Excerpts

Proteins with CV-VIP >1.0 were selected and then a new regression based on these selected proteins was performed (R 2 = 0.81, Q 2 = 0.65) with a CV-ANOVA p < 0.001 and thus a highly significant model explaining a high proportion of the variation in group belonging (CON or CWP) was obtained ( Table 3 ).

Additionally, we observed a strong trend toward a transient increase in CSF muHTT protein in Hu97/18 CSF following striatal injection of the neurotoxin quinolinic acid (QA) ( Fig. 4D ).

In this case, p ( t ) also shows an increasing trend that eventually yields the increase in the entire activity over time both in the empirical and simulated data, Fig. 5a,c .

The difference in the resulting library size, and hence in screening cost, may be small or even negligible (as was in our case), but when the WT bias is very high, the savings due to choosing the better method might be significant.

Therefore, we adjusted for nominally significant eigenvector of principal component 1 using logistic regression in order to control the potential population stratification for further analysis on remained 98 cases and 98 controls.

P ≤ 0.05 was considered statistically significant and P ≤ 0.01 was highly significant.

The phase difference between two populations was highly significant ( P Mann-Whitney U test = 1.61 × 10 −12 ).

This would still reduce CSS and CNTBC with more than 30% ( T = 84), with only a marginally non-significant reduction in sensitivity (two additionally missed TB cases).

In particular, samples showed a decreasing trend in the VEGF activity over time, thus confirming an effective VEGF release (see Supplementary Information , Figure S3 ).

An evident trend toward higher OPN expression with the deeper tumor invasion was identified, though there was no statistically significant difference.

CXCL12 attracted the highest number of all three progenitor subsets inducing a highly significant response compared to the migration in absence of any chemokine at all times of fetal liver development tested in our experiments, both CLP and MP as well as for the lympho-myeloid fLMPP cells ( Fig. 5a ).

The TDT results showed a marginally significant association between TS and SNP rs4979356 and rs4979357.

Although transaminase increases were common with trabectedin, they followed a predictable pattern with a peak elevation at days 5–7 and a return to grade ≤1 at approximately day 15 of each cycle, and with a clear trend towards reduction with subsequent cycles ( Fig. 4 ) 10 , 17 .

There was an increasing trend regarding the incident age of ESRD(mean age 55.0 in 1999 and 59.5 in 2010; p value for trend: 0.01) and the percentage of patients choosing PD as the dialysis modality among the patients with PCKD (4.2% in 1999 and 10.4% in 2010, p value for trend: 0.02)during 1999 to 2010.

An Italian case-control study found a marginally significant excess of homozygosity for the rs890 29 .

Interestingly, a high abundance of Alphaproteobacteria was captured at B0, with a decreasing trend along the water column of station B.

rs11200638 ( HTRA1 ) and rs2230199 ( C3 ) approached significance but did not meet the Bonferroni corrected P value threshold.

In the present study, VEGF, a driving angiogenic factor, showed a trend to reduced transcript levels.

Although not statistically significant, PpIX fluorescence in ER-positive MDA-MB-361 cells showed a trend of increased mitochondrial localization compared with MCF10A cells.

As the effect sizes for the majority of these genes were small (<1 SD) and close to significance cutoff, it may explain the limitations in replicating these findings in our smaller sample set.

Promoter regions of 77 genes (44.5%) with highly significant decrease in placental expression in PE contain potential response elements for all three TFs.

A large increase in DMS emissions might also act to offset an increasing trend in the global mean precipitation.

Among the nominally significant loci, there are 16 regions that overlap with gene exons ( Table 3 ) which are very likely to have direct impact on the gene products.

Our protein-protein interaction network search detected its predicted interactions with a group of kinesin family members and microtubule associated proteins, which resulted in the highly significant enrichment of GO biological processes of “microtubule-based movement” and “microtubule-based process.” The mouse homolog of AKNAD1 has not been well characterized, but similar functional interaction network searches also yield a group of predicted functional partners enriched in endoplasmic reticulum related processes.

To identify independent relationships and adjust the effects of covariates, multiple linear regression analyses were performed including all parameters with highly significant correlations in the univariate analysis as covariates.