All fitted models were highly significant ( F 5,122 = 26.1, p -value < 2.2 × 10 -16 with ‖ Δ ^ ̄ − Δ ‖ as response; F 5,122 = 47.7, p -value < 2.2 × 10 -16 with λ ^ ̄ as response; and F 5,122 = 12.1, p -value = 1.6 × 10 -9 with | ε ^ g e n − ε ̃ g e n | ̄ as response); residual plots showed no large deviations from the assumptions of normality of error distribution (an asymptotic normal distribution of the response variables is warranted by the central limit theorem), homoscedasticity, and independent errors (data not shown).
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The Spearman’s correlation coefficients (ρ) between the positions of the markers on linkage map and physical map were positive (0.996-to-0.999) and highly significant (p-value < 2.2e -16 ), with an average of 0.999 ( Supplementary Table 5 ).
In addition, 82.5% of DMR-associated transposons are annotated as containing a transposable element gene, a highly significant enrichment compared with all annotated transposons (Fisher’s exact test, P <2.2e−16).
Cross‐correlation analysis revealed a highly significant relationship between the number of D calls from the manual validation and automatic classifier (Pearson's correlation coefficient = .991, p < 2.2 × 10 −16 ; Figure A1 ).
0.00276, Fisher's exact test p-value = 1.34e-05), there is a highly significant excess of sites supporting the species topology (0.00229 vs. 0.00210, Fisher's exact test p-value < 2.2e-16) and deficit of sites in these regions supporting ILS topologies (0.00042 vs. 0.00066, Fisher's exact test p-value < 2.2e-16, Fig 2B and 2C ), which suggests that the observed reduction of ILS is not the result of a lower mutation rate.
Clustering of MBM regarding β-values of each CpG area revealed a highly significant ( p < 2.2e−16) separation of BRAF mut and BRAF wt /NRAS mut tumors (Fig. 8a , right panel).
One notes highly significant terms for time (β-est. = 0.21, (95%C.I. 0.17, 0.25), p < 2.2 × 10 −16 ), monthly cannabis use (β-est. = 2.97, (1.91, 4.03), p = 8.2 × 10 −8 ), cannabis use quintiles (β-est. = 3.86, (2.45, 5.27), p = 1.2 × 10 −7 ), dichotomized cannabis use quintiles (β-est. = 3.54, (2.19, 4.89), p = 4.4 × 10 −7 ) and time: quintile interactions. 3.4.
Based on paired t -test, we showed that the exponential regression model had highly significant mean R 2 accuracy than each of the existing methods (Holsteins: t = 584.8–37281; p < 2.2–16; Jerseys: 1178.5–5861.4; p < 2.2e-16).
Indeed, this overestimation was highly significant (1-tailed t- test, t = 9.66, df = 557.16, p < 2.2 –16 ).
However, it is interesting to note the highly significant co-directionality (binomial test: p < 2.2e−16) of the expression changes observed for nitrogen-limited cultures and in hospite symbionts, with 92.67% of the 12,295 (11,394) DEGs changing expression in the same direction (Fig. 2 e).
This correlation is also highly significant when averaging polymorphism and divergence within 10-bp adjacent windows ( ρ = 0.50; P < 2.2 × 10 −16 ; fig. 1 ).
We find a highly significant correlation (ρ = 0.15, P < 2.2 × 10 −16 ) ( Supplemental Fig.
The enrichment for tryptophan-depletion-induced W>F peptides (44 versus 4) is highly significant, considering the globally reduced protein expression ( P < 2.2 × 10 −16 ; Fig. 2b, d ).
Samples tended to cluster according to batch of origin, indicating systematic rather than random variation with highly significant differences in LCR-associated z-scores across batches (Kruskal–Wallis p < 2.2 × 10 −16 ) and multiple significant pairwise contrasts identified by Wilcoxon tests.
Results There was large variation in cross-correlations among MD scores, from nil (t=0.0, p=0.54) to highly significant (t=0.97, p<2.2e-16).
The traits are much more correlated in both twin groups than in twin-spouse pairs or unrelated individuals (all comparisons were highly significant, p < 2.2e16).
Food Deserts: In stark contrast, the food desert index showed a strong and highly significant positive spatial autocorrelation (I = 0.4563, p < 2.2 × 10 −16 ).
Moreover, not only do we find differences in predictive performance between populations from different continents, we also find highly significant differences in prediction accuracy among the four European ancestry populations considered ( F -test p -value < 2.2 × 10 −16 ).
Strikingly, PFC Aliceblue and NAc Cadetblue 2 showed a highly significant overlap in their gene content, with 72 overlapping genes ( S2 Table ; p = 2.2 x 10 −16 ).
In addition, the correlation between gene expression and TF binding was highly significant ( P = 2.2× 10 −16 , see Additional file 1 Supplementary Methods) and the likelihood of a TF complex near transcriptionally active genes showed that the TF complexes are most likely located -1kbp to 0.5kbp around TSS (Fig.
andersonii (tested via independent samples Wilcoxon rank-sum test), while its F is value was also significantly lower ( P < 0.05).Furthermore, verification of Rarefied Allelic Richness (Ar) via the Kruskal-Wallis rank sum test revealed a highly significant difference between the two species (chi-squared = 1770.3, df = 1, P < 2.2e-16), confirming that the genetic diversity of B. andersonii is robustly higher than that of B. tianguii even after standardizing sample sizes ( Figure 3 ). 3.3.
Note that likelihood ratio tests comparing the model results without and with the T1WP correction were all highly significant ( p < 2.2 × 10 − 16 ), probably due to the high number of observations and relatively small number of terms in the model.
All reported correlations were highly significant ( p < 2.2 × 10 −16 ).
However, these correlations were still highly significant ( P values < 2.2e-16 in both Pearson and Spearman correlation tests).
Indeed, we observed a moderate, though highly significant correlation between CDS length and fold change (FC) in translation (r 2 = 0.26; p < 2.2 × 10 −16 ), which produces a downregulatory effect for genes with long CDSs and, vice versa, an upregulatory effect for genes with short CDSs (Fig. 2 C).