Excerpts

Unvaccinated patients had a significant trend toward higher rates of obesity (41% vs 29%; p = 0.004).

When combining the highly specific criteria size (cut-off value 10 mm), inhomogeneous signal intensity, and number of visible lymph nodes n ≥ 7, a highly significant association with nodal metastases (pN+, p = 0.004) was found.

A significant trend for associations with WHZ were only observed for the maize and fish-based DPS in the multiple-adjusted model (0.03, 95% CI: 0.01, 0.06, p = 0.004).

We also observed a highly significant increase in the frequency of NK cells labeled with 2F1 antibody ( P = 0.004), which recognizes the maturation marker KLRG1, in BALB- Cmv3 MA/My H2 d mice compared to their H2 k counterparts.

During the period from 2014 to 2021, the number of hospitalized cases of CD had an increasing trend year by year ( r = 0.876, p = 0.004); meanwhile, there was no significant change in the number of UC inpatients ( r = −0.119, p = 0.780) ( Figure 1 ).

There was an increasing trend for the Lawani index of authors, AAGR = 9.4%, p = .004, as of affiliations, AAGR = 11.2%, p = .002 and of countries, AAGR = 6.8%, p = .002.

The Mantel test indicated a highly significant correlation between environmental variables (exchangeable K + and exchangeable Mg 2+ , and urease activity) and ECM fungal community ( r = .33, p = .004; r = .40, p = .003; r = 0.25, p = .017, respectively). 4.

Findings from the multivariate test of Wilks’s Lambda showed a highly significant age main effect [Wilks’ Λ = 0.942, F (4, 506) = 3.869, p = 0.004] on students’ academic burnout.

The results of the presented study obtained on skeletal muscle showed an increasing trend of Caspase 9 immunoreactivity from 4 up to 8 h after death ( p = 0.004), followed by stable—though slightly decreased—levels up to 24 h; a significant immunoreactivity decrease was observed 72 h after death.

At the same time, we found a highly significant sex × area × species interaction (F 1,164 , P = 0.004), suggesting that sexual dimorphism depends on the island size, but with species-specific patterns.

Average eccentricity showed a trend toward a higher value with increasing age (r 2 = 0.48, p = 0.004), and was higher in the older group, signifying that cells had a more elongated shape as they aged ( Table 9 , p = 0.01; Figure 8D ).

We confirmed a decreasing trend in both decades, with a yearly average decrease of 6.4% (IRR=0.939, 95% CI 0.899–0.980; p=0.004) in the first decade, and of 6.2% (IRR=0.920, 95% CI 0.849–0.997; p=0.043) in the second decade.

The prevalence of Pseudomonas aeruginosa showed a decreasing trend ( p = 0.004), whereas coagulase-negative Staphylococcus (CNS) and Propionibacterium species were increasingly detected ( p < 0.001).

Regarding experience with COVID-19, those who had no personal experience made a greater recourse to the avoidance strategy, t (882) = 3.95, p < 0.001, d = 0.30, with a nearly significant effect on the transcendent orientation strategy, t (882) = 2.87, p = 0.004, d = 0.22.

These transformations were further justified, since there was an extremely highly significant difference found between the variances of these groups (F-test), i.e., that for first-year students was much greater than that for the final-year cohort ( p = 0.004).

In addition, the children of the MIPAS-Family group reported highly significant reductions of the headache frequencies (Pre–Post 1: z = −2.841, p = .004; Pre–Post 2: z = −3.126, p = .002), whereas the children of the Biofeedback group only showed a significant improvement for the Pre–Post 1 comparison ( z = −2.333, p = .02).

The ANCOVA model for selection comparison between two morphs was also highly significant, explaining about 87.8% of total variation (F = 2.88, p = 0.004).

0.056 ± 0.039 mm, P = 0.10), although here, interocular differences in AL did not reach statistical significance until day 5 of CL wear (0.306 ± 0.081 vs. 0.172 ± 0.057 mm, P = 0.004, Fig. 1 B).

Distribution of verbal abuse with respect to age of HCWs is statistically highly significant (p value=0.004).

We did observe inverse correlations within the female and male groups between testosterone and IgG3 levels, and oestradiol and IgG3 levels, but these correlations did not reach statistical significance after Bonferroni multiplicity correction (threshold p < 0.004) (Supplementary Fig. 8a–g ).

Factors Associated with DAO Levels When considering the median DAO, a significant trend of increasing DAO was seen with increasing BMI ( p = 0.004) and increasing age ( p <0.001), where the group >61 years were found to have a higher DAO than other age groups ( Figure 2 ).

We tested drug-drug interactions for three pairs: KP372-1 + rucaparib, KP372-1 + olaparib, and KP372-1 + talazoparib, all of which showed highly significant effect of synergy (η = 0.472, P = 0.004; η = 0.453, P = 0.002; η = 0.613, P = 0.009, respectively).

A highly significant ( P = 0.004; 0.006, P < 0.01) difference in temperature was observed between healthy and diseased legs at both measurement points.

Segmented regression showed an increasing trend in impact factor for publications during 1972 to 1996 ( β = 0.16, p = 0.004) and a decreasing trend during 1997 to 2023 ( β = −0.048, p = 0.005).

The effect of food level variation was quite significant ( F 1,33 = 9.68, p < 0.004), while the effect of variation between densities was not ( F 1,33 = 1.59).