Excerpts

We confirmed a decreasing trend in both decades, with a yearly average decrease of 6.4% (IRR=0.939, 95% CI 0.899–0.980; p=0.004) in the first decade, and of 6.2% (IRR=0.920, 95% CI 0.849–0.997; p=0.043) in the second decade.

These transformations were further justified, since there was an extremely highly significant difference found between the variances of these groups (F-test), i.e., that for first-year students was much greater than that for the final-year cohort ( p = 0.004).

Further, two-way ANOVA analysis of the HFD-fed groups indicated a significant or nearly significant effect of BC lowering fasting blood glucose ( p = 0.004), insulin ( p = 0.047) and HOMA-IR ( p = 0.053), and no significant effect of MET on these parameters ( p = 0.106, p = 0.610 and p = 0.351, respectively).

The interaction was previously significant or marginally non-significant in models 3 ( P = 0.004), 5t ( P = 0.07), and 5i ( P = 0.06).

At F2 generation, a highly significant negative correlation was detected between the T-ratio of ZW males and their mating frequency with Z30 females ( r =-0.71; P = 0.004; Fig.

Distribution of verbal abuse with respect to age of HCWs is statistically highly significant (p value=0.004).

When comparing mean fluorescence intensities, a three-way ANOVA for repeated measures with cell type and cytokine as within-subjects factors and infection status as between-subjects factor revealed a highly significant three-way interaction of cell type, cytokine, and infection status ( F 1, 8 = 15.54, p = 0.004), reflecting an increased expression of IFN-γ in CD4 + lymphocytes (post hoc two-sample t test: t 4.3 = 2.31, p = 0.036, one-tailed), while no further significant differences were observed (all t < 0.916, all p > 0.197, one-tailed).

We did observe inverse correlations within the female and male groups between testosterone and IgG3 levels, and oestradiol and IgG3 levels, but these correlations did not reach statistical significance after Bonferroni multiplicity correction (threshold p < 0.004) (Supplementary Fig. 8a–g ).

The IL-12 p40 subunit forms part of the heterodimer IL-23 [ 34 ], so the highly significant correlation between IL-12 and IL-23 (r = 0.880, p = 0.004; Table 3 ) noted in the tissue of subclinically affected cows was unsurprising ( Table 3 ).

Persistent cough after 2-week ICS treatment showed a significant trend to increase as past duration of cough, reported as baseline, increased (linear trend analysis, p = 0.004) ( Fig. 2 ).

Over the period of observation, there was a significant trend of falling breast-cancer-related mortality in the 50+ age group ( p = 0.004), as well as overall ( p < 0.001).

When other adipokines/hepatokines were assessed together, the significant association between ANGPTL8 with LVMI remained highly significant ( P =0.004).

An evaluation of mean speed based on vehicle CAN data indicated a significant overall difference in speed between the two vehicles (Volvo M = 107.5 km/h; Chevrolet M = 111.6 km/h; F (1,78) = 5.4, p < 0.023); this difference was apparent even during baseline just driving periods (109.4 and 113.1 km/h, respectively; F (1,78) = 8.9, p = 0.004).

In the case of ileum, Rothia, Atopobium, Staphylococcus , and Peproniphilus represented a highly significant (P=0.004, P=0.003, P=0.006, P=0.009, respectively) negative correlation, and Actinomyces and Eubacterium represented a significant ( P = 0.015 and P = 0.014 respectively) negative correlation with VH ( Figure 5 C).

However, there was a significant trend toward an increased incidence of AOM with a tympanic bulge by Veau classification ( p = .004).

For all three conditions, the decline in looking time across the four encoding trials was clearly significant (Storyline Condition: F [3, 102] = 4.66, p = 0.004, partial Eta-Squared = 0.121; Pixelized Condition: F [3, 72] = 19.04, p < 0.001, partial Eta-Squared = 0.442; Scrambled Condition: F [3, 102] = 25.74, p < 0.001, partial Eta-Squared = 0.431).

There was a highly significant interaction between the effects of seizure and cortex for occurrence [ F (1,42) = 9.071, p = 0.004] and Up states index of spontaneous activity [ F (1,42) = 12.7, p = 0.001]; and a marginally significant effect of the two on Up state amplitude [ F (1,42) = 4.172, p = 0.047] and rectified area [ F (1,42) = 4.151, p = 0.048] ( Supplementary Text , Section 2.1.2 , Table 9 ).

Notably, after controlling for interaction between PDL1 and HLA-I in the model, HLA-I homozygosity emerged as having a highly significant association with OS (HR=3.70, 95% CI 1.53 to 8.95, p=0.004).

The change in performance for the Jump Down Test was marginally significant in discordance with changes in the sensorimotor variable cEQ Score measuring balance control ( P = 0.004).

The difference was apparent at 24 h (hyperthermia; mean 2.9±3.6 vs control; mean 26.2±3.5 p=0.004) and at 48 h (hyperthermia; mean 4.4±5.1 vs control; mean 43.4±8.9 p=0.001) after hyperthermia ( Fig. 5 ).

Surprisingly, mice that received only a twice-greater dose (10 μCi) demonstrated greatly decreased tumor growth inhibition, and the tumor volume difference between mice receiving the 5 μCi versus the 10 μCi dose became extremely significant over the ensuing two weeks ( P <0.004).

In contrast, the ratio of SM resistant in non-Beijing genotype (32.4%) was higher than that of Beijing (27.9%), the difference of which was highly significant (χ 2 = 8.26, P = 0.004).

Sodium showed an increasing trend in group 1 at T2 (p = 0.004), T3 (p = 0.002), and T4 (p = 0.011), which was statistically significant.

Similarly, nationality had a highly significant association with HCV infection (p=0.004).

This significant difference was apparent in the intermediate ( P = 0.004) and high-risk group ( P < 0.001) but not in the low ( P = 0.62) and in the very high-risk group ( P = 0.10; Table 4 ).