Excerpts

Finally, visualizing DEM medoids in two-dimensional principal component space revealed a clear trend: PP-increased DEMs and PP-decreased DEMs occupied distinct regions, with the two groups differing significantly with respect to both PC axes (P≤4.1×10 −3 ; Figure S10 ).

It did not reach statistical significance due to Bonferroni-adjustment for multiple testing that resulted in a lowered significance level of p < 0.0041 instead of the usual 0.05.

In addition, a highly significant positive correlation (rho = 0.388, p = 0.0041) was discovered between the osteoarthritis score (combining the histological grade of damage with the OA macroscopic stage) and the percentage of C2C staining in the samples.

The Cochrane's Q test for heterogeneity was highly significant ( P value = 0.0041, I 2 heterogeneity index = 73.83), and we, therefore, analyzed the association under a random effects model.

Also, rapid cycling cases compared to non-RC-BP showed a trend (P = 0.0041) and dominant model association (OR = 1.80, P = 0.0098) ( Table 2 ).

The main correlations with stimulation— d’ average score and d’ approach for low BAS and’ d’ average for low BIS—remain significant and is near significance for approach d’ in low BIS participants when Bonferroni correction is applied (p = 0.0041).

Log-rank tests revealed highly significant differences in molecular groups related to OS ( p = 0.0041, Log-rank test) and PFS ( p < 0.0001, Log-rank test).

Indeed, in three out of six vaccinated animals, tumour growth was essentially suppressed ( Figure 2b ), leading to a highly significant ( P =0.0041; Log-rank, Mantel–Cox test) survival benefit ( Figure 2c ).

Further analysis revealed a highly significant negative correlation between P uptake efficiency and rhizosphere available P content ( Figure 8E ; R2 = 0.29, P = 0.0041), indicating that plants with higher P acquisition capacity tended to deplete soil P more effectively.

Nevertheless, looking at the whole period of six years, this association was found highly significant ( p = 4.108*10 −3 ).

In fact, an ICV reduction in MDD patients who reported having made suicidal plans or attempts was nearly significant at the study-wide level ( P =4.12 × 10 −3 ), with a Cohen’s d =−0.284, or a 2.87% smaller ICV compared to the CTL group.

However, we note that part of our results concerning APP did not achieve significance according to our criteria (FDR<0.05): namely, PSI-PM association in the temporal region (P=0.00416) and ES-SNP association in the temporal region (P=0.027).

However, when we analyzed PV expression levels separately for spiny and non-spiny PVIs, we found a highly significant shift in behaviorally induced PV expression in spiny but not in non-spiny PVIs (p = 0.0042 in spiny versus p = 0.33 in non-spiny PVIs; Figure 4 A), suggesting that spiny and non-spiny PVIs differ in their susceptibility to experience-induced changes in gene expression.

There were highly significant differences ( P < 0.0042) in the prevalence of S . agalactiae , S . dysgalactiae , A . pyogenes , staphylococcal β-lactamase gene, Staphylococcus spp., Klebsiella spp., Enterococcus spp. and S . uberis in BTM between the 3 provinces.

None of them shows an "opposite" response pattern, an observation that is highly significant ( p = 0.0042).

For the Cre viruses, the difference was smaller, presumably due a ceiling effect (see discussion ), but still highly significant: at 1 week, the ΔL-Cre virus had labeled 1.40 times as many cells as ΔGL-Cre (single-factor ANOVA, p = 4.20e−3; n = 4 mice each group); and at the 4 week time point, the ΔL-Cre virus had labeled 1.25 times as many cells as ΔGL-Cre (single-factor ANOVA, p = 7.38e−4, n = 4 mice per group; see Data S1 for counts and statistical comparisons).

In the nivolumab/ipilimumab arm, PFS was numerically higher in the PD-L1≥1% group (median 15.1 months vs NR, p=0.0518) though not quite statistically significant, and the OS also favored the PD-L1≥1% group (median 26.1 months vs NR, p=0.0042).

Highly significant differences (p = 0.0042) between the studied groups were found in the methylation level of the FKBP5_38 __35558438 CpG site ( Fig. 3 ).

The CERS2 variant rs267738 previously associated with RRD ( 16 ) shows nominally significant association, P -value = 4.2 10 −3 , with the major T allele increasing risk as previously reported.

Results: The study found that in the blood of healthy women there is a physiological low-level mosaicism with a clear trend in increased proportion of abnormal cells associated with the increasing age to 1.83%, 2.23% and 5.88% for groups 1, 2 and 3, respectively (P= 0.0042).

Participants employed part time did not reach statistical significance in their differences with unemployed participants ( g = 0.23, p = 0.0042) and those working full-time ( g = 0.25, p = 0.0043).

An increasing trend in defensin transcription was observed in the Caucasian, Carniolan, Syrian, and Yığılca subspecies six days after V. ceranae inoculation ( t -test, p -values = 0.0042, 0.0053, 0.0048, and 0.0102, respectively).

Notably, expression analysis showed a trend of significant upregulation of PACS1 in BD cases compared with controls [ 68 ] ( P = 4.21 × 10 −3 , FDR = 0.072) (Table 2 ).

Three extracts displayed moderately strong negative association with clinical resistance, with halo size decreasing with increasing clinical resistance, of which two were highly significant ( C. rupestris : r = −0.487, p = 0.00423; C. rubrum : r = −0.463, p = 0.00681) and one borderline nonsignificant ( U. lactuca : r = −0.306, p = 0.0567).

This potential effect was highly significant in both validation cohorts (JAAMSR, P = 0.0043, adjusted hazard ratio 0.51, 95% CI 0.32–0.81; SPH, P = 0.018, adjusted hazard ratio 0.76, 95% CI 0.61–0.95) (Additional file 4 : Figure S3b-c).