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highlights probes on HIP1 , LMAN2 , and MOBP genes, however, in our setup the most significant probes on HIP1 and LMAN2 genes were only nominally significant (cg08710628 on HIP1 , P = 0.003; cg05408837 on LMAN2 , P = 0.008), whereas no probes on MOBP were significant.

When examining the genetic overlap between thyroid hormones and sex hormones, we observed suggestive, nominally significant positive genetic correlations between testosterone and both FT3 ( p = 3.00 × 10 −3 ) and FT4 ( p = 7.90 × 10 −3 ), as well as a Bonferroni-significant positive genetic correlation between FT4 and SHBG ( p = 2.00 × 10 −4 ); we additionally observed a suggestive negative genetic correlation between testosterone and TSH ( p = 4.50 × 10 −3 ). 3.3.

CAEP Waveforms Figures 5A–C show exemplar sets of waveforms for three participants for whom both signals were audible at the initial test level (15 to 20 dB SL) and for whom all responses were highly significant ( p < 0.003) according to HT 2 .

Using the mentioned macronutrients and questionnaire derived intake variables as covariates in the analysis of disease‐associated shifts in microbial beta‐diversity yielded no significant associations ( P > 0.05, respectively) and also revealed only minor effects on the still highly significant change in community composition associated with PSC ( P = 0.003, R 2 = 0.019). 4 DISCUSSION It is unclear, to which extent reported single centre microbiota studies in PSC were influenced by environmental factors and whether reported associations would remain significant across different geographical regions.

We found that the density effect was highly significant and had a positive correlation with development time (estimate = 0.051, P = 0.003).

Overall, this finding suggests that more information about Notochthamalus will be recovered from further exploration in locations to the south of Niebla; additional genotyping also will be necessary to increase the power of this test, as the five loci indicated have only marginally significant results for the CND test; correction for multiple testing would, in fact, require a P -value of <0.003, which none of these loci obtain.

A highly significant association was observed between MV miR-21 levels and the anatomic location of the tumor ( P = 0.003), whereas the association with PV miR-21 levels was less significant ( P = 0.01) (Table 1 , Figure 1 C). miR-21 Expression and Metastases Of the 13 patients who developed metastases during the course of the disease, 8 had metastases in areas drained by the MV of the colon: 4 peritoneal metastases, 2 liver metastases, and 2 anastomotic.

On comparison between Group I and II using paired t -test, statistically significant difference was observed in all the parameters with highly significant reduction in GI ( P < 0.003) at 3 rd week.

A significant reduction in CHD incidence (HR: 0.70; 95% CI: 0.56, 0.87) occurred among baseline normotensive participants where evidence of postrandomization confounding by statin use was absent, whereas there was no evidence for an intervention effect among baseline hypertensive participants, with a highly significant contrast between the 2 ( P = 0.003).

A higher three-year OS rate was found in the HS group, which was highly significant (RR 0.70, 95% CI 0.55-0.89, P = 0.003; Figure 2(b) ).

In CAD, the incidence of triple vessel disease was marked in diabetic patients with a strongly significant difference from non-diabetic patients (p<0.001, D=54.5%, N-D=29.7%) while for single vessel disease, the incidence was greater in non-diabetic patients with a slightly significant difference from the diabetic group (p=0.003, D=18.8%, N-D=33.9%).

The mRNA expression levels of ChREBP and PPARα were highly significant in the interaction effects of exposure time and salinity ( F = 4.178, p = 0.003; F = 10.955, p = 0.000).

This is a highly significant change ( p = 0.003, paired two-tailed t -test), and the difference from baseline after switch-on is also highly significant ( p = 0.008, paired two-tailed t -test).

Of the multicenter cohort consisted of 888 adults with community-onset bacteremia initially complicated with severe sepsis and septic shock in the emergency department (ED), a positive linear-by-linear association ( γ = 0.839, p < 0.001) of the time-to-appropriate antibiotic (TtAa) and the hypotension period after appropriate antimicrobial therapy (AAT) was exhibited, and a positive trend of the hypotension period after AAT administration in the 15-day ( γ = 0.957, p = 0.003) or 30-day crude ( γ = 0.975, p = 0.001) mortality rate was evidenced.

Further Kaplan–Meier analysis stratified by tumour stage revealed a highly significant difference in survival based on tumour size (log-rank p = 0.003), with patients having tumours > 4 cm experiencing markedly poorer survival, particularly in Stage III–IV disease, where their median survival was only 26 months, compared to those with tumours ≤ 4 cm, whose median survival was not reached.

Acute ENU exposure resulted in a dose‐dependent increase in MF that was highly significant starting at the lowest dose tested ( P = 0.003 at 25 mg/kg).

Correlation between Nitric Oxide and Inflammatory Serum/blood Parameters Our data reveal a highly significant negative correlation (Spearman’s correlation coefficient rho = −0.41, p = 0.003) between nasal NO and leucocytes in blood.

Compared with lisinopril monotherapy, dual blockade treatment caused a highly significant reduction in 24-hour PP levels (−5 ± 5 mmHg, P = 0.003), albeit the difference in the BP lowering effect between the treatment groups did not differ significantly for 24-hour SBP ( P = 0.21) or DBP ( P = 0.49).

This was confirmed with a one-way ANCOVA comparing standard scores of verbal ability between children who do and do not report playing a musical instrument, with age, sex, SES, and VO 2 max as covariates: the effect of playing an instrument was highly significant [ F (1, 94) = 9.10, p = 0.003, partial η 2 = 0.091].

Correlation analyses As can be seen in Figure 4A , there was a highly significant positive linear relationship between the attention effect in left SI and left SII, r = .64, p = .003.

In primary rat liver hepatocytes, MPEP dose-dependently reduced ATP concentration, producing a near-significant effect at 3 μM and a markedly significant effect at 30 μM ( p = 0.003).

Additionally, we further measured the rise in N2pc amplitude and the rise in CDA amplitude from one item to two items and found that there was also a highly significant correlation between the rise in the N2pc amplitude and the rise in CDA amplitude for both adults with ADHD (r = 0. 532, p = 0. 003, two-tailed) and controls (r = 0. 487, p = 0. 006, two-tailed).

Multivariate analysis revealed the impact of a location within the central lobe on seizure risk to be highly significant and more relevant than histopathology (OR: 4.79, 95% CI: 1.82–14.52, p = .003).

The number of infants in Group 2 was statistically highly significant ( P = 0.003).

HOX B13 showed a trend of statistical association with sex and age, and a strong direct statistical association with lymph nodes metastasis (p value = 0.003).