p = 0.091 and y = 1.4769x – 0.9341, p = 0.001, respectively).
Control mice ( Fig 3A ) showed a trend to interact more with the novel object (not significant, p = 0.466) and Tg2576 mice showed a trend to interact less with the novel object (not significant, p = 0.257).
The same trend was not observed for bacteria – inoculation treatment only had a weakly significant effect on the community composition of bacteria (multivariate PERMANOVA, F 3,52 = 0.100, p = 0.47, R 2 = 0.054) ( Fig 6B ).
Among T cell subsets, the expression of CD8a (p = 0.055) approached significance but CD8b (p>0.5) did not differ significantly from expression in the normal ovary.
Although none of the turns showed a statistically significant difference in the SM area ( Fig 5C ), we observed a trend toward significance in the apical turn with a large effect size (two-way ANOVA, interaction: F (2, 24) = 0.72, p = 0.50; Šidák post hoc test: p = 0.052, Cohen d = 2.05).