Excerpts

Comparison between the ratings of the general public and veterinarian responses was highly significant (LR = 330.31; df = 6; p < 2.2e -16 ) with veterinarians rating dog breeds as less sensitive overall than the ratings from the general public.

Highly significant p -values for both directions (lesser and greater, p < 2.2 × 10 −16 ) were recorded.

The final model was highly significant ( p = 2.2e−16), and for all three cancer types IRF1 was identified as a significant explanatory variable for CD274 expression (Table 1 , left 3 columns).

Additionally, the P-value for accuracy being greater than the No Information Rate (NIR) was highly significant (P < 2.2e-16), indicating that the model’s performance was far superior to random chance.

Remarkably, we observed a highly significant negative correlation between B cell levels and HEUScore among all immune cell subtypes ( r = -0.8857, P < 2.2e-16) ( Figure 5G ).

The Kruskal–Wallis test revealed highly significant differences between conditions at 0–24 h (H = 147.38, df = 2, p = 2.2 × 10 −16 ) and 24–48 h (H = 121.46, df = 2, p = 2.2 × 10 −16 ).

2 A), which was still highly significant ( p = 2.2e-16) due to the number of data points.

However, of those that overlapped, there was a highly significant enrichment for effect direction concordance (i.e., increased binding with increased accessibility; OR = 18.0, P -value < 2.2 × 10 −16 ), suggesting replication across these distinct studies.

The difference in the comparison of In100-element flanking exons and the control exon pairs is highly significant (Fisher's Exact Test, P<2.2×10 −16 , df = 1; Figure 4 ).

This finding of 50% sensitivity (considering only the peaks that strictly overlap a site) is highly significant (Fisher’s exact test; P < 2.2 e –16) and is a strong indication of the quality of the results, all the more so as the literature derived studies were performed in a variety of species and cell types.

Based on paired t -test, we showed that the exponential regression model had highly significant mean R 2 accuracy than each of the existing methods (Holsteins: t = 584.8–37281; p < 2.2–16; Jerseys: 1178.5–5861.4; p < 2.2e-16).

As a result, we found a highly significant positive relationship between visual bleaching scores on Day 0 and Day 7 post-stress ( Fig 3A and S2 Table , linear mixed effects model, p < 2.2e -16 , marginal R 2 = 0.863, df = 44), such that VBS at Day 0 post-stress was highly predictive of VBS throughout the following seven-day period.

Furthermore, a linear model comparing the paired connectivity estimates from the 24-particle and 1-particle-per-day scenarios revealed a highly significant (p < 2.2e-16) and remarkably strong linear relationship, closely approaching a 1:1 correspondence (R-squared = 0.999; Fig. 3 ).

Results show that the correlation between PADI2 and HER2/ERBB2 overexpression is highly significant across the luminal, basal-NM (non-malignant), and claudin-low cell lines (rho = 0.828, p = 2.2 × 10 -16 ) (Figure 3 ).

All correlations were highly significant (for all: P < 2.2 E-16; more details on performance estimates and model statistics, see Text S1 in the Supplementary Material).

We further validated the relationship between UMOD and NKCC2, by Taqman qRT-PCR, showing a highly significant correlation of expression (p = 2.2e−16, R = 0.844) (n = 86).

We find a highly significant departure from the expectation that the mean blunting score is equal to zero (two-tailed one-sample t test P < 2.2 × 10 −16 ), demonstrating that deletion of ENH5 results in a transcriptome-wide dampening of the response to sustained hypoxia ( Fig. 3E ).

Pearson's Chi-squared test showed that this difference is highly significant ( P < 2.2e − 16).

Furthermore, a highly significant correlation was observed between the level of dysregulation of these 1,520 common DEGs within the two datasets (Pearson correlation test, R = 0.73, P -value < 2.2 × 10 −16 ) ( Fig 3B ).

The latter explanation is supported, because there is a highly significant between-haplotype component of variation for the trait ( P < 2.2 × 10 −16 for the whole data set; P between 4.1 × 10 −13 [L14] and 0.022 [L06] for the individual MA lines).

Analysis of variance based on the reparametrized polynomial-interaction model with MPR effects showed a highly significant impact of partial yields on test-day yields ( P <2.2e-16).

In addition, CREB1 is the top upstream regulator of the 465 overlapping differentially expressed genes (see previous texts) and there is a highly significant, negative correlation ( r = − 0.91, p value = 2.2E−16) between the fold changes for these genes—including the 58 direct CREB1 target genes—in the two comparisons (Supplementary Fig. 3 ).

The enrichment for tryptophan-depletion-induced W>F peptides (44 versus 4) is highly significant, considering the globally reduced protein expression ( P < 2.2 × 10 −16 ; Fig. 2b, d ).

While the p -values are highly significant ( p -value < 2.2e–16), this is likely due to the large sample size, and the relationship between TE content and gene expression is rather weak (Fig. 3 G), suggesting that genes can be highly expressed despite containing substantial intronic TE densities.

Food Deserts: In stark contrast, the food desert index showed a strong and highly significant positive spatial autocorrelation (I = 0.4563, p < 2.2 × 10 −16 ).