Excerpts

Furthermore, a positive trend in risk with increasing years of diagnosis of diabetes ( P =0.004) and of hepatitis ( P =0.02) was observed.

(B) A positive trend with urban land cover ( β = 0.008; p = 0.004).

Compared with the MDRD-GFR and CMDRD-GFR, the NRI of the CKD-EPI-GFR was calculated at 0.10 and 0.09, and was highly significant ( P = 0.004 and P < 0.001).

Phylogenetic generalised least squares regression The phylogenetic generalised least squares (PGLS) analyses on the Bulbophyllum backbone phylogeny revealed a generally strong, either marginally significant ( R 2 = 0.883, P = 0.060) or highly significant ( R 2 = 0.993, P = 0.004) relationship of, respectively, the stem and crown ages of the four lineages with their extant species numbers.

After correction for multiple testing using the SNP Spectral Decomposition Lite program (number of independent marker loci, 21; p = 0.05/21 = 0.002), only the Dectin-2 rs4264222 and Dectin-2 rs7134303 associations in women retained significance ( P = 3.00 E-04 and P = 9.00 E-04), whereas the associations with DC-SIGN rs4804803, MCP-1 rs1024611 and MCP-1 rs4586 showed borderline significance in the whole population ( P = 0.004, P = 0.006 and P = 0.009; Table 3 ).

Using this approach, GEE with ICP as the independent variable weighted for distance of measurement and ONHV or ONHH as the dependent variable were weakly significant for ONHV (B = 0.020, SE = 0.007, p = 0.004) and interestingly significant for ONHH with a negative association (B = −0.003, SE = 0.0005, p<0.001), meaning that IIH patients with a high ICP showed a more depressed ONHH.

The linear relationship ( r = 0.493; P = 0.074) of dietary CP and breast meat yields approached significance across the tabulated data and, interestingly, increasing digestible protein (N) intakes enhanced breast meat yields quadratically ( r = 0.799; P = 0.004).

As illustrated in Figure 4 , no significant correlation was observed between plasma insulin and D-glucose concentration in the 15 control animals ( r = +0.0416; P > 0.1), whilst a highly significant negative correlation between these two variables prevailed in the 17 STZ rats ( r = −0.6892; P < 0.004).

It shows an increasing trend ( p -value = 0.004) between the first and fourth outbreaks, followed by a downward curvilinear trend ( p -value = 0.03) (Supplementary Table 1) during the fifth wave.

However, on day 6 the infectivity of the oseltamivir-treated infected group was 123-fold higher than the control infected group (10 5.4 ffu per ferret), a highly significant difference ( p = 0.004; Fig. 4 d).

The differences between men and women were statistically and practically significant, with academic stress 0.34 SDs higher for cis women ( p = 0.004) and illness stress 0.51 SDs higher ( p < 0.001).

After combining the two transect probabilities by Fisher's method, overall genetic isolation by temporal distance was highly significant ( P = 0.004).

Some of the microbial components of the ileum were shared among C7, C10 and C14, and the PERMANOVA test confirmed highly significant differences between these three groups and C21 ( P = 0.004).

In Mossi ethnic group we noted that the CD3 + Panγδ + proportion remains stable through the season, whereas in Fulani ethnic group the proportion of these cells was double of that measured in Mossi ethnic group at the low transmission season and this difference was highly significant ( p = 0.004) (Figure 5 ) and remained significant during the high transmission season ( p = 0.04).

The decreased spleen weight was also highly significant after body weight adjustment ( P = 0.004).

The log-rank test revealed a highly significant difference in survival among instars ( χ 2 = 34.7, df = 4, P = 0.004), highlighting developmental stage as a key factor influencing mortality risk.

Comparing the combined intervention arms against control (a secondary comparison) gave a highly significant result ( P = 0.004), although it had not crossed the implicit threshold ( P = 0.002) for proven benefit that was set at the beginning of the study.

A highly significant ( p = 0.004) PCT concentration demonstrated it to be a clinically meaningful effect size and a reliable biomarker in discriminating the progression of TBI post 72 h, with an AUC of 0.834 at 72 h and 0.607 at 24 h from the admission time.

An ANOVA on the combined data revealed a highly significant overall effect of early life intervention (F = 9.714, p = 0.004), but no overall sex effect (F = 0.034, p = 0.856).

This corelation was highly significant if patients did not achieve disease remission ( p = 0.004) or minimal disease activity while receiving intensified therapy with biologics ( p = 0.04).

Finally, the REVEAL (Randomized Evaluation of the Effects of Anacetrapib through Lipid modification) study, involving 30,449 patients with ASCVD randomized to receive anacetrapib 100 mg daily or placebo on top of statin therapy, demonstrated a highly significant reduction (rate ratio 0.91; p < 0.004) in the composite primary endpoint of coronary death, MI, or coronary revascularization [ 55 ].

This is a highly significant enrichment (Fisher's exact test p-value <0.004), demonstrating that many of the genes affected by the Usf1 polymorphism might in fact be direct Usf1 targets.

In models adjusted for age, study site, smoking, BMI, weight, waist, and urinary creatinine, the BPA association with total testosterone levels was highly significant (β = 0.046; 95% CI, 0.015–0.076; p = 0.004; Table 3 ).

Only two observers had very good Intraclass Correlation Coefficient (ICC) (0.757), which was highly significant ( P = 0.004).

This association was markedly significant among patients who achieved both CR V and CR H (95% vs 61%, p = 0.004), and it was observed that induction therapy aimed at reducing VEGF levels has the potential to decrease the risk associated with autologous transplantation.